Publications by authors named "Stephan Pleschka"

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Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients.
Yvonne Füll, Lara M Schüssele, Hazem Hamza, Helen Hoffmann, Martin Bauer, Stephan Pleschka

Front Immunol· October 2025

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Special Issue "Host Targeted Therapeutics Against Virus Infections".
Stephan Pleschka

Viruses· November 2024

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Distinct negative-sense RNA viruses induce a common set of transcripts encoding proteins forming an extensive network.
Nina Hofmann, Marek Bartkuhn, Stephan Becker, Nadine Biedenkopf, Eva Böttcher-Friebertshäuser, Stephan Pleschka

J Virol· October 2024

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Differential transcriptomic host responses in the early phase of viral and bacterial infections in human lung tissue explants ex vivo.
Aaqib Sohail, Fakhar H Waqas, Peter Braubach, Laurien Czichon, Mohamed Samir, Stephan Pleschka

Respir Res· October 2024

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Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients.
Benjamin Koch, Mahmoud Shehata, Christin Müller-Ruttloff, Shady A Gouda, Nils Wetzstein, Stephan Pleschka

Front Cell Infect Microbiol· April 2024

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NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.
Fakhar H Waqas, Mahmoud Shehata, Walid A M Elgaher, Antoine Lacour, Naziia Kurmasheva, Stephan Pleschka

PLoS Pathog· July 2023

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MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases.
Stephan Ludwig, Stephan Pleschka, Oliver Planz

Curr Opin Virol· April 2023

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Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5'-termini of RNA and polymerase function.
Lu Liu, Ramakanth Madhugiri, Vera Vivian Saul, Susanne Bacher, Michael Kracht, Stephan Pleschka

Sci Rep· April 2023

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Assessing compatibility and viral fitness between poultry-adapted H9N2 and wild bird-derived neuraminidases.
Anishia Wasberg, Inês R Faria, Julia Bergholm, Philipp P Petric, Ahmed Mostafa, Stephan Pleschka

Sci Rep· March 2023

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Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.
Lu Liu, Axel Weber, Uwe Linne, Mahmoud Shehata, Stephan Pleschka

mBio· February 2023

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Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses.
David Scheibner, Ahmed H Salaheldin, Ola Bagato, Luca M Zaeck, Ahmed Mostafa, Stephan Pleschka

PLoS Pathog· February 2023

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Differential Impact of Specific Amino Acid Residues on the Characteristics of Avian Influenza Viruses in Mammalian Systems.
Dayly Mashaal, Sara H Mahmoud, Christin Müller, Noura M Abo Shama, Amal Abo Kamer, Stephan Pleschka

Pathogens· November 2022

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Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.
Aaqib Sohail, Azeem A Iqbal, Nishika Sahini, Fangfang Chen, Mohamed Tantawy, Stephan Pleschka

PLoS Pathog· November 2022

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Broad Antiviral Effects of against SARS-CoV-2 Variants of Concern and Potential Mechanism of Action.
Selvarani Vimalanathan, Mahmoud Shehata, Kannan Sadasivam, Serena Delbue, Maria Dolci, Stephan Pleschka

Microorganisms· October 2022

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Comparative kinase activity profiling of pathogenic influenza A viruses reveals new anti- and pro-viral protein kinases.
Lu Liu, Astrid Weiß, Vera Vivian Saul, Ralph Theo Schermuly, Stephan Pleschka

J Gen Virol· June 2022

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Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity.
Wiebke Obermann, Alexandra Friedrich, Ramakanth Madhugiri, Paul Klemm, Jan Philipp Mengel, Stephan Pleschka

Viruses· March 2022

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Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.
Aaqib Sohail, Azeem A Iqbal, Nishika Sahini, Fangfang Chen, Mohamed Tantawy, Stephan Pleschka

PLoS Pathog· January 2022

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Ancestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs.
Wen Su, Rhodri Harfoot, Yvonne C F Su, Jennifer DeBeauchamp, Udayan Joseph, Stephan Pleschka

Nat Microbiol· November 2021

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The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo.
Christin Müller, Wiebke Obermann, Nadja Karl, Hans-Guido Wendel, Gaspar Taroncher-Oldenburg, Stephan Pleschka

Antiviral Res· February 2021

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Improved Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002.
Hazem Hamza, Mahmoud M Shehata, Ahmed Mostafa, Stephan Pleschka, Oliver Planz

Front Microbiol· February 2021

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Anti-Influenza Activity of the Ribonuclease Binase: Cellular Targets Detected by Quantitative Proteomics.
Vera Ulyanova, Raihan Shah Mahmud, Alexander Laikov, Elena Dudkina, Maria Markelova, Stephan Pleschka

Int J Mol Sci· November 2020

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PA from a Recent H9N2 (G1-Like) Avian Influenza a Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems.
Ahmed Mostafa, Sara H Mahmoud, Mahmoud Shehata, Christin Müller, Ahmed Kandeil, Stephan Pleschka

Viruses· September 2020

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Genetic incompatibilities and reduced transmission in chickens may limit the evolution of reassortants between H9N2 and panzootic H5N8 clade 2.3.4.4 avian influenza virus showing high virulence for mammals.
Ahmed Mostafa, Claudia Blaurock, David Scheibner, Christin Müller, Ulrike Blohm, Stephan Pleschka

Virus Evol· July 2020

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Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model.
Martin Laure, Hazem Hamza, Julia Koch-Heier, Martin Quernheim, Christin Müller, Stephan Pleschka

Antiviral Res· June 2020

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Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection.
Sebastian Schloer, Jonas Goretzko, Stephan Pleschka, Stephan Ludwig, Ursula Rescher

Viruses· June 2020

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