Publications by authors named "Simone Ottonello"

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Small molecules targeting the eubacterial β-sliding clamp discovered by combined and screening approaches.
Alessia Caputo, Gian Marco Elisi, Elisabetta Levati, Giulia Barotti, Sara Sartini, Simone Ottonello

J Enzyme Inhib Med Chem· December 2025

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Exploiting SpyTag/SpyCatcher Technology to Design New Artificial Catalytic Copper Proteins.
Silvia Gentili, Francesca Miglioli, Valentina Borghesani, Gloria Spagnoli, Denise Bellotti, Simone Ottonello

Chembiochem· July 2025

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Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis.
Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Simone Ottonello

Respir Res· July 2025

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Broad Neutralization Capacity of an Engineered Thermostable Three-Helix Angiotensin-Converting Enzyme 2 Polypeptide Targeting the Receptor-Binding Domain of SARS-CoV-2.
Davide Cavazzini, Elisabetta Levati, Saveria Germani, Bao Loc Ta, Lara Monica, Simone Ottonello

Int J Mol Sci· November 2024

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity.
Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Simone Ottonello

NPJ Vaccines· June 2024

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Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity.
Yueru Zhang, Filipe Colaco Mariz, Peter Sehr, Gloria Spagnoli, Karl Moritz Koenig, Simone Ottonello

NPJ Vaccines· February 2024

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A dry powder formulation for peripheral lung delivery and absorption of an anti-SARS-CoV-2 ACE2 decoy polypeptide.
Stefania Glieca, Davide Cavazzini, Elisabetta Levati, Valentina Garrapa, Angelo Bolchi, Simone Ottonello

Eur J Pharm Sci· December 2023

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Time-course transcriptome analysis of a double challenge bleomycin-induced lung fibrosis rat model uncovers ECM homoeostasis-related translationally relevant genes.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Simone Ottonello

BMJ Open Respir Res· September 2023

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Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations.
Camilla Tiezzi, Andrea Vecchi, Marzia Rossi, Davide Cavazzini, Angelo Bolchi, Simone Ottonello

iScience· June 2023

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Time-resolved transcriptomic profiling of the developing rabbit's lungs: impact of premature birth and implications for modelling bronchopulmonary dysplasia.
Matteo Storti, Maria Laura Faietti, Xabier Murgia, Chiara Catozzi, Ilaria Minato, Simone Ottonello

Respir Res· March 2023

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A broadly protective vaccine against cutaneous human papillomaviruses.
Filipe Colaco Mariz, Kathrin Balz, Manuela Dittrich, Yueru Zhang, Fan Yang, Simone Ottonello

NPJ Vaccines· October 2022

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An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation.
Alessia Caputo, Sara Sartini, Elisabetta Levati, Ilaria Minato, Gian Marco Elisi, Simone Ottonello

Antibiotics (Basel)· October 2022

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Enhanced immunogenicity of a positively supercharged archaeon thioredoxin scaffold as a cell-penetrating antigen carrier for peptide vaccines.
Davide Cavazzini, Gloria Spagnoli, Filipe Colaco Mariz, Filippo Reggiani, Stefano Maggi, Simone Ottonello

Front Immunol· August 2022

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A respirable HPV-L2 dry-powder vaccine with GLA as amphiphilic lubricant and immune-adjuvant.
Irene Rossi, Gloria Spagnoli, Francesca Buttini, Fabio Sonvico, Fabio Stellari, Simone Ottonello

J Control Release· December 2021

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Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm.
Carolina Boni, Davide Cavazzini, Angelo Bolchi, Marzia Rossi, Andrea Vecchi, Simone Ottonello

Front Immunol· October 2021

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Broad Neutralization Responses Against Oncogenic Human Papillomaviruses Induced by a Minor Capsid L2 Polytope Genetically Incorporated Into Bacterial Ferritin Nanoparticles.
Fan Yang, Filipe C Mariz, Xueer Zhao, Gloria Spagnoli, Simone Ottonello

Front Immunol· June 2021

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Combined prophylactic and therapeutic immune responses against human papillomaviruses induced by a thioredoxin-based L2-E7 nanoparticle vaccine.
Xueer Zhao, Fan Yang, Filipe Mariz, Wolfram Osen, Angelo Bolchi, Simone Ottonello

PLoS Pathog· September 2020

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Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study.
Enrico Baruffini, Roberta Ruotolo, Franco Bisceglie, Serena Montalbano, Simone Ottonello

Sci Rep· June 2020

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Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.
Roberta Ruotolo, Ilaria Minato, Pietro La Vitola, Luisa Artioli, Claudio Curti, Simone Ottonello

Mol Nutr Food Res· March 2020

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Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection.
Valeria Barili, Paola Fisicaro, Barbara Montanini, Greta Acerbi, Anita Filippi, Simone Ottonello

Nat Commun· January 2020

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New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an BRET-Based Discovery Platform.
Sara Sartini, Elisabetta Levati, Martina Maccesi, Matteo Guerra, Gilberto Spadoni, Simone Ottonello

ACS Chem Biol· August 2019

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Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal truffle lifestyle.
Claude Murat, Thibaut Payen, Benjamin Noel, Alan Kuo, Emmanuelle Morin, Simone Ottonello

Nat Ecol Evol· December 2018

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Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models.
Claudia Balducci, Giulia Santamaria, Pietro La Vitola, Edoardo Brandi, Federica Grandi, Simone Ottonello

Neurobiol Aging· October 2018

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Author Correction: A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mycorrhizal fungus Tuber melanosporum.
Davide Cavazzini, Guido Grossi, Elisabetta Levati, Francesca Vallese, Barbara Montanini, Simone Ottonello

Sci Rep· August 2018

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Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles.
Gloria Spagnoli, Somayeh Pouyanfard, Davide Cavazzini, Elena Canali, Stefano Maggi, Simone Ottonello

Sci Rep· December 2017

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