Publications by authors named "Silvia A Mandel"

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Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra.
Edna Grünblatt, Josefine Ruder, Camelia Maria Monoranu, Peter Riederer, Moussa Bh Youdim, Silvia A Mandel

Neurotox Res· April 2018

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DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline.
Dorit Trudler, Orly Weinreb, Silvia A Mandel, Moussa B H Youdim, Dan Frenkel

J Neurochem· May 2014

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Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism.
Yulia Pollak, Danit Mechlovich, Tamar Amit, Orit Bar-Am, Irena Manov, Silvia A Mandel

J Neural Transm (Vienna)· January 2013

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In the rush for green gold: Can green tea delay age-progressive brain neurodegeneration?
Silvia A Mandel, Moussa B H Youdim

Recent Pat CNS Drug Discov· December 2012

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From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease.
Hailin Zheng, Tamar Amit, Orit Bar-Am, Mati Fridkin, Moussa B H Youdim, Silvia A Mandel

J Alzheimers Dis· September 2012

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Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease.
Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdim

Neurodegener Dis· August 2012

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Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease.
Orly Weinreb, Tamar Amit, Peter Riederer, Moussa B H Youdim, Silvia A Mandel

Int Rev Neurobiol· July 2012

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A molecular signature in blood identifies early Parkinson's disease.
Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonucelli, Roberto Ceravolo, Silvia A Mandel

Mol Neurodegener· May 2012

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Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease.
Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdim

Parkinsonism Relat Disord· January 2012

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Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols.
Silvia A Mandel, Orly Weinreb, Tamar Amit, Moussa B H Youdim

Front Biosci (Schol Ed)· January 2012

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Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases.
Silvia A Mandel, Tamar Amit, Orly Weinreb, Moussa B H Youdim

J Alzheimers Dis· November 2011

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Low dosage of rasagiline and epigallocatechin gallate synergistically restored the nigrostriatal axis in MPTP-induced parkinsonism.
Lydia Reznichenko, Limor Kalfon, Tamar Amit, Moussa B H Youdim, Silvia A Mandel

Neurodegener Dis· January 2011

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.
Bin Zheng, Zhixiang Liao, Joseph J Locascio, Kristen A Lesniak, Sarah S Roderick, Silvia A Mandel

Sci Transl Med· October 2010

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Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease.
Tali Fishman-Jacob, Moussa B H Youdim, Silvia A Mandel

Neurodegener Dis· July 2010

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The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage.
Danit Mechlovich, Tamar Amit, Silvia A Mandel, Orit Bar-Am, Konstantin Bloch

J Pharmacol Exp Ther· June 2010

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Biomarkers for prediction and targeted prevention of Alzheimer's and Parkinson's diseases: evaluation of drug clinical efficacy.
Silvia A Mandel, Micaela Morelli, Ilan Halperin, Amos D Korczyn

EPMA J· June 2010

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Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A.
Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdim

Parkinsonism Relat Disord· December 2009

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A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A.
Tali Fishman-Jacob, Lydia Reznichenko, Moussa B H Youdim, Silvia A Mandel

J Biol Chem· November 2009

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Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD.
Silvia A Mandel, Tali Fishman, Moussa B H Youdim

Parkinsonism Relat Disord· April 2009

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Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.
Silvia A Mandel, Tamar Amit, Orly Weinreb, Lydia Reznichenko, Moussa B H Youdim

CNS Neurosci Ther· February 2009

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Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases.
Ilan Halperin, Micaela Morelli, Amos D Korczyn, Moussa B H Youdim, Silvia A Mandel

Neurotherapeutics· January 2009

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Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).
Silvia A Mandel, Tamar Amit, Limor Kalfon, Lydia Reznichenko, Orly Weinreb

J Alzheimers Dis· October 2008

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Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins.
Silvia A Mandel, Tamar Amit, Limor Kalfon, Lydia Reznichenko, Moussa B H Youdim

J Nutr· August 2008

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Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway.
Silvia A Mandel, Yotam Sagi, Tamar Amit

Neurochem Res· October 2007

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Green tea polyphenol (-) -epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection.
Limor Kalfon, Moussa B H Youdim, Silvia A Mandel

J Neurochem· February 2007

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