Publications by authors named "Shing-Leng Chan"

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Clinical translation of patient-derived tumour organoids- bottlenecks and strategies.
Malia Alexandra Foo, Mingliang You, Shing Leng Chan, Gautam Sethi, Glenn K Bonney

Biomark Res· March 2022

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Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β.
Wen Min Lau, Eileen Teng, Kie Kyon Huang, Jin Wei Tan, Kakoli Das, Shing Leng Chan

Mol Cancer Ther· January 2018

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Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.
Noriyuki Kasai, Aya Sasakawa, Kenta Hosomi, Tze Wei Poh, Bernadette Lynn Chua, Shing Leng Chan

Am J Transl Res· July 2017

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BCL6 promotes glioma and serves as a therapeutic target.
Liang Xu, Ye Chen, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Shing-Leng Chan

Proc Natl Acad Sci U S A· April 2017

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The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Jun Ueda, Jolene Caifeng Ho, Kian Leong Lee, Shojiro Kitajima, Henry Yang, Shing Leng Chan

Mol Cell Biol· October 2014

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A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.
Yit Teng Hor, Dominic Chih-Cheng Voon, Jason Kin Wai Koo, Huajing Wang, Wen Min Lau, Shing Leng Chan

Cell Rep· July 2014

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CD44v8-10 is a cancer-specific marker for gastric cancer stem cells.
Wen Min Lau, Eileen Teng, Hui Shan Chong, Kirsten Anne Pagaduan Lopez, Amy Yuh Ling Tay, Shing Leng Chan

Cancer Res· May 2014

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Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.
Dominic Chih-Cheng Voon, Huajing Wang, Jason Kin Wai Koo, Tu Anh Pham Nguyen, Yit Teng Hor, Shing Leng Chan

Stem Cells· October 2012

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RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells.
M Cecilia Subauste, Tereza Ventura-Holman, Liqin Du, Jose S Subauste, Shing-Leng Chan

Cancer Biol Ther· December 2009

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Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions.
Li-Fong Seet, Eileen Teng, Yih-Shin Lai, Joseph Laning, Morey Kraus, Shing Leng Chan

Eur J Haematol· February 2009

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Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.
Kah Fei Wan, Shing-Leng Chan, Sunil Kumar Sukumaran, Mei-Chin Lee, Victor C Yu

J Biol Chem· March 2008

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Enhanced in vivo homing of uncultured and selectively amplified cord blood CD34+ cells by cotransplantation with cord blood-derived unrestricted somatic stem cells.
Shing Leng Chan, Michael Choi, Stephan Wnendt, Morey Kraus, Eileen Teng

Stem Cells· February 2007

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Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.
Yong-Hong Zhang, Anirban Bhunia, Kah Fei Wan, Mei Chin Lee, Shing-Leng Chan

J Mol Biol· December 2006

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MAP-1 is a mitochondrial effector of Bax.
Kuan Onn Tan, Nai Yang Fu, Sunil K Sukumaran, Shing-Leng Chan, Jiunn Hian Kang

Proc Natl Acad Sci U S A· October 2005

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Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities.
Shing-Leng Chan, Victor C Yu

Clin Exp Pharmacol Physiol· March 2004

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Identification of chelerythrine as an inhibitor of BclXL function.
Shing-Leng Chan, Mei Chin Lee, Kuan Onn Tan, Lay-Kien Yang, Alex S Y Lee

J Biol Chem· June 2003

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