Publications by authors named "Sheila Fleming"

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Phenotype Differences Between ATP13A2 Heterozygous and Knockout Mice Across Aging.
Kristina Croucher, Josephine K Lepp, Jennifer Bechtold, Edward J Hamad, Sophia Scott, Sheila M Fleming

Int J Mol Sci· July 2025

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Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function.
Sheila M Fleming, Sophia Scott, Edward J Hamad, Danielle E Herman, John G Holden

Front Neurosci· April 2025

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ATP13A2 (PARK9) and basal ganglia function.
Kristina M Croucher, Sheila M Fleming

Front Neurol· January 2024

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Cognitive dysfunction and increased phosphorylated tau are associated with reduced O-GlcNAc signaling in an aging mouse model of metabolic syndrome.
Shreya Gupta, Sanjay K A Jinka, Saugat Khanal, Neha Bhavnani, Fayez Almashhori, Sheila M Fleming

J Neurosci Res· August 2023

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iPSC-derived neural precursor cells engineering recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology.
Yanyan Peng, Benjamin Liou, Yi Lin, Christopher N Mayhew, Sheila M Fleming

Mol Ther Methods Clin Dev· June 2023

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Role of rodent models in advancing precision medicine for Parkinson's disease.
Emily Simons, Sheila M Fleming

Handb Clin Neurol· February 2023

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Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies.
Sheila M Fleming, Ashley Davis, Emily Simons

Neuropharmacology· January 2022

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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.
Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming

Neuropathol Appl Neurobiol· December 2021

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Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease.
Eileen Ruth S Torres, Milos Stanojlovic, Moriel Zelikowsky, Jana Bonsberger, Sindalana Hean, Sheila Fleming

Neurobiol Dis· October 2021

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Systemic Copper Disorders Influence the Olfactory Function in Adult Rats: Roles of Altered Adult Neurogenesis and Neurochemical Imbalance.
Sherleen Xue-Fu Adamson, Wei Zheng, Zeynep Sena Agim, Sarah Du, Sheila Fleming

Biomolecules· September 2021

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Acoustilytix™: A Web-Based Automated Ultrasonic Vocalization Scoring Platform.
Catherine B Ashley, Ryan D Snyder, James E Shepherd, Catalina Cervantes, Nitish Mittal, Sheila Fleming

Brain Sci· June 2021

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Farey Trees Explain Sequential Effects in Choice Response Time.
Colin T Annand, Sheila M Fleming, John G Holden

Front Physiol· March 2021

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Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis.
Naveen K Singhal, Sarah Sternbach, Sheila Fleming, Kholoud Alkhayer, John Shelestak

Epigenetics· August 2020

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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Aysegul O Gezer, Joseph Kochmanski, Sarah E VanOeveren, Allyson Cole-Strauss, Christopher J Kemp, Sheila M Fleming

Neurobiol Dis· July 2020

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Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.
Matthew L Neal, Sheila M Fleming, Kevin M Budge, Alexa M Boyle, Chunki Kim

FASEB J· January 2020

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Correction: Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Jessica M Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D Camino, Serene W Chen, Sheila Fleming

J Biol Chem· January 2020

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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.
Joseph R Patterson, Megan F Duffy, Christopher J Kemp, Jacob W Howe, Timothy J Collier, Sheila M Fleming

Neurobiol Dis· October 2019

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Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Jessica M Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D Camino, Serene W Chen, Sheila Fleming

J Biol Chem· July 2019

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Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Emily R Dirr, Osunde R Ekhator, Rachel Blackwood, John G Holden, Eliezer Masliah, Sheila M Fleming

Behav Brain Res· May 2018

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Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls.
Breann T Colter, Helen Frances Garber, Sheila M Fleming, Jocelyn Phillips Fowler, Gregory D Harding

Neurotoxicology· March 2018

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The effect of manganese exposure in Atp13a2-deficient mice.
Sheila M Fleming, Nicholas A Santiago, Elizabeth J Mullin, Shanta Pamphile, Swagata Karkare

Neurotoxicology· January 2018

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Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
Sheila M Fleming

Curr Environ Health Rep· June 2017

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Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Benjamin Liou, Yanyan Peng, Ronghua Li, Venette Inskeep, Wujuan Zhang, Sheila Fleming

Hum Mol Genet· December 2016

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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.
Katrina L Paumier, Kelvin C Luk, Fredric P Manfredsson, Nicholas M Kanaan, Jack W Lipton, Sheila Fleming

Neurobiol Dis· October 2015

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Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein.
Iddo Magen, Regina Ostritsky, Franziska Richter, Chunni Zhu, Sheila M Fleming

Pharmacol Res Perspect· October 2014

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