Publications by authors named "Michael Tonge"

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Scott Boyd, Michael Tonge

J Med Chem· May 2022

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AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in -Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib.
Vikki Flemington, Emma J Davies, David Robinson, Linda C Sandin, Oona Delpuech, Michael Tonge

Mol Cancer Ther· February 2021

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Jason Breed, Michael Tonge

J Med Chem· May 2020

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
Richard A Ward, Mark J Anderton, Paul Bethel, Jason Breed, Calum Cook, Michael Tonge

J Med Chem· December 2019

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Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples.
Ian Sinclair, Martin Bachman, Daniel Addison, Mattias Rohman, David C Murray, Michael E Tonge

Anal Chem· March 2019

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Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
Richard A Ward, Paul Bethel, Calum Cook, Emma Davies, Judit E Debreczeni, Michael Tonge

J Med Chem· April 2017

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Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
Stuart Jones, Jonathan Ahmet, Kelly Ayton, Matthew Ball, Mark Cockerill, Michael Tonge

J Med Chem· December 2016

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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Hazel M Weir, Robert H Bradbury, Mandy Lawson, Alfred A Rabow, David Buttar, Michael Tonge

Cancer Res· June 2016

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Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
Chris De Savi, Robert H Bradbury, Alfred A Rabow, Richard A Norman, Camila de Almeida, Michael Tonge

J Med Chem· October 2015

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A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs).
Rowena Callis, Alfred Rabow, Michael Tonge, Robert Bradbury, Mairi Challinor

J Biomol Screen· July 2015

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Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
Richard A Ward, Nicola Colclough, Mairi Challinor, Judit E Debreczeni, Kay Eckersley, Michael Tonge

J Med Chem· June 2015

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Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors.
Claire McWhirter, Michael Tonge, Helen Plant, Ian Hardern, Willem Nissink

J Biomol Screen· June 2013

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