Publications by authors named "Shoki Okuda"

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Development and validation of the Delirium Burden Scale for Healthcare Providers (DBS-HCP).
Naoya Ueda, Ichiro Tazaki, Michael LoPresti, Yukiko Shibuya, Shigeru Tokita, Shoki Okuda

PCN Rep· December 2025

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Factors Associated with Prescriptions for an Orexin Receptor Antagonist Among Japanese Patients with Insomnia: Analysis of a Nationwide Japanese Claims Database.
Shoki Okuda, Zaina P Qureshi, Yukiko Yanagida, Chie Ito, Yuji Homma

Drugs Real World Outcomes· June 2023

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Hypnotic prescription trends and patterns for the treatment of insomnia in Japan: analysis of a nationwide Japanese claims database.
Shoki Okuda, Zaina P Qureshi, Yukiko Yanagida, Chie Ito, Yuji Homma

BMC Psychiatry· April 2023

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Incremental medical cost of delirium in elderly patients with cognitive impairment: analysis of a nationwide administrative database in Japan.
Masakazu Igarashi, Kotoba Okuyama, Naoya Ueda, Hideki Sano, Kanae Takahashi, Shoki Okuda

BMJ Open· December 2022

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Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database.
Naoya Ueda, Masakazu Igarashi, Kotoba Okuyama, Hideki Sano, Kanae Takahashi, Shoki Okuda

BMJ Open· September 2022

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Association between sleep disturbance in Alzheimer's disease patients and burden on and health status of their caregivers.
Shoki Okuda, Jumpei Tetsuka, Kenichi Takahashi, Yasuo Toda, Takekazu Kubo

J Neurol· June 2019

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Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.
Hideyuki Igawa, Vladimir Stepanov, Lenke Tari, Shoki Okuda, Syunsuke Yamamoto

Curr Radiopharm· February 2018

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Podocan Is Expressed in Blood and Adipose Tissue and Correlates Negatively With the Induction of Diabetic Nephropathy.
Yasunori Nio, Mitsugi Okawara, Shoki Okuda, Takanori Matsuo, Naoki Furuyama

J Endocr Soc· July 2017

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A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.
Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Shoki Okuda

Endocrinology· May 2017

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A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
Yayoi Kawata, Shoki Okuda, Natsu Hotta, Hideyuki Igawa, Masashi Takahashi

Eur J Pharmacol· February 2017

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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.
Hideyuki Igawa, Masashi Takahashi, Mikio Shirasaki, Keiko Kakegawa, Asato Kina, Shoki Okuda

Bioorg Med Chem· June 2016

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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Hideyuki Igawa, Masashi Takahashi, Minoru Ikoma, Hiromi Kaku, Keiko Kakegawa, Shoki Okuda

Bioorg Med Chem· June 2016

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Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions.
Shunsuke Maehara, Shoki Okuda, Hisashi Ohta

Brain Res Bull· October 2011

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Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents.
Hirohiko Hikichi, Takeshi Murai, Shoki Okuda, Shunsuke Maehara, Akio Satow

Eur J Pharmacol· August 2010

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Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist.
Kensuke Kobayashi, Tomohiro Tsujita, Hirokatsu Ito, Satoshi Ozaki, Takeshi Tani, Shoki Okuda

Bioorg Med Chem Lett· August 2009

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Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.
Atsushi Satoh, Takeshi Sagara, Hiroki Sakoh, Masaya Hashimoto, Hiroshi Nakashima, Shoki Okuda

J Med Chem· July 2009

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Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia.
Shunsuke Maehara, Hirohiko Hikichi, Akio Satow, Shoki Okuda, Hisashi Ohta

Pharmacol Biochem Behav· November 2008

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Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor.
Satoko Ise, Norihiro Nagano, Shoki Okuda, Hisashi Ohta

Brain Res· October 2008

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A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel.
Takashi Yoshizumi, Hirobumi Takahashi, Hiroshi Miyazoe, Yuichi Sugimoto, Tomohiro Tsujita, Shoki Okuda

J Med Chem· July 2008

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Characteristics of object location memory in mice: Behavioral and pharmacological studies.
Takeshi Murai, Shoki Okuda, Takeshi Tanaka, Hisashi Ohta

Physiol Behav· January 2007

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Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala.
Benno Roozendaal, Shoki Okuda, Eddy A Van der Zee, James L McGaugh

Proc Natl Acad Sci U S A· April 2006

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Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
Yasuhiro Goto, Sachie Arai-Otsuki, Yukari Tachibana, Daisuke Ichikawa, Satoshi Ozaki, Shoki Okuda

J Med Chem· February 2006

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Insular cortex is involved in consolidation of object recognition memory.
Federico Bermudez-Rattoni, Shoki Okuda, Benno Roozendaal, James L McGaugh

Learn Mem· January 2006

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Glucocorticoid effects on object recognition memory require training-associated emotional arousal.
Shoki Okuda, Benno Roozendaal, James L McGaugh

Proc Natl Acad Sci U S A· January 2004

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