Publications by authors named "Jennifer Towne"

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Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake.
Kelly L Damm-Ganamet, Clara Moon, Alan D Wickenden, Mark Tichenor, Yunhui Ge, Jennifer E Towne

J Clin Invest· November 2025

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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Anne M Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Jennifer Towne

Sci Rep· July 2024

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Retraction: The PAR2 signal peptide prevents premature receptor cleavage and activation.
Belinda Liu, Grace Lee, Jiejun Wu, Janise Deming, Chester Kuei, Jennifer Towne

PLoS One· June 2024

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Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.
John L Johnson, Davit Sargsyan, Eric M Neiman, Amy Hart, Aleksandar Stojmirovic, Jennifer E Towne

JCI Insight· February 2024

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Holger Babbe, Thomas B Sundberg, Mark Tichenor, Mark Seierstad, Genesis Bacani, Jennifer E Towne

Proc Natl Acad Sci U S A· January 2024

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Aaron A Thompson, Michael B Harbut, Pei-Pei Kung, Nathan K Karpowich, Jeffrey D Branson, Jennifer E Towne

Proc Natl Acad Sci U S A· May 2023

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Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions.
Kacey L Sachen, Carrie N Arnold Greving, Jennifer E Towne

Cytokine· August 2022

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QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Kwontae You, Lingfei Wang, Chih-Hung Chou, Kai Liu, Toru Nakata, Jennifer E Towne

Science· January 2021

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Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.
Jeremy A Goettel, Daniel Kotlarz, Rohini Emani, James B Canavan, Liza Konnikova, Jennifer E Towne

Cell Mol Gastroenterol Hepatol· July 2020

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The PAR2 signal peptide prevents premature receptor cleavage and activation.
Belinda Liu, Grace Lee, Jiejun Wu, Janise Deming, Chester Kuei, Jennifer Towne

PLoS One· April 2020

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The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis.
Carl L Manthey, Beverley A Moore, Yanqing Chen, Matthew J Loza, Xiang Yao, Jennifer E Towne

PLoS One· March 2020

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Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome.
Elodie Bal, Ai Ching Lim, Min Shen, Jason Douangpanya, Marine Madrange, Jennifer E Towne

Exp Dermatol· October 2019

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A Role for IL-12 in IBD after All?
Carrie N Arnold Greving, Jennifer E Towne

Immunity· August 2019

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Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Theresa T Pizarro, Thaddeus S Stappenbeck, Florian Rieder, Michael J Rosen, Jean-Frédéric Colombel, Jennifer Towne

Inflamm Bowel Dis· May 2019

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Publisher Correction: Get the IL-17F outta here!
Aisling O'Hara Hall, Jennifer E Towne, Scott E Plevy

Nat Immunol· March 2019

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Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease.
Kelli L VanDussen, Aleksandar Stojmirović, Katherine Li, Ta-Chiang Liu, Patrick K Kimes, Jennifer E Towne

Gastroenterology· September 2018

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Get the IL-17F outta here!
Aisling O'Hara Hall, Jennifer E Towne, Scott E Plevy

Nat Immunol· July 2018

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Regulation and function of interleukin-36 cytokines.
Esen Yonca Bassoy, Jennifer E Towne, Cem Gabay

Immunol Rev· January 2018

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Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses.
Warren N D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Jennifer E Towne

PLoS One· September 2017

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Effect of IL-17 receptor A blockade with brodalumab in inflammatory diseases.
Ajay Nirula, Jon Nilsen, Paul Klekotka, Greg Kricorian, Ngozi Erondu, Jennifer E Towne

Rheumatology (Oxford)· December 2016

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Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines.
Damien Dietrich, Praxedis Martin, Vincent Flacher, Yu Sun, David Jarrossay, Jennifer Towne

Cytokine· August 2016

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Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.
Oscar Medina-Contreras, Akihito Harusato, Hikaru Nishio, Kyle L Flannigan, Vu Ngo, Jennifer E Towne

J Immunol· January 2016

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Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Joseph R Maxwell, Yu Zhang, William A Brown, Carole L Smith, Fergus R Byrne, Jennifer E Towne

Immunity· October 2015

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Blockade of IL-36 receptor signaling does not prevent from TNF-induced arthritis.
Anja Derer, Bettina Groetsch, Ulrike Harre, Christina Böhm, Jennifer Towne

PLoS One· April 2015

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Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.
Cem Gabay, Jennifer E Towne

J Leukoc Biol· April 2015

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