Publications by authors named "Sharon Cantor"

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RAD51 is chromatin enriched and targetable in BRCA1-deficient cells.
Min Peng, Silviana Lee, Hitha Gopalan Nair, Nathan MacGilvary, Ke Cong, Sharon B Cantor

Mol Cell· September 2025

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Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability.
Jenna M Whalen, Jillian Earley, Christi Silva, Arthur M Mercurio, Sharon B Cantor

Nat Cancer· February 2025

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Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer.
Nathan MacGilvary, Sharon B Cantor

DNA Repair (Amst)· December 2024

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Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction.
Angela M Zaino, Radha Charan Dash, Stephy J James, Nathan MacGilvary, Andrew Crompton, Sharon B Cantor

Bioorg Med Chem· May 2024

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells.
Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Sharon B Cantor

Nat Commun· March 2024

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells.
Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Sharon B Cantor

bioRxiv· January 2024

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Unveiling the toxicity of single-stranded DNA gaps through a yeast model.
Jenna M Whalen, Sharon B Cantor

Nat Struct Mol Biol· July 2023

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Exploiting replication gaps for cancer therapy.
Ke Cong, Sharon B Cantor

Mol Cell· July 2022

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Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer".
Sharon B Cantor

DNA Repair (Amst)· November 2021

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Mariana Paes Dias, Vivek Tripathi, Ingrid van der Heijden, Ke Cong, Eleni-Maria Manolika, Sharon Cantor

Mol Cell· November 2021

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Ke Cong, Min Peng, Arne Nedergaard Kousholt, Wei Ting C Lee, Silviana Lee, Sharon B Cantor

Mol Cell· August 2021

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Ke Cong, Min Peng, Arne Nedergaard Kousholt, Wei Ting C Lee, Silviana Lee, Sharon B Cantor

Mol Cell· August 2021

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Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.
Jennifer A Calvo, Briana Fritchman, Desiree Hernandez, Nicole S Persky, Cory M Johannessen, Sharon B Cantor

Mol Cancer Res· June 2021

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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.
Wei Ting C Lee, Yandong Yin, Michael J Morten, Peter Tonzi, Pam Pam Gwo, Sharon B Cantor

Nat Commun· May 2021

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Replication Gaps Underlie BRCA Deficiency and Therapy Response.
Nicholas J Panzarino, John J Krais, Ke Cong, Min Peng, Michelle Mosqueda, Sharon B Cantor

Cancer Res· March 2021

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Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability.
Sumeet Nayak, Jennifer A Calvo, Sharon B Cantor

Expert Opin Ther Targets· January 2021

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FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.
Sanket Awate, Joshua A Sommers, Arindam Datta, Sumeet Nayak, Marina A Bellani, Sharon B Cantor

Nucleic Acids Res· September 2020

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Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability.
Sumeet Nayak, Jennifer A Calvo, Ke Cong, Min Peng, Emily Berthiaume, Sharon B Cantor

Sci Adv· June 2020

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TPX2 joins 53BP1 to maintain DNA repair and fork stability.
Sharon Cantor

J Cell Biol· February 2019

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Min Peng, Ke Cong, Nicholas J Panzarino, Sumeet Nayak, Jennifer Calvo, Sharon B Cantor

Cell Rep· September 2018

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Fork Protection and Therapy Resistance in Hereditary Breast Cancer.
Sharon B Cantor, Jennifer A Calvo

Cold Spring Harb Symp Quant Biol· February 2018

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Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer.
Yue Wang, Matthew H Ung, Sharon Cantor, Chao Cheng

Sci Rep· November 2017

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Impairment of fetal hematopoietic stem cell function in the absence of Fancd2.
Sakiko Suzuki, Ronny R Racine, Nathan A Manalo, Sharon B Cantor, Glen D Raffel

Exp Hematol· April 2017

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Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Sharon B Cantor

Nature· November 2016

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Replication fork stability confers chemoresistance in BRCA-deficient cells.
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Sharon B Cantor

Nature· July 2016

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