Publications by authors named "Alfred Rabow"

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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L Dale, Paul R J Davey, Alfred A Rabow

J Med Chem· February 2022

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Potent and selective bivalent inhibitors of BET bromodomains.
Michael J Waring, Huawei Chen, Alfred A Rabow, Graeme Walker, Romel Bobby

Nat Chem Biol· December 2016

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AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Garrett W Rhyasen, Maureen M Hattersley, Yi Yao, Austin Dulak, Wenxian Wang, Alfred A Rabow

Mol Cancer Ther· November 2016

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
Robert H Bradbury, Rowena Callis, Gregory R Carr, Huawei Chen, Edwin Clark, Alfred A Rabow

J Med Chem· September 2016

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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Hazel M Weir, Robert H Bradbury, Mandy Lawson, Alfred A Rabow, David Buttar

Cancer Res· June 2016

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Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
James S Scott, Andrew Bailey, Robert D M Davies, Sébastien L Degorce, Philip A MacFaul, Alfred A Rabow

ACS Med Chem Lett· January 2016

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Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
Chris De Savi, Robert H Bradbury, Alfred A Rabow, Richard A Norman, Camila de Almeida

J Med Chem· October 2015

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A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs).
Rowena Callis, Alfred Rabow, Michael Tonge, Robert Bradbury, Mairi Challinor

J Biomol Screen· July 2015

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AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo.
Sarah A Loddick, Sarah J Ross, Andrew G Thomason, David M Robinson, Graeme E Walker, Alfred Rabow

Mol Cancer Ther· September 2013

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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
Robert H Bradbury, David G Acton, Nicola L Broadbent, A Nigel Brooks, Gregory R Carr, Alfred A Rabow

Bioorg Med Chem Lett· April 2013

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Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.
Robert H Bradbury, Neil J Hales, Alfred A Rabow, Graeme E Walker, David G Acton

Bioorg Med Chem Lett· September 2011

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Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines.
Constance J Glover, Alfred A Rabow, Yasemin G Isgor, Robert H Shoemaker, David G Covell

Biochem Pharmacol· February 2007

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Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases.
David G Covell, Anders Wallqvist, Ruili Huang, Narmada Thanki, Alfred A Rabow

Proteins· May 2005

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Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
Anders Wallqvist, Anne Monks, Alfred A Rabow, Narmada Thanki, Robert H Shoemaker

Prog Cell Cycle Res· December 2003

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Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data.
Anders Wallqvist, Alfred A Rabow, Robert H Shoemaker, Edward A Sausville, David G Covell

Bioinformatics· November 2003

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Molecular classification of cancer: unsupervised self-organizing map analysis of gene expression microarray data.
David G Covell, Anders Wallqvist, Alfred A Rabow, Narmada Thanki

Mol Cancer Ther· March 2003

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Application of high-throughput, molecular-targeted screening to anticancer drug discovery.
Robert H Shoemaker, Dominic A Scudiero, Giovanni Melillo, Michael J Currens, Anne P Monks, Alfred A Rabow

Curr Top Med Chem· March 2002

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Establishing connections between microarray expression data and chemotherapeutic cancer pharmacology.
Anders Wallqvist, Alfred A Rabow, Robert H Shoemaker, Edward A Sausville, David G Covell

Mol Cancer Ther· March 2002

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Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities.
Alfred A Rabow, Robert H Shoemaker, Edward A Sausville, David G Covell

J Med Chem· February 2002

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