Publications by authors named "Simon MacDonald"

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Clinical Applications of Point-of-Care and Diagnostic Transcranial Doppler in the Pediatric Acute Care Setting: A Scoping Review.
Virginie Plante, Nicole O'Brien, Simon MacDonald, Laurence Tabone, Camille Jutras

Neurocrit Care· August 2025

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Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure.
Ralph Ml Neijenhuis, Madelien V Regeer, Niki L Walker, Bart Ja Mertens, Amanda Hunter, Simon T MacDonald

Open Heart· July 2025

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Core Modifications of GSK3335103 toward Orally Bioavailable αβ Inhibitors with Improved Synthetic Tractability.
Heather F Hryczanek, John Barrett, Tim N Barrett, Glenn A Burley, Rosa E Cookson, Simon J F Macdonald

J Med Chem· November 2024

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Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αβ Integrin Inhibitors.
Panayiotis A Procopiou, John Barrett, Matthew H J Crawford, Richard J D Hatley, Ashley P Hancock, Simon J F Macdonald

J Med Chem· October 2024

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Two months outcomes following delirium in the pediatric intensive care unit.
Celine Thibault, Geneviève Du Pont-Thibodeau, Simon MacDonald, Camille Jutras, Marie-Élaine Metras

Eur J Pediatr· June 2024

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Effect of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Congenital Heart Disease.
Ralph M L Neijenhuis, Simon T MacDonald, Filip Zemrak, Bart J A Mertens, Anna Dinsdale

J Am Coll Cardiol· April 2024

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Outcomes of patients supported by mechanical ventilation and their families two months after discharge from pediatric intensive care unit.
Simon MacDonald, Geneviève Du Pont-Thibodeau, Celine Thibault, Camille Jutras, Nadia Roumeliotis

Front Pediatr· January 2024

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Percutaneous heart valves demonstrating long-term durability: A case series of Melody valves in the pulmonary position lasting up to 19 years.
Simon T MacDonald, Amit Bhan, Sachin Khambadkone, Michael Mullen

Catheter Cardiovasc Interv· January 2023

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Medicinal chemistry in big pharma has a gender diversity problem.
Simon Jf Macdonald

Future Med Chem· October 2022

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Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.
Jennifer M Clark, Fernando Salgado-Polo, Simon J F Macdonald, Tim N Barrett, Anastassis Perrakis

J Med Chem· April 2022

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How Diverse Is Medicinal Chemistry? Insights into Race, Ethnicity, Origin, Gender, and Geography.
Richard J D Hatley, Steve P McLachlan, Kathleen Baster, Lucy C Gelder, Simon J F Macdonald

J Med Chem· January 2022

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Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease.
Alex L Wilkinson, Alison E John, John W Barrett, E Gower, Valerie S Morrison, Simon J F Macdonald

Eur J Pharmacol· December 2021

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Wide variation in surgical techniques to repair incisional hernias: a survey of practice patterns among general surgeons.
Simon MacDonald, Paul M Johnson

BMC Surg· May 2021

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Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors.
Richard J D Hatley, Panayiotis A Procopiou, Steven P McLachlan, Laura E Westendorf, Nicholas A Meanwell, Simon J F Macdonald

J Med Chem· December 2020

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Molecular Simulation of αvβ6 Integrin Inhibitors.
Ellen E Guest, Steven A Oatley, Simon J F Macdonald, Jonathan D Hirst

J Chem Inf Model· November 2020

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Partial anomalous pulmonary venous drainage in patients presenting with suspected pulmonary hypertension: A series of 90 patients from the ASPIRE registry.
Robert A Lewis, Catherine G Billings, Aidan Bolger, Sarah Bowater, Athanasios Charalampopoulos, Simon MacDonald

Respirology· October 2020

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Unusual arm collateralisation post classical Blalock-Taussig shunt revealed post haemoptysis.
Sanjay S Bhandari, Simon T MacDonald

Eur Heart J Case Rep· October 2020

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Iridium-catalysed C-H borylation of β-aryl-aminopropionic acids.
Henry Robinson, Joe Stillibrand, Klemensas Simelis, Simon J F Macdonald, Andrew Nortcliffe

Org Biomol Chem· September 2020

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.
Alison E John, Rebecca H Graves, K Tao Pun, Giovanni Vitulli, Ellen J Forty, Simon J F Macdonald

Nat Commun· September 2020

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Late-Stage Functionalization by Chan-Lam Amination: Rapid Access to Potent and Selective Integrin Inhibitors.
Henry Robinson, Steven A Oatley, James E Rowedder, Pawel Slade, Simon J F Macdonald

Chemistry· June 2020

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Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery.
Simon J F Macdonald, Richard J D Hatley

Drug Discov Today· March 2020

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Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of -Methylation for PI3Kδ Activity.
Lydia Barnes, Hollie Blaber, David T K Brooks, Lewis Byers, Daniel Buckley, Simon J F Macdonald

J Med Chem· November 2019

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Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
Niall A Anderson, Sebastien Campos, Sharon Butler, Royston C B Copley, Ian Duncan, Simon J F Macdonald

J Med Chem· October 2019

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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αβ Integrin Inhibitor-(3)-3-(3-(3,5-Dimethyl-1-pyrazol-1-yl)phenyl)-4-((1 and 1,3)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
Tim N Barrett, Jonathan A Taylor, Daniel Barker, Panayiotis A Procopiou, James D F Thompson, Simon J F Macdonald

J Med Chem· August 2019

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The Design of Potent, Selective and Drug-Like RGD αvβ1 Small-Molecule Inhibitors Derived from non-RGD α4β1 Antagonists.
Richard J D Hatley, Tim N Barrett, Robert J Slack, Morag E Watson, Daniel J Baillache, Simon J F Macdonald

ChemMedChem· July 2019

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