Publications by authors named "Sigen A"

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E
Enzymatically Activatable Polymers for Disease Diagnosis and Treatment.
Bin Ma, Jiahao Shi, Yuhe Zhang, Zhili Li, Haiyang Yong

Adv Mater· October 2024

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Fast one-step acrylate functionalization of hyaluronic acid Williamson ether synthesis.
Cameron Milne, Rijian Song, Runqi Zhu, Melissa Johnson, Chunyu Zhao

Chem Commun (Camb)· September 2024

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Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models.
Irene Lara-Sáez, Ángeles Mencía, Enrique Recuero, Yinghao Li, Marta García

Proc Natl Acad Sci U S A· July 2024

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Hyaluronic Acid/Chondroitin Sulfate-Based Dynamic Thiol-Aldehyde Addition Hydrogel: An Injectable, Self-Healing, On-Demand Dissolution Wound Dressing.
Melissa Johnson, Rijian Song, Yinghao Li, Cameron Milne, Jing Lyu

Materials (Basel)· June 2024

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Cyclization-enhanced poly(β-amino ester)s vectors for efficient CRISPR gene editing therapy.
Xianqing Wang, Yinghao Li, Sigen A, Jing Lyu, Xi Wang

J Control Release· April 2024

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Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives.
Cameron Milne, Rijian Song, Melissa Johnson, Chunyu Zhao, Francesca Santoro Ferrer

Biomacromolecules· April 2024

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Biphasic release of betamethasone from an injectable HA hydrogel implant for alleviating lumbar disc herniation induced sciatica.
Lunhao Chen, Chao Jiang, Qian Xu, Jiale Jin, Sigen A

Acta Biomater· March 2024

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Backbone cationized highly branched poly(β-amino ester)s as enhanced delivery vectors in non-viral gene therapy.
Yinghao Li, Bei Qiu, Zishan Li, Xianqing Wang, Zhonglei He

J Control Release· March 2024

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Smart biodegradable hydrogels: Drug-delivery platforms for treatment of chronic ophthalmic diseases affecting the back of the eye.
Alba Aragón-Navas, José Javier López-Cano, Melissa Johnson, Sigen A, Marta Vicario-de-la-Torre

Int J Pharm· January 2024

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CRISPR-Cas9-based non-viral gene editing therapy for topical treatment of recessive dystrophic epidermolysis bullosa.
Xianqing Wang, Xi Wang, Yinghao Li, Sigen A, Bei Qiu

Mol Ther Methods Clin Dev· December 2023

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Chitosan-Based Hydrogels for Infected Wound Treatment.
Xiaoyu Wang, Rijian Song, Melissa Johnson, Sigen A, Pingping Shen

Macromol Biosci· September 2023

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Guanidyl-Rich Poly(β Amino Ester)s for Universal Functional Cytosolic Protein Delivery and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Cas9 Ribonucleoprotein Based Gene Editing.
Xianqing Wang, Yinghao Li, Xi Wang, Dario M Sandoval, Zhonglei He

ACS Nano· September 2023

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Multidomain interventions for non-pharmacological enhancement (MINE) program in Chinese older adults with mild cognitive impairment: a multicenter randomized controlled trial protocol.
Xiaochu Wu, Tianyao Zhang, Yanhao Tu, Xueling Deng, A Sigen

BMC Neurol· September 2023

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Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD).
Yinghao Li, Zhonglei He, Sigen A, Xianqing Wang, Zishan Li

ACS Appl Mater Interfaces· August 2023

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3D Macrocyclic Structure Boosted Gene Delivery: Multi-Cyclic Poly(β-Amino Ester)s from Step Growth Polymerization.
Yinghao Li, Xianqing Wang, Zhonglei He, Melissa Johnson, Sigen A

J Am Chem Soc· August 2023

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Branch Unit Distribution Matters for Gene Delivery.
Yinghao Li, Zhonglei He, Xianqing Wang, Zishan Li, Melissa Johnson

ACS Macro Lett· June 2023

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A New Optimization Strategy of Highly Branched Poly(β-Amino Ester) for Enhanced Gene Delivery: Removal of Small Molecular Weight Components.
Yinghao Li, Xianqing Wang, Zhonglei He, Zishan Li, Melissa Johnson

Polymers (Basel)· March 2023

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A Novel Hydrophilic, Antibacterial Chitosan-Based Coating Prepared by Ultrasonic Atomization Assisted LbL Assembly Technique.
Xiaoyu Wang, Yuyang Zhou, Melissa Johnson, Cameron Milne, Sigen A

J Funct Biomater· January 2023

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Hyperbranched Poly(β-amino ester)s (HPAEs) Structure Optimisation for Enhanced Gene Delivery: Non-Ideal Termination Elimination.
Yinghao Li, Zhonglei He, Jing Lyu, Xianqing Wang, Bei Qiu

Nanomaterials (Basel)· November 2022

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-crosslinked hydrogel-induced experimental glaucoma model with persistent ocular hypertension and neurodegeneration.
Jicheng Lin, Jingfei Xue, Qian Xu, Zhe Liu, Chunyu Zhao

Biomater Sci· August 2022

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Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.
Jonathan O'Keeffe Ahern, Irene Lara-Sáez, Dezhong Zhou, Rodolfo Murillas, Jose Bonafont

Gene Ther· April 2022

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Value of glycogen synthase 2 in intrahepatic cholangiocarcinoma prognosis assessment and its influence on the activity of cancer cells.
Sigen A, Huijun Wu, Xiaodong Wang, Xidong Wang, Jiarui Yang

Bioengineered· December 2021

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Forming Hyperbranched PEG-Thiolated Hyaluronic Acid Hydrogels With Honey-Mimetic Antibacterial Properties.
Jeddah Marie Vasquez, Ayesha Idrees, Irene Carmagnola, Aa Sigen, Sean McMahon

Front Bioeng Biotechnol· November 2021

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Development of Minicircle Vectors Encoding COL7A1 Gene with Human Promoters for Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa.
Xianqing Wang, Fatma Alshehri, Darío Manzanares, Yinghao Li, Zhonglei He

Int J Mol Sci· November 2021

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An Injectable Chitosan-Based Self-Healable Hydrogel System as an Antibacterial Wound Dressing.
Xiaoyu Wang, Rijian Song, Melissa Johnson, Sigen A, Zhonglei He

Materials (Basel)· October 2021

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