Publications by authors named "Shane Rea"

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Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan.
Tyler A U Hilsabeck, Shane L Rea

bioRxiv· May 2025

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Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency.
Megan B Borror, Milena Girotti, Adwitiya Kar, Meghan K Cain, Xiaoli Gao, Shane L Rea

Cells· May 2022

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BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in .
Alessandro Torgovnick, Alfonso Schiavi, Anjumara Shaik, Henok Kassahun, Silvia Maglioni, Shane L Rea

EMBO Rep· December 2018

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CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.
Adwitiya Kar, Haley Beam, Megan B Borror, Michael Luckow, Xiaoli Gao, Shane L Rea

PLoS One· August 2017

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DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.
Erin Munkácsy, Maruf H Khan, Rebecca K Lane, Megan B Borror, Jae H Park, Shane L Rea

PLoS Genet· July 2016

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Mitochondrial metabolites extend lifespan.
Robert J Mishur, Maruf Khan, Erin Munkácsy, Lokendra Sharma, Alex Bokov, Shane L Rea

Aging Cell· April 2016

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The role of mitochondrial dysfunction in age-related diseases.
Rebecca K Lane, Tyler Hilsabeck, Shane L Rea

Biochim Biophys Acta· November 2015

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L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Eun-Hee Shim, Carolina B Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Shane L Rea

Cancer Discov· November 2014

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The paradox of mitochondrial dysfunction and extended longevity.
Erin Munkácsy, Shane L Rea

Exp Gerontol· August 2014

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Exometabolomic mapping of Caenorhabditis elegans: a tool to noninvasively investigate aging.
Robert J Mishur, Jeffrey A Butler, Shane L Rea

Methods Mol Biol· March 2014

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TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
Maruf H Khan, Melissa Ligon, Lauren R Hussey, Bryce Hufnal, Robert Farber, Shane L Rea

Aging (Albany NY)· October 2013

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Profiling the anaerobic response of C. elegans using GC-MS.
Jeffrey A Butler, Robert J Mishur, Alex F Bokov, Kevin W Hakala, Susan T Weintraub, Shane L Rea

PLoS One· March 2013

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A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.
Jeffrey A Butler, Robert J Mishur, Shylesh Bhaskaran, Shane L Rea

Aging Cell· February 2013

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Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.
Alfonso Schiavi, Alessandro Torgovnick, Alison Kell, Evgenia Megalou, Natascha Castelein, Shane L Rea

Exp Gerontol· February 2013

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The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans.
Maruf H Khan, Matthew J Hart, Shane L Rea

Biochem Biophys Res Commun· August 2012

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Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases.
Robert J Mishur, Shane L Rea

Mass Spectrom Rev· April 2012

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Breaking Caenorhabditis elegans the easy way using the Balch homogenizer: an old tool for a new application.
Shylesh Bhaskaran, Jeffrey A Butler, Sandra Becerra, Veronica Fassio, Milena Girotti, Shane L Rea

Anal Biochem· June 2011

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Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases.
Shane L Rea, Brett H Graham, Eiko Nakamaru-Ogiso, Adwitiya Kar, Marni J Falk

Dev Disabil Res Rev· January 2011

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Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.
Jeffrey A Butler, Natascia Ventura, Thomas E Johnson, Shane L Rea

FASEB J· December 2010

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Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.
Deqing Wu, Shane L Rea, James R Cypser, Thomas E Johnson

Aging Cell· December 2009

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p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.
Natascia Ventura, Shane L Rea, Alfonso Schiavi, Alessandro Torgovnick, Roberto Testi

Aging Cell· August 2009

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Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.
Nate W Kahn, Shane L Rea, Sarah Moyle, Alison Kell, Thomas E Johnson

Biochem J· January 2008

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Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.
Shane L Rea, Natascia Ventura, Thomas E Johnson

PLoS Biol· October 2007

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Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction.
Natascia Ventura, Shane L Rea

Biotechnol J· May 2007

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Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases.
Natascia Ventura, Shane L Rea, Roberto Testi

Exp Gerontol· October 2006

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