Publications by authors named "Silke Frey"

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Care pathways combining digital therapeutics and conventional care for musculoskeletal disorders: State sequence analyses of 4-year claims data.
Silke Frey, Annika Schmitz, Udo Schneider, Linda Kerkemeyer, Birgitta Weltermann

Digit Health· October 2025

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Loss of myeloperoxidase aggravates skin and joint inflammation in the mannan-induced psoriatic arthritis mouse model.
Mark Ringer, Antonio Maccataio, Rico Zapf, Anastasia Gaculenko, Susanne Adam, Silke Frey

J Leukoc Biol· September 2025

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Digital Health Applications (DiGA) for Treating Depression and Generalized Anxiety Disorder: Protocol for a Systematic Health App Review and Systematic Review of Published Evidence.
Annika Schmitz, Lucas Kueppers, Jacob Klein, Silke Frey, Arian Karimzadeh

JMIR Res Protoc· July 2025

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Combined Use of Digital and Analog Physical Therapy in Patients With Musculoskeletal Disorders and Indicators of Chronicity: German Claims Data Analysis.
Silke Frey, Annika Schmitz, Udo Schneider, Linda Kerkemeyer, Birgitta Weltermann

JMIR Mhealth Uhealth· June 2025

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Regional socioeconomic characteristics and density of general practitioners in Germany: A nationwide cross-sectional and longitudinal spatial analysis.
Benjamin Aretz, Silke Frey, Birgitta Weltermann

Public Health· November 2024

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Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.
Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Silke Frey

Nat Commun· February 2024

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Acceptance of digital health applications in non-pharmacological therapies in German statutory healthcare system: Results of an online survey.
Silke Frey, Linda Kerkemeyer

Digit Health· December 2022

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The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B Wild, Silke Frey

Front Immunol· August 2022

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Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis.
Merlijn H Kaaij, Jasper Rip, Kim C M Jeucken, Yik Y Kan, Charlotte C N van Rooijen, Silke Frey

J Immunol· November 2021

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The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Benjamin Frey, Silke Frey

Immunity· May 2021

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Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia.
Jutta Ries, Abbas Agaimy, Falk Wehrhan, Christoph Baran, Stella Bolze, Silke Frey

Biomedicines· February 2021

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Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo.
Manuel Weber, Andi Homm, Stefan Müller, Silke Frey, Kerstin Amann

Int J Mol Sci· January 2021

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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
Stefan Haskamp, Heiko Bruns, Madelaine Hahn, Markus Hoffmann, Anne Gregor, Benjamin Frey, Silke Frey

Am J Hum Genet· September 2020

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Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis.
Silke Frey, Heinrich Sticht, Dagmar Wilsmann-Theis, Anne Gerschütz, Katharina Wolf, Benjamin Frey

J Invest Dermatol· July 2020

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JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.
Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T Andes, Carina Scholtysek, Silke Frey

Sci Transl Med· February 2020

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Structural insights into heme binding to IL-36α proinflammatory cytokine.
Amelie Wißbrock, Nishit B Goradia, Amit Kumar, Ajay Abisheck Paul George, Toni Kühl, Silke Frey

Sci Rep· November 2019

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Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.
Verena Schmitt, Madelaine Hahn, Verena Kästele, Olga Wagner, Maximilian Wiendl, Silke Frey

Eur J Immunol· December 2017

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Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction.
Olga Kurow, Benjamin Frey, Louis Schuster, Verena Schmitt, Susanne Adam, Silke Frey

Front Immunol· June 2017

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The novel interleukin-1 cytokine family members in inflammatory diseases.
Madelaine Hahn, Silke Frey, Axel J Hueber

Curr Opin Rheumatol· March 2017

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Blockade of IL-36 receptor signaling does not prevent from TNF-induced arthritis.
Anja Derer, Bettina Groetsch, Ulrike Harre, Christina Böhm, Jennifer Towne, Silke Frey

PLoS One· April 2015

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The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium.
Silke Frey, Anja Derer, Maria-Elena Messbacher, Dominique L P Baeten, Serena Bugatti

Ann Rheum Dis· September 2013

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Toll-like receptor 2 is required for autoantibody production and development of renal disease in pristane-induced lupus.
Vilma Urbonaviciute, Charlotte Starke, Wiebke Pirschel, Sandy Pohle, Silke Frey

Arthritis Rheum· June 2013

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Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency.
Barbara Lödermann, Roland Wunderlich, Silke Frey, Christine Schorn, Sonja Stangl, Benjamin Frey

Int J Radiat Biol· October 2012

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Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.
Eva Gückel, Silke Frey, Mario M Zaiss, Georg Schett, Sankar Ghosh

PLoS One· October 2011

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High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice.
Charlotte Starke, Silke Frey, Ute Wellmann, Vilma Urbonaviciute, Martin Herrmann

Eur J Immunol· July 2011

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