Publications by authors named "Shane Harding"

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Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection.
Emily Poulton, Ayeisha Desjardins, Shane M Harding, Lucie Malbeteau, Marianne Koritzinsky

Radiother Oncol· January 2026

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Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.
Alexandria DeCarlo, Graham MacLeod, Carolina Fernandes da Silva, Li Qing Shen, Julija Povilaikaite, Shane M Harding

Cell Rep Med· July 2025

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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33.
Sara Lamorte, Rene Quevedo, Robbie Jin, Luke Neufeld, Zhe Qi Liu, Shane Harding

Cancer Cell· May 2025

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A road to rupture: New insights into the loss of micronuclear membrane integrity.
Shane M Harding

Mol Cell· November 2024

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In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.
Peiran Su, Yin Liu, Tianyi Chen, Yibo Xue, Yong Zeng, Shane Harding

Nat Genet· September 2024

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The proteomic landscape of genotoxic stress-induced micronuclei.
Kate M MacDonald, Shahbaz Khan, Brian Lin, Rose Hurren, Aaron D Schimmer, Shane M Harding

Mol Cell· April 2024

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Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy.
Pinakin Pandya, Frank P Vendetti, Joseph El-Ghoubaira, Sudipta Pathak, Joshua J Deppas, Shane M Harding

bioRxiv· April 2024

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The entanglement of DNA damage and pattern recognition receptor signaling.
Cindy T Ha, Maha M Tageldein, Shane M Harding

DNA Repair (Amst)· January 2024

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Memory T Cells in the Immunoprevention of Cancer: A Switch from Therapeutic to Prophylactic Approaches.
Siddhesh Mittra, Shane M Harding, Susan M Kaech

J Immunol· September 2023

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Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei.
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding

Nat Commun· February 2023

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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Shane M Harding

Nat Cell Biol· June 2022

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Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21): 15-Year Evaluation of an Innovative Research Training Program.
Parasvi S Patel, Sobiga Vyravanathan, Emily Milne, Andrea Bezjak, Bradly G Wouters, Shane M Harding

Int J Radiat Oncol Biol Phys· July 2021

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Opposing Roles of Type I Interferons in Cancer Immunity.
Giselle M Boukhaled, Shane Harding, David G Brooks

Annu Rev Pathol· January 2021

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Alerting the immune system to DNA damage: micronuclei as mediators.
Kate M MacDonald, Soraya Benguerfi, Shane M Harding

Essays Biochem· October 2020

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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.
Jie Chen, Shane M Harding, Ramakrishnan Natesan, Lei Tian, Joseph L Benci

Cell Rep· September 2020

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Constricted migration increases DNA damage and independently represses cell cycle.
Charlotte R Pfeifer, Yuntao Xia, Kuangzheng Zhu, Dazhen Liu, Jerome Irianto, Shane Harding

Mol Biol Cell· August 2018

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Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn

Nature· August 2017

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DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.
Jerome Irianto, Yuntao Xia, Charlotte R Pfeifer, Avathamsa Athirasala, Jiazheng Ji, Shane M Harding

Curr Biol· January 2017

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Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture.
Shane M Harding, Roger A Greenberg

Front Genet· July 2016

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ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.
Shane M Harding, Jonathan A Boiarsky, Roger A Greenberg

Cell Rep· October 2015

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Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells.
Lei Cui, Kenneth Tse, Payam Zahedi, Shane M Harding, Gaetano Zafarana

Radiat Res· November 2014

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DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
Atsushi Shibata, Davide Moiani, Andrew S Arvai, Jefferson Perry, Shane M Harding

Mol Cell· January 2014

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Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.
Shane M Harding, Robert G Bristow

Cell Cycle· April 2012

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A role for p53 in the response of bystander cells to receipt of medium borne signals from irradiated cells.
Carmel Mothersill, Robert G Bristow, Shane M Harding, Richard W Smith, Anna Mersov

Int J Radiat Biol· November 2011

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ATM-dependent phosphorylation of 53BP1 in response to genomic stress in oxic and hypoxic cells.
Shane M Harding, Carla Coackley, Robert G Bristow

Radiother Oncol· June 2011

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