Publications by authors named "Stephen Durant"

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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours.
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Hülya Dogan, Ewa Gogola, Stephen T Durant

Nat Commun· May 2024

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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
Kurt G Pike, Thomas A Hunt, Bernard Barlaam, David Benstead, Elaine Cadogan, Stephen T Durant

J Med Chem· February 2024

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ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis.
Ben Yi Tew, Alex J Kalfa, Zeyi Yang, Kyle M Hurth, Thomas Simon, Stephen T Durant

Clin Cancer Res· November 2023

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CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors.
Haojian Li, Yue Liu, Yunjie Xiao, Crystal N Wilson, Hui Jen Bai, Stephen T Durant

Proc Natl Acad Sci U S A· February 2023

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ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance.
Massimiliano Mellone, Klaudia Piotrowska, Giulia Venturi, Lija James, Aleksandra Bzura, Stephen Durant

Cancer Res· December 2022

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ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.
S Lindsey Davis, Sarah J Hartman, Stacey M Bagby, Marina Schlaepfer, Betelehem W Yacob, Stephen T Durant

BMC Cancer· October 2022

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ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Balakrishna Koneru, Ahsan Farooqi, Thinh H Nguyen, Wan Hsi Chen, Ashly Hindle, Stephen T Durant

Sci Transl Med· August 2021

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Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Charles R Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T Durant

Br J Cancer· October 2020

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Stephen T Durant

Nat Commun· January 2019

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Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Jeremy Karlin, Jasmine Allen, Syed F Ahmad, Gareth Hughes, Victoria Sheridan, Stephen T Durant

Mol Cancer Ther· August 2018

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Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
Bernard Barlaam, Elaine Cadogan, Andrew Campbell, Nicola Colclough, Allan Dishington, Stephen Durant

ACS Med Chem Lett· August 2018

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The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Stephen T Durant, Li Zheng, Yingchun Wang, Kan Chen, Lingli Zhang

Sci Adv· June 2018

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
Kurt G Pike, Bernard Barlaam, Elaine Cadogan, Andrew Campbell, Yingxue Chen, Stephen T Durant

J Med Chem· May 2018

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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Thomas A Ward, Peter J McHugh, Stephen T Durant

PLoS One· September 2017

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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Jack C Exell, Mark J Thompson, L David Finger, Steven J Shaw, Judit Debreczeni, Stephen T Durant

Nat Chem Biol· October 2016

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An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.
Dominic I James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A Griffiths

F1000Res· April 2016

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
Lauren E Tebay, Holly Robertson, Stephen T Durant, Steven R Vitale, Trevor M Penning

Free Radic Biol Med· November 2015

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Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.
Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall

PLoS One· June 2013

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Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors.
Claire McWhirter, Michael Tonge, Helen Plant, Ian Hardern, Willem Nissink, Stephen T Durant

J Biomol Screen· June 2013

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Telomerase-independent paths to immortality in predictable cancer subtypes.
Stephen T Durant

J Cancer· October 2012

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Metnase promotes restart and repair of stalled and collapsed replication forks.
Leyma P De Haro, Justin Wray, Elizabeth A Williamson, Stephen T Durant, Lori Corwin

Nucleic Acids Res· September 2010

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DNA-PKcs and ATM co-regulate DNA double-strand break repair.
Meena Shrivastav, Cheryl A Miller, Leyma P De Haro, Stephen T Durant, Benjamin P C Chen

DNA Repair (Amst)· August 2009

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p53 methylation--the Arg-ument is clear.
Stephen T Durant, Er Chieh Cho, Nicholas B La Thangue

Cell Cycle· March 2009

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Arginine methylation regulates the p53 response.
Martin Jansson, Stephen T Durant, Er-Chieh Cho, Sharon Sheahan, Mariola Edelmann

Nat Cell Biol· December 2008

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UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.
Stephen T Durant, Kimberly S Paffett, Meena Shrivastav, Graham S Timmins, William F Morgan

Mol Cell Biol· August 2006

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