Publications by authors named "Stephane Raeppel"

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An alignment-independent three-dimensional quantitative structure-activity relationship study on ron receptor tyrosine kinase inhibitors.
Omid Zarei, Stéphane L Raeppel, Maryam Hamzeh-Mivehroud

J Bioinform Comput Biol· June 2022

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Ligand-based Discovery of Novel Small Molecule Inhibitors of RON Receptor Tyrosine Kinase.
Omid Zarei, Najme Faham, Hariprasad Vankayalapati, Stéphane L Raeppel, Alana L Welm

Mol Inform· January 2022

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A potential signaling axis between RON kinase receptor and hypoxia-inducible factor-1 alpha in pancreatic cancer.
Akihisa Kato, Serina Ng, Amalraj Thangasamy, Haiyong Han, Wendi Zhou, Stephane Raeppel

Mol Carcinog· November 2021

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When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?
Anne-Marie Baird, David Easty, Monika Jarzabek, Liam Shiels, Alex Soltermann, Stéphane Raeppel

Front Endocrinol (Lausanne)· February 2019

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Design and synthesis of constrained analogs of LCRF-0004 as potent RON tyrosine kinase inhibitors.
Stéphane L Raeppel, Eric Therrien, Franck Raeppel

Bioorg Med Chem Lett· September 2015

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Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004.
Franck Raeppel, Stéphane L Raeppel, Eric Therrien

Bioorg Med Chem Lett· September 2015

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Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor.
Stéphane L Raeppel, Franck Raeppel, Eric Therrien

Bioorg Med Chem Lett· June 2015

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Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors.
Stéphane L Raeppel, Frédéric Gaudette, Hannah Nguyen, Normand Beaulieu, James Wang

Int J Med Chem· May 2015

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Identification of a novel series of potent RON receptor tyrosine kinase inhibitors.
Stéphane Raeppel, Frédéric Gaudette, Michael Mannion, Stephen Claridge, Oscar Saavedra

Bioorg Med Chem Lett· May 2010

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Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups.
Frédéric Gaudette, Stéphane Raeppel, Hannah Nguyen, Normand Beaulieu, Carole Beaulieu

Bioorg Med Chem Lett· February 2010

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N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Michael Mannion, Stéphane Raeppel, Stephen Claridge, Nancy Zhou, Oscar Saavedra, Franck Raeppel

Bioorg Med Chem Lett· December 2009

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N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Oscar Saavedra, Stephen Claridge, Lijie Zhan, Franck Raeppel, Marie-Claude Granger, Stéphane Raeppel

Bioorg Med Chem Lett· December 2009

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N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Stéphane Raeppel, Stephen Claridge, Oscar Saavedra, Frédéric Gaudette, Lijie Zhan, Franck Raeppel

Bioorg Med Chem Lett· March 2009

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SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
Stéphane Raeppel, Nancy Zhou, Frédéric Gaudette, Silvana Leit, Isabelle Paquin

Bioorg Med Chem Lett· February 2009

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Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
Nancy Zhou, Oscar Moradei, Stephane Raeppel, Silvana Leit, Sylvie Frechette

J Med Chem· July 2008

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Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.
Isabelle Paquin, Stéphane Raeppel, Silvana Leit, Frédéric Gaudette, Nancy Zhou, Franck Raeppel

Bioorg Med Chem Lett· February 2008

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4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.
Sylvie Fréchette, Silvana Leit, Soon Hyung Woo, Guillaume Lapointe, Guillaume Jeannotte, Stéphane Raeppel

Bioorg Med Chem Lett· February 2008

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N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.
Arkadii Vaisburg, Isabelle Paquin, Naomy Bernstein, Sylvie Frechette, Frederic Gaudette, Stephane Raeppel

Bioorg Med Chem Lett· December 2007

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Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.
Oscar Moradei, Silvana Leit, Nancy Zhou, Sylvie Fréchette, Isabelle Paquin, Stéphane Raeppel

Bioorg Med Chem Lett· August 2006

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