Publications by authors named "Silvia Coma"

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A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition.
Jesse D Riordan, Teagan A Nathanson, Afshin Varzavand, Adeline A Hawkins, Rebekah M Peplinski, Silvia Coma

Oncogene· December 2025

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Preclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor.
Cem Demirkiran, Stefania Bellone, Victoria M Ettorre, Miranda Mansolf, Tobias Max Philipp Hartwich, Silvia Coma

Int J Mol Sci· September 2025

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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma.
Simone Lubrano, Rodolfo Daniel Cervantes-Villagrana, Farhoud Faraji, Sydney Ramirez, Kuniaki Sato, Silvia Coma

Cancer Cell· March 2025

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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases.
Jared Almazan, Tursun Turapov, David A Kircher, Karly A Stanley, Katie Culver, Silvia Coma

Cell Rep Med· February 2025

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A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition.
Jesse D Riordan, Teagan A Nathanson, Afshin Varzavand, Adeline A Hawkins, Rebekah M Peplinski, Silvia Coma

bioRxiv· December 2024

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The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Silvia Coma

Mol Cancer Ther· October 2024

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Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy.
Xiuting Liu, John M Baer, Meredith L Stone, Brett L Knolhoff, Graham D Hogg, Silvia Coma

Sci Transl Med· October 2024

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Preclinical evaluation of avutometinib and defactinib in high-grade endometrioid endometrial cancer.
Tobias Max Philipp Hartwich, Miranda Mansolf, Cem Demirkiran, Michelle Greenman, Stefania Bellone, Silvia Coma

Cancer Med· September 2024

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Preclinical in vitro and in vivo activity of the RAF/MEK clamp avutometinib in combination with FAK inhibition in uterine carcinosarcomas.
Cem Demirkiran, Michelle Greenman, Stefania Bellone, Blair McNamara, Tobias Max Philipp Hartwich, Silvia Coma

Gynecol Oncol· August 2024

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Preclinical efficacy of RAF/MEK clamp avutometinib in combination with FAK inhibition in low grade serous ovarian cancer.
Blair McNamara, Cem Demirkiran, Tobias Max Philipp Hartwich, Stefania Bellone, Diego Manavella, Silvia Coma

Gynecol Oncol· April 2024

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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Nadia Arang, Simone Lubrano, Michele Ceribelli, Damiano C Rigiracciolo, Robert Saddawi-Konefka, Silvia Coma

Cell Rep Med· November 2023

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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib.
Kathleen J Till, Mariah Abdullah, Tahera Alnassfan, Gallardo Zapata Janet, Thomas Marks, Silvia Coma

Sci Rep· March 2023

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Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
John Blazeck, Christos S Karamitros, Kyle Ford, Catrina Somody, Ahlam Qerqez, Silvia Coma

Nat Catal· October 2022

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Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression.
Karen McGovern, Alfredo C Castro, Jill Cavanaugh, Silvia Coma, Meghan Walsh

Mol Cancer Ther· August 2022

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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
Christopher Ronald Funk, Shuhua Wang, Kevin Z Chen, Alexandra Waller, Aditi Sharma, Silvia Coma

Blood· January 2022

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Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for -Driven Uveal Melanoma.
Justine S Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Simone Lubrano, Silvia Coma

Clin Cancer Res· August 2021

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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for -Driven Uveal Melanoma.
Justine S Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Frederico Gomes, Silvia Coma

Clin Cancer Res· June 2021

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Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models.
Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn

Blood· June 2021

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Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Todd A Triplett, Kendra C Garrison, Nicholas Marshall, Moses Donkor, John Blazeck, Silvia Coma

Nat Biotechnol· September 2018

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Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.
R Grant Rowe, Leo D Wang, Silvia Coma, Areum Han, Ronald Mathieu

J Exp Med· July 2016

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Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
Hironao Nakayama, Sarah Bruneau, Nora Kochupurakkal, Silvia Coma, David M Briscoe

Sci Rep· July 2015

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AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.
Elisa Boscolo, Silvia Coma, Valerie L Luks, Arin K Greene, Michael Klagsbrun

Angiogenesis· April 2015

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Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody.
Jose Luis Hernández, Laura Padilla, Sheila Dakhel, Toni Coll, Rosa Hervas, Silvia Coma

PLoS One· April 2014

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GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.
Silvia Coma, Marc Allard-Ratick, Tomoshige Akino, Laurens A van Meeteren, Akiko Mammoto

Angiogenesis· October 2013

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Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Akio Shimizu, Hironao Nakayama, Priscilla Wang, Courtney König, Tomoshige Akino, Silvia Coma

J Biol Chem· January 2013

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