Publications by authors named "Seth Thacker"

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2024 White Paper on Recent Issues in Bioanalysis: Evolution of Immunogenicity Assessment beyond ADA/NAb; Regulated Genomic/NGS Assays; Hypersensitivity Reactions; Minimum Noise Reduction; False Positive Range; Modernized Vaccine Approaches; NAb/TAb Correlation - Recommendations on Advanced Strategies for Molecular Assays and Immunogenicity of Gene Therapy, Cell Therapy, Vaccine; Biotherapeutics Immunogenicity Assessment & Clinical Relevance - Regulatory Agencies' Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell & Vaccine Therapies).
Omar Tounekti, Sandra Prior, Sarah Wassmer, Joshua Xu, Adrian Wong, Seth Thacker

Bioanalysis· February 2025

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Cell-Based Assays to Detect Innate Immune Response Modulating Impurities: Application to Biosimilar Insulin.
Cheng Her, Seth Thacker, Joseph Balsamo, Logan Kelley Baker, Derek Dc Ireland

AAPS J· December 2024

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2023 White Paper on Recent Issues in Bioanalysis: ISR for ADA Assays, the Rise of dPCR vs qPCR, International Reference Standards for Vaccine Assays, Anti-AAV TAb Post-Dose Assessment, NanoString Validation, ELISpot as Gold Standard - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Biotherapeutics Immunogenicity & Risk Assessment; ADA/NAb Assay/Reporting Harmonization).
Johanna Mora, Rachel Palmer, Leslie Wagner, Bonnie Wu, Michael Partridge, Seth Thacker

Bioanalysis· April 2024

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2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs ( - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Matt Szapacs, Wenying Jian, Daniel Spellman, Jennifer Cunliffe, Elizabeth Verburg, Seth Thacker

Bioanalysis· August 2023

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2022 White Paper on Recent Issues in Bioanalysis: FDA Draft Guidance on Immunogenicity Information in Prescription Drug Labeling, LNP & Viral Vectors Therapeutics/Vaccines Immunogenicity, Prolongation Effect, ADA Affinity, Risk-based Approaches, NGS, qPCR, ddPCR Assays ( - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Immunogenicity & Risk Assessment of Biotherapeutics and Novel Modalities; NAb Assays Integrated Approach).
Luying Pan, Johanna Mora, Karl Walravens, Leslie Wagner, Shirley Hopper, Seth Thacker

Bioanalysis· July 2023

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Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients.
Seth G Thacker, Cheng Her, Logan Kelley-Baker, Derek D C Ireland, Mohanraj Manangeeswaran

Front Immunol· September 2022

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BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein.
Mohanraj Manangeeswaran, Derek D C Ireland, Seth G Thacker, Ha-Na Lee, Logan Kelley-Baker

Front Immunol· August 2022

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Characterization of the therapeutic effect of antibodies targeting the Ebola glycoprotein using a novel BSL2-compliant rVSVΔG-EBOV-GP infection model.
Ha-Na Lee, Ian L McWilliams, Aaron P Lewkowicz, Kaliroi Engel, Derek D C Ireland, Seth Thacker

Emerg Microbes Infect· December 2021

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Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations.
Melissa A Pegues, Karol Szczepanek, Faruk Sheikh, Seth G Thacker, Baikuntha Aryal

Pharm Res· November 2021

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CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis.
Seth G Thacker, Ian L McWilliams, Beatrice Bonnet, Lydia Halie, Serge Beaucage

PLoS Negl Trop Dis· February 2020

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Dietary α-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice.
Toshihiro Sakurai, Akiko Sakurai, Ye Chen, Boris L Vaisman, Marcelo J Amar, Seth G Thacker

Mol Nutr Food Res· August 2017

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Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.
Yasuko Furumoto, Carolyne K Smith, Luz Blanco, Wenpu Zhao, Stephen R Brooks, Seth G Thacker

Arthritis Rheumatol· January 2017

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High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.
Seth G Thacker, Abdalrahman Zarzour, Ye Chen, Mustafa S Alcicek, Lita A Freeman

Immunology· November 2016

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Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice.
Alexander V Sorokin, Zhi-Hong Yang, Boris L Vaisman, Seth Thacker, Zu-Xi Yu

J Nutr Biochem· September 2016

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Lipoprotein X Causes Renal Disease in LCAT Deficiency.
Alice Ossoli, Edward B Neufeld, Seth G Thacker, Boris Vaisman, Milton Pryor

PLoS One· July 2016

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Elevated interleukin-10: a new cause of dyslipidemia leading to severe HDL deficiency.
Andreas G Moraitis, Lita A Freeman, Robert D Shamburek, Robert Wesley, Wyndham Wilson, Seth G Thacker

J Clin Lipidol· October 2015

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The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties.
Anna Schwendeman, Denis O Sviridov, Wenmin Yuan, Yanhong Guo, Emily E Morin, Seth Thacker

J Lipid Res· September 2015

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Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.
Seth G Thacker, Xavier Rousset, Safiya Esmail, Abdalrahman Zarzour, Xueting Jin

J Lipid Res· July 2015

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Synthesis of cholesterol analogues bearing BODIPY fluorophores by Suzuki or Liebeskind-Srogl cross-coupling and evaluation of their potential for visualization of cholesterol pools.
Zheng Liu, Seth G Thacker, Sara Fernandez-Castillejo, Edward B Neufeld, Alan T Remaley

Chembiochem· September 2014

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Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.
Ling Guo, Zhong Zheng, Junting Ai, Deborah A Howatt, Paul R Mittelstadt, Seth Thacker

Arterioscler Thromb Vasc Biol· May 2014

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HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells.
Fatiha Tabet, Kasey C Vickers, Luisa F Cuesta Torres, Carrie B Wiese, Bassem M Shoucri, Seth Thacker

Nat Commun· February 2014

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Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis.
Seth G Thacker, Wenpu Zhao, Carolyne K Smith, Wei Luo, Hui Wang

Arthritis Rheum· September 2012

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Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus.
J Michelle Kahlenberg, Seth G Thacker, Celine C Berthier, Clemens D Cohen, Matthias Kretzler

J Immunol· December 2011

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The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.
Seth G Thacker, Celine C Berthier, Deborah Mattinzoli, Maria Pia Rastaldi, Matthias Kretzler

J Immunol· October 2010

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A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs.
Michael F Denny, Srilakshmi Yalavarthi, Wenpu Zhao, Seth G Thacker, Marc Anderson

J Immunol· March 2010

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