Publications by authors named "Simon Bushell"

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Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, Gamma Chi, Jesper S Hansen, Simon R Bushell

Nat Commun· June 2024

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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Simon R Bushell

Nat Commun· May 2024

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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.
Marie-Hélène Larraufie, Xiaolin Gao, Xiaobo Xia, Patrick J Devine, Joerg Kallen, Simon M Bushell

Cell Chem Biol· September 2021

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Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay.
Jonathan D Mortison, Ivan Cornella-Taracido, Gireedhar Venkatchalam, Anthony W Partridge, Nirodhini Siriwardana, Simon M Bushell

ACS Med Chem Lett· August 2021

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The structural basis of fatty acid elongation by the ELOVL elongases.
Laiyin Nie, Tomas C Pascoa, Ashley C W Pike, Simon R Bushell, Andrew Quigley

Nat Struct Mol Biol· June 2021

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Systematic Chemogenetic Library Assembly.
Stephen M Canham, Yuan Wang, Allen Cornett, Douglas S Auld, Daniel K Baeschlin, Simon M Bushell

Cell Chem Biol· September 2020

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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Simon R Bushell, Ashley C W Pike, Maria E Falzone, Nils J G Rorsman, Chau M Ta

Nat Commun· September 2019

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Discovery of a ZIP7 inhibitor from a Notch pathway screen.
Erin Nolin, Sara Gans, Luis Llamas, Somnath Bandyopadhyay, Scott M Brittain, Simon M Bushell

Nat Chem Biol· February 2019

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Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Yin Yao Dong, Hua Wang, Ashley C W Pike, Stephen A Cochrane, Sadra Hamedzadeh, Simon R Bushell

Cell· November 2018

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Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Simon M Bushell

PLoS One· May 2016

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Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli.
Simon R Bushell, Iain L Mainprize, Martin A Wear, Hubing Lou, Chris Whitfield

Structure· May 2013

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Discovery of LFF571: an investigational agent for Clostridium difficile infection.
Matthew J LaMarche, Jennifer A Leeds, Adam Amaral, Jason T Brewer, Simon M Bushell

J Med Chem· March 2012

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Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli.
Hubing Lou, Min Chen, Susan S Black, Simon R Bushell, Matteo Ceccarelli

PLoS One· February 2012

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Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
Matthew J LaMarche, Jennifer A Leeds, Kerri Amaral, Jason T Brewer, Simon M Bushell

J Med Chem· December 2011

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Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.
Qing-Yin Wang, Simon Bushell, Min Qing, Hao Ying Xu, Aurelio Bonavia

J Virol· July 2011

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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV).
Aurelio Bonavia, Michael Franti, Erin Pusateri Keaney, Kelli Kuhen, Mohindra Seepersaud, Simon M Bushell

Proc Natl Acad Sci U S A· April 2011

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Crystallization and preliminary diffraction analysis of Wzi, a member of the capsule export and assembly pathway in Escherichia coli.
Simon R Bushell, Hubing Lou, Gregor D Wallat, Konstantinos Beis, Chris Whitfield

Acta Crystallogr Sect F Struct Biol Cryst Commun· December 2010

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Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis.
Julian P Vivian, Jessica Scoullar, Kieran Rimmer, Simon R Bushell, Travis Beddoe

J Mol Biol· December 2009

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Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Travis Beddoe, Zhenjun Chen, Craig S Clements, Lauren K Ely, Simon R Bushell

Immunity· June 2009

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Progress toward a rationally designed, chemically powered rotary molecular motor.
T Ross Kelly, Xiaolu Cai, Fehmi Damkaci, Sreeletha B Panicker, Bin Tu, Simon M Bushell

J Am Chem Soc· January 2007

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Tracking the unfolding pathway of a multirepeat protein via tryptophan scanning: evidence of localized instability in the mitochondrial import receptor Tom70.
Simon R Bushell, Stephen P Bottomley, Jamie Rossjohn, Travis Beddoe

J Biol Chem· August 2006

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Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor.
John W Huffman, Simon M Bushell, Sudhir N Joshi, Jenny L Wiley, Billy R Martin

Bioorg Med Chem· January 2006

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Total synthesis of nigellicine and nigeglanine hydrobromide.
Eric L Elliott, Simon M Bushell, Marta Cavero, Brian Tolan, T Ross Kelly

Org Lett· June 2005

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Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
John W Huffman, Gulay Zengin, Ming-Jung Wu, Jianzhong Lu, George Hynd, Kristen Bushell, Simon Bushell

Bioorg Med Chem· January 2005

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A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway.
Travis Beddoe, Simon R Bushell, Matthew A Perugini, Trevor Lithgow, Terrence D Mulhern

J Biol Chem· November 2004

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