Publications by authors named "Simon Tate"

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Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations.
Robert R Edwards, Kristin L Schreiber, Robert H Dworkin, Dennis C Turk, Ralf Baron, Simon Tate

J Pain· February 2023

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Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia.
David R Witty, Giuseppe Alvaro, Dominique Derjean, Gerard M P Giblin, Kevin Gunn, Simon Tate

ACS Med Chem Lett· September 2020

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Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia.
Mona Kotecha, William P Cheshire, Helen Finnigan, Kathryn Giblin, Himanshu Naik, Simon Tate

J Pain Res· July 2020

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Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers.
Joi Dunbar, Mark Versavel, Yuan Zhao, Simon Tate, Valerie Morisset

Clin Pharmacol Drug Dev· January 2020

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Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience.
Joanna M Zakrzewska, Joanne Palmer, Lars Bendtsen, Giulia Di Stefano, Dominik A Ettlin, Simon Tate

Trials· December 2018

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Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
Joanna M Zakrzewska, Joanne Palmer, Valerie Morisset, Gerard Mp Giblin, Mark Obermann, Simon Tate

Lancet Neurol· April 2017

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A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy.
Joachim Scholz, James P Rathmell, William S David, David A Chad, Alithia C Broderick, Simon N Tate

Pain· October 2016

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A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia.
Brian S Tanaka, Peng Zhao, Fadia B Dib-Hajj, Valerie Morisset, Simon Tate

Mol Med· September 2016

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Multiple mechanisms have been tested in pain--how can we improve the chances of success?
Ann G Hayes, Lars Arendt-Nielsen, Simon Tate

Curr Opin Pharmacol· February 2014

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Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia.
Joanna M Zakrzewska, Joanne Palmer, Dominik A Ettlin, Mark Obermann, Gerard M P Giblin, Simon Tate

Trials· November 2013

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Nav(1.8)igating the maze of sensory function.
Simon Tate, Dominique Derjean, François Rugiero

Pain· October 2012

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Transient receptor potential channels: targeting pain at the source.
Ardem Patapoutian, Simon Tate, Clifford J Woolf

Nat Rev Drug Discov· January 2009

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The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.
Fumimasa Amaya, Haibin Wang, Michael Costigan, Andrew J Allchorne, Jon P Hatcher, Simon Tate

J Neurosci· December 2006

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Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding.
Holger Scheib, Iain McLay, Nicolas Guex, Jeff J Clare, Frank E Blaney, Simon N Tate

J Mol Model· September 2006

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Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
Marie Pertin, Ru-Rong Ji, Temugin Berta, Andrew J Powell, Laurie Karchewski, Simon N Tate

J Neurosci· November 2005

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Expression of the sodium channel beta3 subunit in injured human sensory neurons.
Maria A Casula, Paul Facer, Andrew J Powell, Ian J Kinghorn, Christopher Plumpton, Simon N Tate

Neuroreport· July 2004

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Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum.
Mao Xiang Chen, Shelby A Gorman, Bill Benson, Kuljit Singh, J Paul Hieble, Simon N Tate

Naunyn Schmiedebergs Arch Pharmacol· June 2004

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Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23.
Victoria H John, Martin J Main, Andrew J Powell, Zoe M Gladwell, Caroline Hick, Simon Tate

Neuropharmacology· March 2004

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Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats.
Richard E Coggeshall, Simon Tate, Susan M Carlton

Neurosci Lett· January 2004

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High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
Michael Costigan, Tarek A Samad, Andrew Allchorne, Christopher Lanoue, Simon Tate

Mol Cell Neurosci· September 2003

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Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.
Steven J Arnold, Paul Facer, Yiangos Yiangou, Mark X Chen, Christopher Plumpton, Simon N Tate

Neuroreport· February 2003

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The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.
Isabelle Decosterd, Ru-Rong Ji, Salahadin Abdi, Simon Tate, Clifford J Woolf

Pain· April 2002

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Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Andrew T Bucknill, Kevin Coward, Christopher Plumpton, Simon Tate, Chas Bountra

Spine (Phila Pa 1976)· January 2002

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