Publications by authors named "Simone Eggert"

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Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system.
Liu Ye, Vinicius Daguano Gastaldi, Yasmina Curto, Anne-Fleur Wildenburg, Xuan Yu, Simone Eggert

Nat Commun· September 2025

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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Andrew Octavian Sasmita, Constanze Depp, Taisiia Nazarenko, Ting Sun, Sophie B Siems, Simone Eggert

Nat Neurosci· September 2024

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APP family member dimeric complexes are formed predominantly in synaptic compartments.
Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M Tremmel, Simone Eggert

Cell Biosci· August 2023

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Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Simone Eggert

Acta Neuropathol Commun· June 2023

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The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease.
Lukas Busch, Simone Eggert, Kristina Endres, Bernd Bufe

Cells· October 2022

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The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research.
Vu Thu Thuy Nguyen, Svenja König, Simone Eggert, Kristina Endres, Stefan Kins

Biol Chem· January 2022

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Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease.
Simone Eggert, Stefan Kins, Kristina Endres, Tanja Brigadski

Biol Chem· January 2022

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The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif.
Simone Eggert, Tomas Gruebl, Ritu Rajender, Carsten Rupp, Bianca Sander

Cell Mol Life Sci· December 2020

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Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways.
Alexander August, Nadine Schmidt, Johannes Klingler, Frederik Baumkötter, Marius Lechner, Simone Eggert

J Neurochem· December 2019

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Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.
Simone Eggert, Carolin Thomas, Stefan Kins, Guido Hermey

Mol Neurobiol· July 2018

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Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Simone Eggert, A C Gonzalez, C Thomas, S Schilling, S M Schwarz

Cell Mol Life Sci· January 2018

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APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Sandra Schilling, Annika Mehr, Susann Ludewig, Jonathan Stephan, Marius Zimmermann, Simone Eggert

J Neurosci· May 2017

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Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Lukas P Feilen, Kevin Haubrich, Paul Strecker, Sabine Probst, Simone Eggert

Front Mol Neurosci· May 2017

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LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.
Uta-Mareike Herr, Paul Strecker, Steffen E Storck, Carolin Thomas, Verena Rabiej, Simone Eggert

Front Mol Neurosci· April 2017

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Shedding of APP limits its synaptogenic activity and cell adhesion properties.
Ronny Stahl, Sandra Schilling, Peter Soba, Carsten Rupp, Tobias Hartmann, Simone Eggert

Front Cell Neurosci· December 2014

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Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.
Frederik Baumkötter, Nadine Schmidt, Carolyn Vargas, Sandra Schilling, Rebecca Weber, Simone Eggert

J Neurosci· August 2014

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A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.
Anika Thyrock, Edith Ossendorf, Martin Stehling, Mark Kail, Tanja Kurtz, Simone Eggert

PLoS One· January 2014

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Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62.
Hyun-Jung Jung, Yoon-Jeong Kim, Simone Eggert, Kwang Chul Chung, Kyeong Sook Choi

Exp Neurol· October 2013

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Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.
Alan H Nagahara, Michael Mateling, Imre Kovacs, Ling Wang, Simone Eggert

J Neurosci· September 2013

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Amyloid precursor protein (APP) regulates synaptic structure and function.
Sheue-Houy Tyan, Ann Yu-Jung Shih, Jessica J Walsh, Hiroko Maruyama, Floyd Sarsoza, Simone Eggert

Mol Cell Neurosci· August 2012

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Structural aspects and physiological consequences of APP/APLP trans-dimerization.
Frederik Baumkötter, Katja Wagner, Simone Eggert, Klemens Wild, Stefan Kins

Exp Brain Res· April 2012

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APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Simone Isbert, Katja Wagner, Simone Eggert, Andrea Schweitzer, Gerd Multhaup

Cell Mol Life Sci· April 2012

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Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.
Brea Midthune, Sheue-Houy Tyan, Jessica J Walsh, Floyd Sarsoza, Simone Eggert

Mol Cell Neurosci· April 2012

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
Thomas L Kukar, Thomas B Ladd, Paul Robertson, Sean A Pintchovski, Brenda Moore, Simone Eggert

J Biol Chem· November 2011

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Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.
Simone Eggert, Brea Midthune, Barbara Cottrell, Edward H Koo

J Biol Chem· October 2009

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