Publications by authors named "Simone Lieb"

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Co-targeting SOS1 enhances the antitumor effects of KRAS inhibitors by addressing intrinsic and acquired resistance.
Venu Thatikonda, Hengyu Lyu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Simone Lieb

Nat Cancer· September 2024

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Combined KRAS and SOS1 inhibition enhances and extends the anti-tumor response in KRAS-driven cancers by addressing intrinsic and acquired resistance.
Venu Thatikonda, Hengyu Lu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Simone Lieb

bioRxiv· January 2023

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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Simone Lieb

Nat Cancer· July 2022

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Simone Lieb

Cancer Discov· January 2021

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Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer

Life Sci Alliance· January 2021

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STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Petra van der Lelij, Joseph A Newman, Simone Lieb, Julian Jude, Vittorio Katis

Life Sci Alliance· July 2020

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Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz

Elife· March 2019

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Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases.
Frank Hilberg, Ulrike Tontsch-Grunt, Anke Baum, Anh T Le, Robert C Doebele, Simone Lieb

J Pharmacol Exp Ther· March 2018

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Synthetic lethality between the cohesin subunits and in diverse cancer contexts.
Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos

Elife· July 2017

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.
Martin Steegmaier, Matthias Hoffmann, Anke Baum, Péter Lénárt, Mark Petronczki, Simone Lieb

Curr Biol· February 2007

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