Publications by authors named "Srinivasagan Ramkumar"

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Structural bias in vitamin A metabolism: Why α-retinoids miss the eye.
Sepalika Bandara, Aicha Saadane, Pranesh Ravichandran, Srinivasagan Ramkumar, Johannes von Lintig

J Biol Chem· October 2025

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Maternal genetics and diet modulate vitamin A homeostasis of the offspring and affect the susceptibility to obesity in adulthood in mice.
Ramkumar Srinivasagan, Sebastià Galmés, Denitsa Vasileva, Paula Rubí, Andreu Palou

Am J Physiol Endocrinol Metab· September 2024

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LRAT coordinates the negative-feedback regulation of intestinal retinoid biosynthesis from β-carotene.
Srinivasagan Ramkumar, Jean Moon, Marcin Golczak, Johannes von Lintig

J Lipid Res· July 2024

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Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.
Zongbo Wei, Caili Hao, Kazi Rafsan Radeen, Ramkumar Srinivasagan, Jian-Kang Chen

Sci Adv· April 2024

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Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6.
Srinivasagan Ramkumar, Beata Jastrzebska, Diego Montenegro, Janet R Sparrow, Johannes von Lintig

J Biol Chem· March 2024

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Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research.
Linda D Thomas, Srinivasagan Ramkumar, Marcin Golczak, Johannes von Lintig

Mol Metab· July 2023

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ASTER-B regulates mitochondrial carotenoid transport and homeostasis.
Sepalika Bandara, Jean Moon, Srinivasagan Ramkumar, Johannes von Lintig

J Lipid Res· May 2023

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Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice.
Jean Moon, Srinivasagan Ramkumar, Johannes von Lintig

Hum Mol Genet· February 2023

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Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A.
Jean Moon, Srinivasagan Ramkumar, Johannes von Lintig

J Lipid Res· June 2022

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Diabetes Aggravates Photoreceptor Pathologies in a Mouse Model for Ocular Vitamin A Deficiency.
Srinivasagan Ramkumar, Vipul M Parmar, Jean Moon, Chieh Lee, Patricia R Taylor

Antioxidants (Basel)· June 2022

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Aster proteins mediate carotenoid transport in mammalian cells.
Sepalika Bandara, Srinivasagan Ramkumar, Sanae Imanishi, Linda D Thomas, Onkar B Sawant

Proc Natl Acad Sci U S A· April 2022

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The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling.
Srinivasagan Ramkumar, Vipul M Parmar, Ivy Samuels, Nathan A Berger, Beata Jastrzebska

Hum Mol Genet· February 2022

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Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts.
Zongbo Wei, Caili Hao, Ramkumar Srinivasagan, Hongli Wu, Jian-Kang Chen

Invest Ophthalmol Vis Sci· December 2021

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Disturbed retinoid metabolism upon loss of impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina.
Domino K Schlegel, Srinivasagan Ramkumar, Johannes von Lintig, Stephan Cf Neuhauss

Elife· October 2021

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Aging lens epithelium is susceptible to ferroptosis.
Zongbo Wei, Caili Hao, Jingru Huangfu, Ramkumar Srinivasagan, Xiang Zhang

Free Radic Biol Med· May 2021

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The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2.
Sepalika Bandara, Linda D Thomas, Srinivasagan Ramkumar, Nimesh Khadka, Philip D Kiser

ACS Chem Biol· March 2021

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Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.
Jennifer M Petrosino, Jacob Z Longenecker, Srinivasagan Ramkumar, Xianyao Xu, Lisa E Dorn

J Clin Invest· February 2021

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Expression and Characterization of Mammalian Carotenoid Cleavage Dioxygenases.
Linda Dora Thomas, Srinivasagan Ramkumar, Johannes von Lintig

Methods Mol Biol· January 2021

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Carotenoid metabolism at the intestinal barrier.
Johannes von Lintig, Jean Moon, Joan Lee, Srinivasagan Ramkumar

Biochim Biophys Acta Mol Cell Biol Lipids· November 2020

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The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.
Linda D Thomas, Sepalika Bandara, Vipulkumar M Parmar, Ramkumar Srinivasagan, Nimesh Khadka

J Biol Chem· November 2020

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Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice.
Lei Wu, Yi Lyu, Ramkumar Srinivasagan, Jinlong Wu, Babajide Ojo

J Nutr· October 2020

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Reactive cysteine residues in the oxidative dimerization and Cu induced aggregation of human γD-crystallin: Implications for age-related cataract.
Srinivasagan Ramkumar, Xingjun Fan, Benlian Wang, Sichun Yang, Vincent M Monnier

Biochim Biophys Acta Mol Basis Dis· November 2018

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The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin.
Mary E Kelly, Srinivasagan Ramkumar, Weizhong Sun, Crystal Colon Ortiz, Philip D Kiser

ACS Chem Biol· August 2018

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Protective role of carotenoids in the visual cycle.
Made Airanthi K Widjaja-Adhi, Srinivasagan Ramkumar, Johannes von Lintig

FASEB J· June 2018

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Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/β-Catenin-Mediated Pathway: Relevance for Cataract Therapy.
Zongbo Wei, Jane Caty, Jeremy Whitson, Amy D Zhang, Ramkumar Srinivasagan

Am J Pathol· November 2017

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