Publications by authors named "Stephen N Hewitt"

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Architecture of glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases.
Michael K Fenwick, Stephen J Mayclin, Steve Seibold, Amy E DeRocher, Sandhya Subramanian, Stephen Nakazawa Hewitt

Proc Natl Acad Sci U S A· May 2025

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Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens.
Michael K Fenwick, Phillip G Pierce, Jan Abendroth, Kayleigh F Barrett, Lynn K Barrett, Stephen Nakazawa Hewitt

Commun Biol· December 2024

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Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics.
Garry W Buchko, Stephen N Hewitt, Wesley C Van Voorhis, Peter J Myler

Acta Crystallogr F Struct Biol Commun· January 2018

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Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Stephen Nakazawa Hewitt, David M Dranow, Benjamin G Horst, Jan A Abendroth, Barbara Forte

ACS Infect Dis· January 2017

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Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
Gashaw M Goshu, Debarati Ghose, Joy M Bain, Phillip G Pierce, Darren W Begley, Stephen N Hewitt

Bioorg Med Chem Lett· December 2015

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Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface.
Garry W Buchko, Thomas E Edwards, Stephen N Hewitt, Isabelle Q H Phan, Wesley C Van Voorhis

Biomol NMR Assign· October 2015

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Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.
Garry W Buchko, Jan Abendroth, Matthew C Clifton, Howard Robinson, Yanfeng Zhang, Stephen N Hewitt

Acta Crystallogr F Struct Biol Commun· May 2015

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Increasing the structural coverage of tuberculosis drug targets.
Loren Baugh, Isabelle Phan, Darren W Begley, Matthew C Clifton, Brianna Armour, Stephen N Hewitt

Tuberculosis (Edinb)· March 2015

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Solution structure of a putative FKBP-type peptidyl-propyl cis-trans isomerase from Giardia lamblia.
Garry W Buchko, Stephen N Hewitt, Wesley C Van Voorhis, Peter J Myler

J Biomol NMR· December 2013

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Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins.
David J Leibly, Trang Nhu Nguyen, Louis T Kao, Stephen N Hewitt, Lynn K Barrett

PLoS One· June 2013

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Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.
Garry W Buchko, Jan Abendroth, Howard Robinson, Yanfeng Zhang, Stephen N Hewitt

J Struct Funct Genomics· June 2013

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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
Kayode K Ojo, Claudia Pfander, Natascha R Mueller, Charlotte Burstroem, Eric T Larson, Stephen N Hewitt

J Clin Invest· June 2012

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Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
Eric T Larson, Kayode K Ojo, Ryan C Murphy, Steven M Johnson, Zhongsheng Zhang, Stephen N Hewitt

J Med Chem· March 2012

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Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success.
Ryan Choi, Angela Kelley, David Leibly, Stephen Nakazawa Hewitt, Alberto Napuli

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline.
Stephen N Hewitt, Ryan Choi, Angela Kelley, Gregory J Crowther, Alberto J Napuli

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.
Douglas R Davies, Bart L Staker, Jan A Abendroth, Thomas E Edwards, Robert Hartley, Stephen N Hewitt

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.
Darren W Begley, Douglas R Davies, Robert C Hartley, Stephen N Hewitt, Amanda L Rychel

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.
Garry W Buchko, Thomas E Edwards, Jan Abendroth, Tracy L Arakaki, Laura Law, Stephen N Hewitt

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.
Garry W Buchko, Stephen N Hewitt, Alberto J Napuli, Wesley C Van Voorhis, Peter J Myler

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Garry W Buchko, Stephen N Hewitt, Alberto J Napuli, Wesley C Van Voorhis, Peter J Myler

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2011

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Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head.
Thomas E Edwards, Isabelle Phan, Jan Abendroth, Shellie H Dieterich, Amir Masoudi, Stephen N Hewitt

PLoS One· September 2010

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X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
Jan Abendroth, Michael S McCormick, Thomas E Edwards, Bart Staker, Roderick Loewen, Stephen Nakazawa Hewitt

J Struct Funct Genomics· March 2010

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Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei.
Garry W Buchko, Stephen N Hewitt, Alberto J Napuli, Wesley C Van Voorhis, Peter J Myler

Biomol NMR Assign· December 2009

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