Publications by authors named "Shanthakumar Tyavanagimatt"

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Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis.
Prasad R Kopparapu, Christiane V Löhr, Martin C Pearce, Shanthakumar Tyavanagimatt, Harikrishna Nakshatri

ACS Pharmacol Transl Sci· May 2024

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Identification and Characterization of a Small Molecule Bcl-2 Functional Converter.
Prasad R Kopparapu, Martin C Pearce, Christiane V Löhr, Cathy Duong, Hyo Sang Jang, Shanthakumar Tyavanagimatt

Cancer Res Commun· March 2024

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Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis.
Stephen T Oh, Ruben A Mesa, Claire N Harrison, Prithviraj Bose, Aaron T Gerds, Shanthakumar Tyavanagimatt

Blood Adv· October 2023

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Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis.
Aaron T Gerds, Michael R Savona, Bart L Scott, Moshe Talpaz, Miklos Egyed, Shanthakumar Tyavanagimatt

Blood Adv· November 2020

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A potent Lassa virus antiviral targets an arenavirus virulence determinant.
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Shanthakumar R Tyavanagimatt

PLoS Pathog· December 2018

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Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
Adams Amantana, Yali Chen, Shanthakumar R Tyavanagimatt, Kevin F Jones, Robert Jordan

PLoS One· December 2013

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Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Chelsea M Byrd, Douglas W Grosenbach, Aklile Berhanu, Dongcheng Dai, Kevin F Jones, Shanthakumar Tyavanagimatt

Antimicrob Agents Chemother· April 2013

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Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Janet M Leeds, Frederique Fenneteau, Nathalie H Gosselin, Mohamad-Samer Mouksassi, Nastya Kassir, Shanthakumar R Tyavanagimatt

Antimicrob Agents Chemother· March 2013

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A novel inhibitor of dengue virus replication that targets the capsid protein.
Chelsea M Byrd, Dongcheng Dai, Douglas W Grosenbach, Aklile Berhanu, Kevin F Jones, Shanthakumar Tyavanagimatt

Antimicrob Agents Chemother· January 2013

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Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Jarasvech Chinsangaram, Kady M Honeychurch, Shanthakumar R Tyavanagimatt, Janet M Leeds, Tove' C Bolken

Antimicrob Agents Chemother· September 2012

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Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
Jarasvech Chinsangaram, Kady M Honeychurch, Shanthakumar R Tyavanagimatt, Tove' C Bolken, Robert Jordan

Antimicrob Agents Chemother· July 2012

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SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.
James R Burgeson, Amy L Moore, Jordan K Boutilier, Natasha R Cerruti, Dima N Gharaibeh, Shanthakumar R Tyavanagimatt

Bioorg Med Chem Lett· July 2012

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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
Yali Chen, Adams Amantana, Shanthakumar R Tyavanagimatt, Daniela Zima, X Steven Yan

PLoS One· February 2012

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Development of ST-246® for Treatment of Poxvirus Infections.
Robert Jordan, Janet M Leeds, Shanthakumar Tyavanagimatt, Dennis E Hruby

Viruses· November 2010

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Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Robert Jordan, Jarasvech Chinsangaram, Tove' C Bolken, Shanthakumar R Tyavanagimatt, Deborah Tien

Antimicrob Agents Chemother· June 2010

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ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Robert Jordan, Arthur Goff, Annie Frimm, Michael L Corrado, Lisa E Hensley, Shanthakumar Tyavanagimatt

Antimicrob Agents Chemother· May 2009

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Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
Robert Jordan, Deborah Tien, Tove' C Bolken, Kevin F Jones, Shanthakumar R Tyavanagimatt

Antimicrob Agents Chemother· May 2008

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Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
Douglas W Grosenbach, Robert Jordan, David S King, Aklile Berhanu, Travis K Warren, Shanthakumar Tyavanagimatt

Vaccine· February 2008

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