Publications by authors named "Simone Difilippantonio"

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Activity of direct KRAS(G12C) inhibitors in preclinical models of pediatric cancer.
Hannah E Price, Stacey Stauffer, Hyun Lee, Kristine A Isanogle, Ying Wu, Simone Difilippantonio

Mol Cancer Ther· December 2025

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Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy.
Muhammad Kazim, Arghya Ganguly, Sebastian M Malespini, Lai Thang, Nimit L Patel, Simone Difilippantonio

J Am Chem Soc· October 2025

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A CSF-1R inhibitor both prevents and treats triple-negative breast cancer brain metastases in hematogenous preclinical models.
Wei Zhang, Samiur Rahman, Alex M L Wu, Kristine Isanogle, Christina Robinson, Simone Difilippantonio

Clin Exp Metastasis· August 2025

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IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia.
Scott B Hoyt, Chris J Finocchio, Elizabeth Croll, Gregory J Tawa, Mingliang Zhang, Simone Difilippantonio

ACS Med Chem Lett· May 2025

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Transfer RNA acetylation regulates in vivo mammalian stress signaling.
Supuni Thalalla Gamage, Roxane Khoogar, Shereen Howpay Manage, Judey T DaRos, McKenna C Crawford, Simone Difilippantonio

Sci Adv· March 2025

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Granzyme-targeting quenched activity-based probes for assessing tumor response to immunotherapy.
Muhammad Kazim, Arghya Ganguly, Sebastian M Malespini, Lai Thang, Nimit L Patel, Simone Difilippantonio

bioRxiv· March 2025

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Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.
Susana S Najera, Christopher J Ricketts, Laura S Schmidt, Julia I Medina, Keita Saito, Simone Difilippantonio

Mol Cancer Ther· February 2025

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Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.
Amy L Funk, Meghri Katerji, Marwa Afifi, Katherine Nyswaner, Carolyn C Woodroofe, Simone Difilippantonio

Sci Signal· February 2025

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High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma.
Tara Gelb, Khalid A Garman, Daniel Urban, Amy Coxon, Berkley Gryder, Simone Difilippantonio

Nat Commun· February 2025

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Metastatic organotropism in small cell lung cancer.
Manan Krishnamurthy, Anjali Dhall, Sarthak Sahoo, Christopher W Schultz, Michelle A Baird, Simone Difilippantonio

bioRxiv· January 2025

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Immune profile diversity is achieved with synthetic TLR4 agonists combined with the RG1-VLP vaccine in mice.
Rebecca L Matthews, Nazneen Khan, Bradley Beckman, Simran Sharma, Zackary Dietz, Simone Difilippantonio

Vaccine· January 2025

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Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia.
Scott B Hoyt, Chris J Finocchio, Elizabeth Croll, Gregory J Tawa, Huixu Li, Simone Difilippantonio

ACS Med Chem Lett· November 2024

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Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.
Amy L Funk, Meghri Katerji, Marwa Afifi, Katherine Nyswaner, Carolyn C Woodroofe, Simone Difilippantonio

bioRxiv· November 2024

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Toward a CRISPR-based mouse model of -deficient clear cell kidney cancer: Initial experience and lessons learned.
Laura A Stransky, Wenhua Gao, Laura S Schmidt, Kevin Bi, Christopher J Ricketts, Simone Difilippantonio

Proc Natl Acad Sci U S A· October 2024

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Gα13 restricts nutrient driven proliferation in mucosal germinal centers.
Hang T Nguyen, Moyi Li, Rahul Vadakath, Keirstin A Henke, Tam C Tran, Simone Difilippantonio

Nat Immunol· September 2024

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Enhancing Standard of Care Chemotherapy Efficacy Using DNA-Dependent Protein Kinase (DNA-PK) Inhibition in Preclinical Models of Ewing Sarcoma.
Victor J Collins, Katelyn R Ludwig, Ariana E Nelson, Soumya Sundara Rajan, Choh Yeung, Simone Difilippantonio

Mol Cancer Ther· August 2024

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Transfer RNA acetylation regulates in vivo mammalian stress signaling.
Supuni Thalalla Gamage, Roxane Khoogar, Shereen Howpay Manage, McKenna C Crawford, Joe Georgeson, Simone Difilippantonio

bioRxiv· July 2024

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Distinct uptake and elimination profiles for trastuzumab, human IgG, and biocytin-TMR in experimental HER2+ brain metastases of breast cancer.
Vanesa L Silvestri, Andy D Tran, Monika Chung, Natalie Chung, Brunilde Gril, Simone Difilippantonio

Neuro Oncol· June 2024

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Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma.
Stacey Stauffer, Jacob S Roth, Edjay R Hernandez, Joshua T Kowalczyk, Nancy E Sealover, Simone Difilippantonio

Cancers (Basel)· June 2024

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Analysis of Nanoparticles' Potential to Induce Autoimmunity.
Barry W Neun, Timothy M Potter, Christina Robinson, Simone Difilippantonio, Elijah Edmondson

Methods Mol Biol· March 2024

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Analysis of Nanoparticles' Effects on Drug-Induced Psoriasis.
Ankit Shah, Chelsea Sanders, Simone Difilippantonio, Elijah Edmondson, Marina A Dobrovolskaia

Methods Mol Biol· March 2024

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Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability.
Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Simone Difilippantonio

Cell Rep· December 2023

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Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer.
Yurong Song, Travis D Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S Baxter, Simone Difilippantonio

Front Oncol· September 2023

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Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma.
Jerry T Wu, Adam Cheuk, Kristine Isanogle, Christina Robinson, Xiaohu Zhang, Simone Difilippantonio

Cancers (Basel)· August 2023

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The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells.
Keqiang Chen, John McCulloch, Rodrigo Das Neves, Gisele Rodrigues, Wang-Ting Hsieh, Simone Difilippantonio

Gut Pathog· June 2023

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