Publications by authors named "Simon W John"

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Nicotinamide and Pyruvate in Open-Angle Glaucoma (NIC-OAG): A Randomized Controlled Trial on Neuroprotection - Design and Methodology.
Aakriti Garg Shukla, Emmanouil Tsamis, Carlos Gustavo De Moraes, Simon W John, Donald C Hood

Ophthalmol Glaucoma· December 2025

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Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma.
Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Simon Wm John

bioRxiv· March 2025

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Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation.
Ruth A Kelly, Megan S Kuhn, Ester Reina-Torres, Revathi Balasubramanian, Kristin M Perkumas, Simon Wm John

J Clin Invest· February 2025

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Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error.
Seyyedhassan Paylakhi, Cassandre Labelle-Dumais, Nicholas G Tolman, Michael A Sellarole, Yusef Seymens, Simon Wm John

PLoS Genet· March 2018

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Angiopoietin-1 is required for Schlemm's canal development in mice and humans.
Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Simon Wm John

J Clin Invest· December 2017

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Vitamin B modulates mitochondrial vulnerability and prevents glaucoma in aged mice.
Pete A Williams, Jeffrey M Harder, Nicole E Foxworth, Kelly E Cochran, Vivek M Philip, Simon W M John

Science· February 2017

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An In Vitro Perfusion System to Enhance Outflow Studies in Mouse Eyes.
Krishnakumar Kizhatil, Arthur Chlebowski, Nicholas G Tolman, Nelson F Freeburg, Margaret M Ryan, Simon W M John

Invest Ophthalmol Vis Sci· October 2016

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YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.
K Saidas Nair, Mihai Cosma, Narayanan Raghupathy, Michael A Sellarole, Nicholas G Tolman, Simon W M John

Dis Model Mech· August 2016

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Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.
Ryan H Berry, Juan Qu, Simon W M John, Gareth R Howell, Tatjana C Jakobs

PLoS One· June 2016

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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.
Pete A Williams, James R Tribble, Keating W Pepper, Stephen D Cross, B Paul Morgan, Simon W M John

Mol Neurodegener· April 2016

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DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.
Ileana Soto, Gareth R Howell, Cai W John, Joseph L Kief, Richard T Libby, Simon W M John

PLoS One· March 2016

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C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.
Sean M Silverman, Byung-Jin Kim, Garreth R Howell, Joselyn Miller, Simon W M John

Mol Neurodegener· March 2016

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Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease.
Leah C Graham, Jeffrey M Harder, Ileana Soto, Wilhelmine N de Vries, Simon W M John

Sci Rep· February 2016

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Crim1 regulates integrin signaling in murine lens development.
Ying Zhang, Jieqing Fan, Joshua W K Ho, Tommy Hu, Stephen C Kneeland, Simon W M John

Development· January 2016

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Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.
Marcel V Alavi, Mao Mao, Bradley T Pawlikowski, Manana Kvezereli, Jacque L Duncan, Simon W M John

Sci Rep· January 2016

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Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.
Kimberly A Fernandes, Jeffrey M Harder, Pete A Williams, Rebecca L Rausch, Amy E Kiernan, Simon W M John

Exp Eye Res· December 2015

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Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.
Mao Mao, Richard S Smith, Marcel V Alavi, Jeffrey K Marchant, Mihai Cosma, Simon W M John

Invest Ophthalmol Vis Sci· October 2015

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A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator.
Steven T Lee, Pete A Williams, Catherine E Braine, Da-Ting Lin, Simon W M John

IEEE Trans Neural Syst Rehabil Eng· July 2015

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Visual impairment in an optineurin mouse model of primary open-angle glaucoma.
Henry C Tseng, Thorfinn T Riday, Celia McKee, Catherine E Braine, Howard Bomze, Simon W M John

Neurobiol Aging· June 2015

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Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Tin Aung, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, John H Fingert, Simon W M John

Nat Genet· June 2015

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A flexible platform for biofeedback-driven control and personalization of electrical nerve stimulation therapy.
Matthew P Ward, Kurt Y Qing, Kevin J Otto, Robert M Worth, Simon W M John

IEEE Trans Neural Syst Rehabil Eng· May 2015

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Nonvenous origin of dermal lymphatic vasculature.
Ines Martinez-Corral, Maria H Ulvmar, Lukas Stanczuk, Florence Tatin, Krishnakumar Kizhatil, Simon W M John

Circ Res· May 2015

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Animal models of exfoliation syndrome, now and future.
Simon W M John, Jeffrey M Harder, John H Fingert, Michael G Anderson

J Glaucoma· April 2015

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A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Tin Aung, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, John H Fingert, Simon W M John

Nat Genet· April 2015

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Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.
Gareth R Howell, Katharine H MacNicoll, Catherine E Braine, Ileana Soto, Danilo G Macalinao, Simon W M John

Neurobiol Dis· November 2014

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