Publications by authors named "Simon Teague"

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iBCS: 4. Application of the Inhalation Biopharmaceutics Classification System to the Development of Orally Inhaled Drug Products.
Ben Forbes, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Simon Teague

Mol Pharm· April 2025

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iBCS: 3. A Biopharmaceutics Classification System for Orally Inhaled Drug Products.
Jayne E Hastedt, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Simon Teague

Mol Pharm· January 2024

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iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System.
Jayne E Hastedt, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Simon Teague

Mol Pharm· July 2022

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iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes.
Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Simon P Teague

Mol Pharm· July 2022

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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
Christopher R Wellaway, Ian R Baldwin, Paul Bamborough, Daniel Barker, Michelle A Bartholomew, Simon Teague

J Med Chem· January 2022

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Multimodal imaging of drug and excipients in rat lungs following an inhaled administration of controlled-release drug laden PLGA microparticles.
Eve Robinson, Paul Giffen, Dave Hassall, Doug Ball, Heather Reid, Simon Teague

Analyst· May 2021

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How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery.
Simon Teague, Klara Valko

Eur J Pharm Sci· December 2017

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Euodenine A: a small-molecule agonist of human TLR4.
Juliette E Neve, Hasanthi P Wijesekera, Sandra Duffy, Ian D Jenkins, Justin A Ripper, Simon J Teague

J Med Chem· February 2014

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Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.
Tim Luker, Roger Bonnert, Steve Brough, Anthony R Cook, Mark R Dickinson, Simon Teague

Bioorg Med Chem Lett· November 2011

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Acylglycinamides as inhibitors of glycine transporter type 1.
Richard Blunt, Roderick Porter, Amanda Johns, David Nash, Gemma Puckey, Simon Teague

Bioorg Med Chem Lett· October 2011

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Learning lessons from drugs that have recently entered the market.
Simon J Teague

Drug Discov Today· May 2011

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Concrete evidence of confusion.
Simon J Teague

Nature· October 2010

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Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.
Anna Maria Capelli, Laura Castelletti, Cristian Salvagno, Beatrice Oliosi, Elisa Di Lenarda, Simon Teague

Bioorg Med Chem Lett· August 2010

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Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
Mikhail Kalinichev, Kathryn R Starr, Simon Teague, Andrea M Bradford, Rod A Porter

Brain Res· May 2010

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Synthesis of heavily substituted 2-aminopyridines by displacement of a 6-methylsulfinyl group.
Simon J Teague

J Org Chem· December 2008

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Discovery of potent CRTh2 (DP2) receptor antagonists.
Timothy N Birkinshaw, Simon J Teague, Claire Beech, Roger V Bonnert, Stephen Hill

Bioorg Med Chem Lett· August 2006

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Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity.
Michael J Stocks, Simon Barber, Rhonan Ford, Frederic Leroux, Steve St-Gallay, Simon Teague

Bioorg Med Chem Lett· July 2005

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Implications of protein flexibility for drug discovery.
Simon J Teague

Nat Rev Drug Discov· July 2003

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Application and limitations of X-ray crystallographic data in structure-based ligand and drug design.
Andrew M Davis, Simon J Teague, Gerard J Kleywegt

Angew Chem Int Ed Engl· June 2003

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Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.
Guy R Seabrook, Kathy G Sutton, Wolfgang Jarolimek, Gregory J Hollingworth, Simon Teague

J Pharmacol Exp Ther· December 2002

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Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis.
Andrew M Davis, Simon J Teague

Angew Chem Int Ed Engl· March 1999

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Solid-Phase Synthesis of Tyrosine Peptide Aldehydes. Analogues of (S)-MAPI.
Patrick Page, Mark Bradley, Iain Walters, Simon Teague

J Org Chem· February 1999

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