Publications by authors named "Sharon Sagan"

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Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
Lena K Siewert, Kristina Berve, Elisabeth Pössnecker, Julia Dyckow, Amel Zulji, Sharon Sagan

Gut Microbes· December 2026

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Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry.
Carson E Moseley, Sharon Sagan, Juliano A Boquett, Collin M Spencer, Jill A Hollenbach

Neurol Neuroimmunol Neuroinflamm· January 2026

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Programming tissue-sensing T cells that deliver therapies to the brain.
Milos S Simic, Payal B Watchmaker, Sasha Gupta, Yuan Wang, Sharon A Sagan

Science· December 2024

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High-yield production of recombinant human myelin oligodendrocyte glycoprotein in SHuffle bacteria without a refolding step.
Wesley Wu, Sasha Gupta, Sharon A Sagan, Carson E Moseley, Scott S Zamvil

J Immunol Methods· November 2024

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T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
Sharon A Sagan, Zahra Moinfar, Carson E Moseley, Ravi Dandekar, Collin M Spencer

Proc Natl Acad Sci U S A· July 2023

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CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Sasha Gupta, Milos Simic, Sharon A Sagan, Chanelle Shepherd, Jason Duecker

Neurol Neuroimmunol Neuroinflamm· March 2023

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Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1-phosphate receptor modulators.
Joseph J Sabatino, Kristen Mittl, William Rowles, Colin R Zamecnik, Rita P Loudermilk, Sharon A Sagan

Mult Scler Relat Disord· February 2023

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Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.
Joseph J Sabatino, Kristen Mittl, William M Rowles, Kira McPolin, Jayant V Rajan, Sharon A Sagan

JCI Insight· February 2022

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Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis.
Frederik Novak, Anna Christine Nilsson, Christian Nielsen, Dorte K Holm, Kamilla Østergaard, Sharon Sagan

Mult Scler Relat Disord· November 2021

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Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity.
Joseph J Sabatino, Kristen Mittl, William Rowles, Kira Mcpolin, Jayant V Rajan, Sharon A Sagan

medRxiv· September 2021

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.
Sharon A Sagan, Andrés Cruz-Herranz, Collin M Spencer, Peggy P Ho, Lawrence Steinman

J Vis Exp· August 2017

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T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.
Andrés Cruz-Herranz, Sharon A Sagan, Raymond A Sobel, Ari J Green, Scott S Zamvil

J Nat Sci· May 2017

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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
Sharon A Sagan, Ryan C Winger, Andrés Cruz-Herranz, Patricia A Nelson, Sarah Hagberg

Proc Natl Acad Sci U S A· December 2016

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B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.
Klaus Lehmann-Horn, Sheng-Zhi Wang, Sharon A Sagan, Scott S Zamvil, H-Christian von Büdingen

JCI Insight· December 2016

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CNS accumulation of regulatory B cells is VLA-4-dependent.
Klaus Lehmann-Horn, Sharon A Sagan, Ryan C Winger, Collin M Spencer, Claude C A Bernard

Neurol Neuroimmunol Neuroinflamm· April 2016

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Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
Ulf Schulze-Topphoff, Michel Varrin-Doyer, Kara Pekarek, Collin M Spencer, Aparna Shetty, Sharon A Sagan

Proc Natl Acad Sci U S A· April 2016

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B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
Klaus Lehmann-Horn, Sharon A Sagan, Claude C A Bernard, Raymond A Sobel, Scott S Zamvil

Ann Neurol· May 2015

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Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.
Ulf Schulze-Topphoff, Aparna Shetty, Michel Varrin-Doyer, Nicolas Molnarfi, Sharon A Sagan

PLoS One· November 2012

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