Publications by authors named "Stephen H Safe"

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Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3.
Huajun Han, Laurie A Davidson, Yang-Yi Fan, Kerstin K Landrock, Arul Jayaraman, Stephen H Safe

Am J Physiol Gastrointest Liver Physiol· January 2022

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Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in Mice.
Huajun Han, Laurie A Davidson, Martha Hensel, Grace Yoon, Kerstin Landrock, Stephen H Safe

Mol Cancer Res· May 2021

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Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles.
Fang Yang, Jennifer A A DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Stephen H Safe

Microb Cell Fact· November 2020

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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.
Huajun Han, Laurie A Davidson, Yang-Yi Fan, Jennifer S Goldsby, Grace Yoon, Stephen H Safe

EMBO J· October 2020

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CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers.
Subhashree Kumaravel, Sumeet Singh, Sukanya Roy, Lavanya Venkatasamy, Tori K White, Stephen H Safe

Am J Pathol· April 2020

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Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.
Erika L Garcia-Villatoro, Jennifer A A DeLuca, Evelyn S Callaway, Kimberly F Allred, Laurie A Davidson, Stephen H Safe

Am J Physiol Gastrointest Liver Physiol· March 2020

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Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).
Hossam Draz, Alexander A Goldberg, Vladimir I Titorenko, Emma S Tomlinson Guns, Stephen H Safe

Cell Signal· December 2017

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Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer.
Chandraiah Godugu, Ravi Doddapaneni, Stephen H Safe, Mandip Singh

Eur J Pharm Biopharm· November 2016

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Erratum: 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and-independent prostate cancer cells.
Alexander A Goldberg, Hossam Draz, Diana Montes-Grajales, Jesus Olivero-Verbél, Stephen H Safe

Genes Cancer· January 2016

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Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures.
Tracie D Phillips, Molly Richardson, Yi-Shing Lisa Cheng, Lingyu He, Thomas J McDonald, Stephen H Safe

Arch Toxicol· June 2015

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3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.
Alexander A Goldberg, Hossam Draz, Diana Montes-Grajales, Jesus Olivero-Verbél, Stephen H Safe

Genes Cancer· May 2015

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Investigation of macrophage polarization using bone marrow derived macrophages.
Wei Ying, Patali S Cheruku, Fuller W Bazer, Stephen H Safe, Beiyan Zhou

J Vis Exp· June 2013

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Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.
Stephen H Safe, Paul L Prather, Lisa K Brents, Gayathri Chadalapaka, Indira Jutooru

Anticancer Agents Med Chem· December 2012

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The Toxicology Education Summit: building the future of toxicology through education.
Aaron Barchowsky, Lorrene A Buckley, Gary P Carlson, Vanessa A Fitsanakis, Sue M Ford, Stephen H Safe

Toxicol Sci· June 2012

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Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.
Sandeep Sreevalsan, Sonia Joseph, Indira Jutooru, Gayathri Chadalapaka, Stephen H Safe

Anticancer Res· November 2011

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The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells.
Lavanya Reddivari, Jairam Vanamala, Stephen H Safe, J Creighton Miller

Nutr Cancer· October 2010

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Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.
Tiffany G Bredfeldt, K Leigh Greathouse, Stephen H Safe, Mien-Chie Hung, Mark T Bedford

Mol Endocrinol· May 2010

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Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.
Lavanya Reddivari, Jairam Vanamala, Sudhakar Chintharlapalli, Stephen H Safe, J Creighton Miller

Carcinogenesis· October 2007

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Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report.
Anna K Harding, George P Daston, Glen R Boyd, George W Lucier, Stephen H Safe

Environ Health Perspect· August 2006

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Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.
Joann G W Fleming, Thomas E Spencer, Stephen H Safe, Fuller W Bazer

Endocrinology· February 2006

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Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
Marina Konopleva, Weiguo Zhang, Yue-Xi Shi, Teresa McQueen, Twee Tsao, Stephen H Safe

Mol Cancer Ther· February 2006

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Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects.
Paolo Calabrò, Ismael Samudio, Stephen H Safe, James T Willerson, Edward T H Yeh

J Vasc Res· December 2005

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A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.
Rooha Contractor, Ismael J Samudio, Zeev Estrov, David Harris, James A McCubrey, Stephen H Safe

Cancer Res· April 2005

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Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.
Hans E Purkey, Satheesh K Palaninathan, Kathleen C Kent, Craig Smith, Stephen H Safe

Chem Biol· December 2004

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Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions.
Leslie Cizmas, Guo-dong Zhou, Stephen H Safe, Thomas J McDonald, Li Zhu

Environ Mol Mutagen· June 2004

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