Publications by authors named "Senthil Radhakrishnan"

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Anthracyclines attenuate Nrf1-dependent proteolytic pathways and potentiate proteasome inhibitor cytotoxicity.
Janakiram R Vangala, Madison A Ward, Bader Albalawi, Ahmed M Elshazly, Nayyerehalsadat Hosseini, Senthil K Radhakrishnan

Mol Biol Cell· December 2025

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Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma.
Konstantinos V Floros, Carter K Fairchild, Jinxiu Li, Kun Zhang, Jane L Roberts, Senthil K Radhakrishnan

Nat Commun· November 2025

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Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation.
Ahmed M Elshazly, Nayyerehalsadat Hosseini, Shanwei Shen, Victoria Neely, Hisashi Harada, Senthil K Radhakrishnan

bioRxiv· February 2025

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Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.
Kranthi Kumar Chougoni, Victoria Neely, Boxiao Ding, Eziafa Oduah, Vianna T Lam, Senthil K Radhakrishnan

Cancer Res Commun· October 2024

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Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.
Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Senthil K Radhakrishnan

J Cell Biol· June 2024

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Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma.
Konstantinos V Floros, Carter K Fairchild, Jinxiu Li, Kun Zhang, Jane L Roberts, Senthil K Radhakrishnan

Res Sq· June 2024

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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Jerry Li, Nicholas Purser, Joanna Liwocha, Daniel C Scott, Holly A Byers, Senthil K Radhakrishnan

Mol Cell· April 2024

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Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma.
Konstantinos V Floros, Carter K Fairchild, Jinxiu Li, Kun Zhang, Jane L Roberts, Senthil K Radhakrishnan

bioRxiv· April 2024

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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway.
Shanwei Shen, Senthil K Radhakrishnan, J Chuck Harrell, Madhavi Puchalapalli, Jennifer Koblinski

Endocrinology· April 2024

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Utility of Routine Preoperative Urinalysis in the Prevention of Surgical Site Infections.
Aden P Haskell-Mendoza, Senthil Radhakrishnan, Ana Lisa Nardin, Kristina Eilbacher, Lexie Zidanyue Yang

World Neurosurg· December 2023

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Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.
Holly A Byers, Amy N Brooks, Janakiram R Vangala, Jacqueline M Grible, Alex Feygin, Senthil K Radhakrishnan

Sci Rep· September 2023

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Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level.
Hatem Elif Kamber Kaya, Senthil K Radhakrishnan

Trends Genet· February 2021

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Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration.
Amy Northrop, Holly A Byers, Senthil K Radhakrishnan

Mol Biol Cell· September 2020

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Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress.
Haruhiko Fujihira, Yuki Masahara-Negishi, Yoshihiro Akimoto, Hiroto Hirayama, Hyeon-Cheol Lee, Senthil K Radhakrishnan

Biochim Biophys Acta Mol Basis Dis· March 2020

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BET Inhibitors Synergize with Carfilzomib to Induce Cell Death in Cancer Cells via Impairing Nrf1 Transcriptional Activity and Exacerbating the Unfolded Protein Response.
Janakiram R Vangala, Ajay Potluri, Senthil K Radhakrishnan

Biomolecules· March 2020

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Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity.
Amy Northrop, Janakiram R Vangala, Alex Feygin, Senthil K Radhakrishnan

Int J Mol Sci· January 2020

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Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.
Janakiram R Vangala, Senthil K Radhakrishnan

J Biol Chem· February 2019

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Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.
Frederick M Tomlin, Ulla I M Gerling-Driessen, Yi-Chang Liu, Ryan A Flynn, Janakiram R Vangala, Senthil K Radhakrishnan

ACS Cent Sci· November 2017

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Nrf1 can be processed and activated in a proteasome-independent manner.
Janakiram R Vangala, Franziska Sotzny, Elke Krüger, Raymond J Deshaies, Senthil K Radhakrishnan

Curr Biol· September 2016

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p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.
Senthil K Radhakrishnan, Willem den Besten, Raymond J Deshaies

Elife· November 2015

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Fourth ventricular schwannoma: identical clinicopathologic features as schwann cell-derived schwannoma with unique etiopathologic origins.
Tiffany R Hodges, Isaac O Karikari, Shahid M Nimjee, June Tibaleka, Thomas J Cummings, Senthil Radhakrishnan

Case Rep Med· August 2012

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Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.
Senthil K Radhakrishnan, Candy S Lee, Patrick Young, Anne Beskow, Jefferson Y Chan

Mol Cell· April 2010

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FOXM1: the Achilles' heel of cancer?
Senthil K Radhakrishnan, Andrei L Gartel

Nat Rev Cancer· March 2008

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Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.
Senthil K Radhakrishnan, Uppoor G Bhat, Douglas E Hughes, I-Ching Wang, Robert H Costa

Cancer Res· October 2006

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Pro-apoptotic role of NF-kappaB: implications for cancer therapy.
Senthil K Radhakrishnan, Sitharthan Kamalakaran

Biochim Biophys Acta· August 2006

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