Publications by authors named "Tim Luker"

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Deferitazole, a new orally active iron chelator.
Robert C Hider, Xiaole Kong, Vincenzo Abbate, Rachel Harland, Kelly Conlon, Tim Luker

Dalton Trans· March 2015

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trans-2-Tritylcyclohexanol as a chiral auxiliary in permanganate-mediated oxidative cyclization of 2-methylenehept-5-enoates: application to the synthesis of trans-(+)-linalool oxide.
Ali M Al Hazmi, Nadeem S Sheikh, Carole J R Bataille, Azzam A M Al-Hadedi, Sam V Watkin, Tim J Luker

Org Lett· October 2014

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Unusual structure-genotoxicity relationship in mouse lymphoma cells observed with a series of kinase inhibitors.
Michael D Fellows, Tim Luker, Anne Cooper, Michael R O'Donovan

Mutat Res· July 2012

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Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.
Tim Luker, Roger Bonnert, Steve Brough, Anthony R Cook, Mark R Dickinson

Bioorg Med Chem Lett· November 2011

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In silico prediction of acyl glucuronide reactivity.
Tim Potter, Richard Lewis, Tim Luker, Roger Bonnert, Michael A Bernstein

J Comput Aided Mol Des· November 2011

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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.
Tim Luker, Lilian Alcaraz, Kamaldeep K Chohan, Niklas Blomberg, Dearg S Brown

Bioorg Med Chem Lett· October 2011

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Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.
Tim Luker, Roger Bonnert, Jerzy Schmidt, Carol Sargent, Stuart W Paine

Bioorg Med Chem Lett· June 2011

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Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.
Mark C Wenlock, Patrick Barton, Tim Luker

Bioorg Med Chem Lett· June 2011

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Zwitterionic CRTh2 antagonists.
Tim Luker, Roger Bonnert, Stuart W Paine, Jerzy Schmidt, Carol Sargent

J Med Chem· March 2011

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Prediction of efficacious inhalation lung doses via the use of in silico lung retention quantitative structure-activity relationship models and in vitro potency screens.
Anne Cooper, Tim Potter, Tim Luker

Drug Metab Dispos· December 2010

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Molybdenum-mediated carbonylation of aryl halides with nucleophiles using microwave irradiation.
Bryan Roberts, David Liptrot, Lilian Alcaraz, Tim Luker, Michael J Stocks

Org Lett· October 2010

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Enantioselective formal synthesis of eurylene: synthesis of the cis- and trans-THF fragments using oxidative cyclization.
Nadeem S Sheikh, Carole J Bataille, Tim J Luker, Richard C D Brown

Org Lett· June 2010

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Permanganate oxidation of 1,5,9-trienes: stereoselective synthesis of tetrahydrofuran-containing fragments.
Richard C D Brown, Carole J Bataille, Robert M Hughes, Anne Kenney, Tim J Luker

J Org Chem· November 2002

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Synthesis and Further Reactivity of Functionalized Lactam-Derived Enol Triflates.
Tim Luker, Henk Hiemstra, W. Nico Speckamp

J Org Chem· November 1997

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