Publications by authors named "Sharyn D Baker"

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Drug-drug interactions in targeted cancer therapies: a focus on tyrosine kinase inhibitors.
Jack C Stromatt, Anika T Chowdhury, Kevin M Huang, Shuiying Hu, Alex Sparreboom, Sharyn D Baker

Expert Rev Clin Pharmacol· December 2025

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Drug-Drug Interaction Liabilities with BTK Inhibitor TL-895.
Jack C Stromatt, Eman A Ahmed, Thomas Drabison, Mahesh R Nepal, Anika T Chowdhury, Sharyn D Baker

Cancer Res Commun· September 2025

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A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.
Eric D Eisenmann, Ronan Swords, Ying Huang, Shelley Orwick, Daelynn Buelow, Sharyn D Baker

Cancer Res Commun· July 2025

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TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment.
Pu Zhang, Ethan C Whipp, Sarah J Skuli, Mehdi Gharghabi, Caner Saygin, Sharyn D Baker

J Clin Invest· May 2025

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Prognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies.
Nadeen Anabtawi, Deedra Nicolet, Najla Alotaibi, Daelynn R Buelow, Shelley Orwick, Sharyn D Baker

Leukemia· March 2025

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Genomewide Screen Identifies Peroxisomal Role in APOL1 Podocytopathy.
Jiyoung Kim, Isaac Z Karel, Huijuan Song, Megan Dewalt, Shelley Orwick, Sharyn D Baker

medRxiv· February 2025

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Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen.
Thomas Drabison, Mike Boeckman, Yan Yang, Kevin M Huang, Peter de Bruijn, Sharyn D Baker

Cancer Res Commun· September 2024

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Pharmacokinetic assessment of low dose decitabine in combination therapies: Development and validation of a sensitive UHPLC-MS/MS method for murine plasma analysis.
Nadeen Anabtawi, Thomas Drabison, Yan Jin, Eric D Eisenmann, Alex Sparreboom, Sharyn D Baker

J Chromatogr B Analyt Technol Biomed Life Sci· July 2024

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Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia.
Ola A Elgamal, Sydney Fobare, Sandip Vibhute, Abeera Mehmood, Dennis C Vroom, Sharyn D Baker

JCI Insight· April 2024

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A new genomic framework to categorize pediatric acute myeloid leukemia.
Masayuki Umeda, Jing Ma, Tamara Westover, Yonghui Ni, Guangchun Song, Sharyn D Baker

Nat Genet· February 2024

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Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.
Yang Li, Yasuhiro Kazuki, Thomas Drabison, Kaoru Kobayashi, Ken-Ichi Fujita, Sharyn D Baker

Drug Metab Dispos· January 2024

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DNA methyltransferase inhibitor exposure-response: Challenges and opportunities.
Amanda B Kagan, Dominique A Garrison, Nicole M Anders, Jonathan A Webster, Sharyn D Baker

Clin Transl Sci· August 2023

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Framework of clonal mutations concurrent with WT1 mutations in adults with acute myeloid leukemia: Alliance for Clinical Trials in Oncology study.
Bhavana Bhatnagar, Jessica Kohlschmidt, Shelley J Orwick, Daelynn R Buelow, Sydney Fobare, Sharyn D Baker

Blood Adv· August 2023

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Targeting a xenobiotic transporter to ameliorate vincristine-induced sensory neuropathy.
Yang Li, Thomas Drabison, Mahesh Nepal, Richard H Ho, Alix F Leblanc, Sharyn D Baker

JCI Insight· July 2023

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Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice.
Avinash K Persaud, Matthew C Bernier, Michael A Massey, Shipra Agrawal, Tejinder Kaur, Sharyn D Baker

Nat Commun· June 2023

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Author Correction: Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice.
Avinash K Persaud, Matthew C Bernier, Michael A Massey, Shipra Agrawal, Tejinder Kaur, Sharyn D Baker

Nat Commun· June 2023

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Testing: Time to Put Patient Safety First.
Sharyn D Baker, Susan E Bates, Gabriel A Brooks, William L Dahut, Robert B Diasio

J Clin Oncol· May 2023

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Determination and disposition of meta-iodobenzylguanidine in plasma and heart of transporter-deficient mice by UPLC-MS/MS.
Zahra Talebi, Yan Jin, Sharyn D Baker, Daniel Addison, Alex Sparreboom

J Chromatogr B Analyt Technol Biomed Life Sci· May 2023

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Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis.
Masayuki Umeda, Jing Ma, Tamara Westover, Yonghui Ni, Guangchun Song, Sharyn D Baker

Res Sq· May 2023

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TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with Mutation/Deletion.
Eric D Eisenmann, Jack C Stromatt, Sydney Fobare, Kevin M Huang, Daelynn R Buelow, Sharyn D Baker

Cancers (Basel)· December 2022

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Determination of the endogenous OATP1B biomarkers glycochenodeoxycholate-3-sulfate and chenodeoxycholate-24-glucuronide in human and mouse plasma by a validated UHPLC-MS/MS method.
Yan Jin, Yang Li, Eric D Eisenmann, William D Figg, Sharyn D Baker

J Chromatogr B Analyt Technol Biomed Life Sci· November 2022

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Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B.
Dominique A Garrison, Yan Jin, Zahra Talebi, Shuiying Hu, Alex Sparreboom, Sharyn D Baker

Molecules· October 2022

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BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors.
Daelynn R Buelow, Bhavana Bhatnagar, Shelley J Orwick, Jae Yoon Jeon, Eric D Eisenmann, Sharyn D Baker

Blood Adv· September 2022

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A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug-Drug Interaction Liabilities.
Yang Li, Yan Jin, Hanieh Taheri, Keith T Schmidt, Alice A Gibson, Sharyn D Baker

Pharmaceutics· September 2022

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Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination.
Eric D Eisenmann, Dominique A Garrison, Zahra Talebi, Yan Jin, Josie A Silvaroli, Sharyn D Baker

Pharmaceutics· March 2022

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