Publications by authors named "Shoukat Dedhar"

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Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death.
Gioele Renzi, Paul C McDonald, Shannon Awrey, Hossein Tavakoli, Zahra Bokhari, Shoukat Dedhar

Eur J Med Chem· December 2025

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"Several birds with one stone": exploring the potential of AI methods for multi-target drug design.
Muhetaer Mukaidaisi, Madiha Ahmed, Karl Grantham, Aws Al-Jumaily, Shoukat Dedhar

Mol Divers· August 2025

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Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.
Rocky Shi, Dylan A Farnsworth, Christopher A Febres-Aldana, Justine L M Chow, Ravinder Sheena, Shoukat Dedhar

Oncogene· August 2025

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Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis.
Paul C McDonald, James T Topham, Shannon Awrey, Hossein Tavakoli, Rebekah Carroll, Shoukat Dedhar

Commun Biol· July 2025

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Identification of intratumoral bacteria that enhance breast tumor metastasis.
Zachary J Gerbec, Antonio Serapio-Palacios, Avril Metcalfe-Roach, Zakhar Krekhno, Haggai Bar-Yoseph, Shoukat Dedhar

mBio· March 2025

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Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.
Naohide Fujita, Andrew Bondoc, Sergio Simoes, Joji Ishida, Michael S Taccone, Shoukat Dedhar

Brain Tumor Pathol· October 2024

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Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.
Hassan A Ali, Joanna M Karasinska, James T Topham, Danisha Johal, Steve Kalloger, Shoukat Dedhar

Cancer Metab· October 2024

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PrP controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up.
Claire Lailler, Audrey Didelot, Simon Garinet, Hugo Berthou, Marine Sroussi, Shoukat Dedhar

Oncogene· September 2024

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Persister cell plasticity in tumour drug resistance.
Paul C McDonald, Shoukat Dedhar

Semin Cell Dev Biol· March 2024

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Co-vulnerabilities of inhibiting carbonic anhydrase IX in ferroptosis-mediated tumor cell death.
Paul C McDonald, Shoukat Dedhar

Front Mol Biosci· November 2023

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A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells.
Geetha Venkateswaran, Paul C McDonald, Shawn C Chafe, Wells S Brown, Zachary J Gerbec, Shoukat Dedhar

Mol Cancer Ther· October 2023

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Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside.
Paul C McDonald, Shawn C Chafe, Claudiu T Supuran, Shoukat Dedhar

Cancers (Basel)· July 2022

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New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis.
Paul C McDonald, Shoukat Dedhar

Cancers (Basel)· June 2022

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Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX.
Anne E G Lenferink, Paul C McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Shoukat Dedhar

MAbs· April 2022

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Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.
Joey G Sheff, John F Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Shoukat Dedhar

MAbs· April 2022

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Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking.
Megan I Brasher, Shawn C Chafe, Paul C McDonald, Oksana Nemirovsky, Genya Gorshtein, Shoukat Dedhar

Mol Cancer Res· March 2022

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Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition.
Jing Yang, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Shoukat Dedhar

Nat Rev Mol Cell Biol· December 2021

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Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma.
Tilman Todenhöfer, Ewan A Gibb, Roland Seiler, Alireza Kamyabi, Jörg Hennenlotter, Shoukat Dedhar

Urol Oncol· August 2021

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Prognostic value of the PrP-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype.
Alexandre Ghazi, Delphine Le Corre, Camilla Pilati, Julien Taieb, Thomas Aparicio, Shoukat Dedhar

Oncoimmunology· August 2021

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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Shawn C Chafe, Frederick S Vizeacoumar, Geetha Venkateswaran, Oksana Nemirovsky, Shannon Awrey, Shoukat Dedhar

Sci Adv· August 2021

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Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints.
Shawn C Chafe, Nazia Riaz, Samantha Burugu, Dongxia Gao, Samuel C Y Leung, Shoukat Dedhar

Cancers (Basel)· March 2021

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Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.
Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Shoukat Dedhar

Biophys J· January 2021

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Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment.
Geetha Venkateswaran, Shoukat Dedhar

Front Cell Dev Biol· November 2020

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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer.
Wells S Brown, Paul C McDonald, Oksana Nemirovsky, Shannon Awrey, Shawn C Chafe, Shoukat Dedhar

Cell Rep Med· November 2020

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Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.
Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Shoukat Dedhar

Metabolites· October 2020

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