Publications by authors named "Simon Wisnovsky"

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Antibody-lectin chimeras for glyco-immune checkpoint blockade.
Jessica C Stark, Melissa A Gray, Itziar Ibarlucea-Benitez, Marta Lustig, Annalise Bond, Simon Wisnovsky

Nat Biotechnol· December 2025

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Polysialic acid is upregulated on activated immune cells and negatively regulates anticancer immune activity.
Olivia Drummond-Guy, John Daly, Angeline Wu, Natalie Stewart, Katy Milne, Simon Wisnovsky

Front Oncol· March 2025

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The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9.
Vignesh Krishnamoorthy, John Daly, Jimmy Kim, Lidia Piatnitca, Katie A Yuen, Simon Wisnovsky

Leukemia· February 2025

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Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
Kayvon Pedram, D Judy Shon, Gabrielle S Tender, Natalia R Mantuano, Jason J Northey, Simon P Wisnovsky

Nat Biotechnol· April 2024

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The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
Natalie Stewart, John Daly, Olivia Drummond-Guy, Vignesh Krishnamoorthy, Jessica C Stark, Simon Wisnovsky

J Biol Chem· February 2024

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A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking.
Justin Donnelly, Roarke A Kamber, Simon Wisnovsky, David S Roberts, Egan L Peltan

bioRxiv· January 2024

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Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Green Ahn, Nicholas M Riley, Roarke A Kamber, Simon Wisnovsky, Salvador Moncayo von Hase

Science· October 2023

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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.
Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Simon Wisnovsky

Oncogene· March 2023

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MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
Benjamin A H Smith, Anja Deutzmann, Kristina M Correa, Corleone S Delaveris, Renumathy Dhanasekaran, Simon Wisnovsky

Proc Natl Acad Sci U S A· March 2023

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Identifying Genetic Regulators of Protein-Glycan Interactions with Genome-Wide CRISPR Screening.
Vignesh Krishnamoorthy, John Daly, Simon Wisnovsky

Curr Protoc· January 2023

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Reading the glyco-code: New approaches to studying protein-carbohydrate interactions.
Simon Wisnovsky, Carolyn R Bertozzi

Curr Opin Struct Biol· August 2022

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Bridging Glycomics and Genomics: New Uses of Functional Genetics in the Study of Cellular Glycosylation.
Natalie Stewart, Simon Wisnovsky

Front Mol Biosci· June 2022

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Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
Simon Wisnovsky, Leonhard Möckl, Stacy A Malaker, Kayvon Pedram, Gaelen T Hess

Proc Natl Acad Sci U S A· February 2021

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Metabolic precision labeling enables selective probing of O-linked -acetylgalactosamine glycosylation.
Marjoke F Debets, Omur Y Tastan, Simon P Wisnovsky, Stacy A Malaker, Nikolaos Angelis

Proc Natl Acad Sci U S A· October 2020

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Lysosome-targeting chimaeras for degradation of extracellular proteins.
Steven M Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, Nicholas M Riley

Nature· August 2020

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Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.
Benjamin Schumann, Stacy Alyse Malaker, Simon Peter Wisnovsky, Marjoke Froukje Debets, Anthony John Agbay

Mol Cell· June 2020

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Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes.
Simon Wisnovsky, Sae Rin Jean, Shana O Kelley

Nat Chem Biol· September 2018

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DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA.
Simon Wisnovsky, Tanja Sack, David J Pagliarini, Rebecca R Laposa, Shana O Kelley

ACS Chem Biol· April 2018

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Characterization of Trypanosoma cruzi MutY DNA glycosylase ortholog and its role in oxidative stress response.
Marianna Kunrath-Lima, Bruno Marçal Repolês, Ceres Luciana Alves, Carolina Furtado, Matheus Andrade Rajão, Simon Wisnovsky

Infect Genet Evol· November 2017

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Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron.
Roxana Y P Alta, Hector A Vitorino, Dibakar Goswami, Cleber W Liria, Simon P Wisnovsky

PLoS One· August 2017

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Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria.
Sae Rin Jean, Marya Ahmed, Eric K Lei, Simon P Wisnovsky, Shana O Kelley

Acc Chem Res· September 2016

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Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell.
Simon Wisnovsky, Eric K Lei, Sae Rin Jean, Shana O Kelley

Cell Chem Biol· August 2016

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Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes.
Simon Wisnovsky, Sae Rin Jean, Shana O Kelley

Nat Chem Biol· July 2016

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Molecular vehicles for mitochondrial chemical biology and drug delivery.
Sae Rin Jean, David V Tulumello, Simon P Wisnovsky, Eric K Lei, Mark P Pereira

ACS Chem Biol· February 2014

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Targeting mitochondrial DNA with a platinum-based anticancer agent.
Simon P Wisnovsky, Justin J Wilson, Robert J Radford, Mark P Pereira, Maria R Chan

Chem Biol· November 2013

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