Publications by authors named "Simon Leedham"

Claim this Profile
C
Comparison between germline and somatic loss-of-function mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis.
Claire Palles, Luke Freeman-Mills, Edward Arbe-Barnes, Nathalie Feeley, Laura Chegwidden, Simon J Leedham

Gut· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Defining the mucosal ecosystem: epithelial-mesenchymal interdependence in gastrointestinal health and disease.
Frances J England, Manqiang Lin, Michael Sigal, Simon J Leedham

Nat Rev Gastroenterol Hepatol· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance.
Mark White, Megan L Mills, Laura M Millett, Kathryn Gilroy, Yourae Hong, Simon Leedham

Nature· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Lauren Murphy, Jeanne Inchauspé, Giampiero Valenzano, Pamela Holland, Nikolaos Sousos, Simon Leedham

Science· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome.
Konstantin Bräutigam, Philipp Zens, Stefan Reinhard, Jessica L Rohrbach, Simon J Leedham

BMC Cancer· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.
Eoghan J Mulholland, Hayley L Belnoue-Davis, Gabriel N Valbuena, Nuray Gunduz, Amelia Ligeza, Simon J Leedham

Nat Commun· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.
Ibrahim Al Bakir, Kit Curtius, George D Cresswell, Heather E Grant, Nadia Nasreddin, Simon J Leedham

Gut· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease.
James Edward East, Morris Gordon, Gaurav Bhaskar Nigam, Vassiliki Sinopoulou, Adrian C Bateman, Simon John Leedham

Gut· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Study protocol for putting the 'Person' in the PiCTuRE: an exploratory sequential mixed methods-based design, exploring how precision medicine is implemented and experienced by people living with a primary tumour of the craniospinal axis.
Gerard Mawhinney, Helen Higham, Simon Leedham, Olaf Ansorge

BMC Cancer· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis.
Lydia A Schoenpflug, Aikaterini Chatzipli, Korsuk Sirinukunwattana, Susan Richman, Andrew Blake, Simon J Leedham

J Pathol· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD.
Rodrigo V Motta, Vipin Gupta, Karen Hartery, Paul Bassett, Simon J Leedham

Endosc Int Open· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Update from 2010 (standard operating procedure): protocol for the 2024 British Society of Gastroenterology Guidelines on colorectal surveillance in inflammatory bowel disease.
Morris Gordon, Gaurav Bhaskar Nigam, Vassiliki Sinopoulou, Ibrahim Al Bakir, Adrian C Bateman, Simon Leedham

BMJ Open Gastroenterol· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors.
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, Simon Leedham

EBioMedicine· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K Nambiar, Simon J Leedham

J Clin Invest· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.
Umair Mahmood, Andrew Blake, Sanjay Rathee, Leslie Samuel, Graeme Murray, Simon J Leedham

Cancer Res Commun· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis.
Ibrahim Al Bakir, Kit Curtius, George D Cresswell, Heather E Grant, Nadia Nasreddin, Simon J Leedham

medRxiv· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Simon J Leedham

Nat Genet· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular mechanism of BMP signal control by Twisted gastrulation.
Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Simon J Leedham

Nat Commun· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Poor Diagnostic Reproducibility in the Identification of Nonconventional Dysplasia in Colitis Impacts the Application of Histologic Stratification Tools.
Nadia Nasreddin, Marnix Jansen, Maurice B Loughrey, Lai Mun Wang, Viktor H Koelzer, Simon J Leedham

Mod Pathol· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Simon J Leedham

Nat Genet· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Extended correlation functions for spatial analysis of multiplex imaging data.
Joshua A Bull, Eoghan J Mulholland, Simon J Leedham, Helen M Byrne

Biol Imaging· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K Nambiar, Simon J Leedham

J Clin Invest· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Î
β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer.
Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor, Anastasia Georgakopoulou, Simon J Leedham

Cancer Immunol Res· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Virtual alignment of pathology image series for multi-gigapixel whole slide images.
Chandler D Gatenbee, Ann-Marie Baker, Sandhya Prabhakaran, Ottilie Swinyard, Robbert J C Slebos, Simon Leedham

Nat Commun· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Dustin J Flanagan, Raheleh Amirkhah, David F Vincent, Nuray Gunduz, Pauline Gentaz, Simon J Leedham

Nat Commun· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis