Publications by authors named "Stephen P Jackson"

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MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors.
Hülya Dogan, Martin Liptay, Joana S Barbosa, Ewa Gogola, Alexandra A Duarte, Stephen P Jackson

Oncogene· December 2025

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Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay.
Søren H Hough, Satpal S Jhujh, Samah W Awwad, Oliver E Lewis, Simon Lam, Stephen P Jackson

EMBO Mol Med· December 2025

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WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2.
Jordan C J Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G Lloyd, Simon Lam, Stephen P Jackson

Nat Commun· October 2025

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Cell-stereotyped DNA repair outcomes are widespread during genome editing.
Moritz F Schlapansky, Markus S Schröder, Antonio J Santinha, Tanja Rothgangl, Eleonora I Ioannidi, Stephen P Jackson

bioRxiv· October 2025

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Gene context drift identifies drug targets to mitigate cancer treatment resistance.
Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Stephen P Jackson

Cancer Cell· September 2025

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USP37 prevents premature disassembly of stressed replisomes by TRAIP.
Olga V Kochenova, Giuseppina D'Alessandro, Domenic Pilger, Ernst Schmid, Sean L Richards, Stephen P Jackson

Nat Commun· June 2025

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Transcription-coupled repair of DNA-protein crosslinks.
Christopher J Carnie, Stephen P Jackson, Julian Stingele

Trends Cell Biol· April 2025

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Comprehensive interrogation of synthetic lethality in the DNA damage response.
John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Stephen P Jackson

Nature· April 2025

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USP4 Auto-Deubiquitylation Promotes Homologous Recombination.
Paul Wijnhoven, Rebecca Konietzny, Andrew N Blackford, Jonathan Travers, Benedikt M Kessler, Stephen P Jackson

Mol Cell· February 2025

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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance.
Irena Josephina Johanna Muffels, Hans R Waterham, Giuseppina D'Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Stephen P Jackson

Genome Med· February 2025

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TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition.
Chen Gang Goh, Aldo S Bader, Tuan-Anh Tran, Rimma Belotserkovskaya, Giuseppina D'Alessandro, Stephen P Jackson

Nucleic Acids Res· January 2025

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KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency.
Samah W Awwad, Colm Doyle, Josie Coulthard, Aldo S Bader, Nadia Gueorguieva, Stephen P Jackson

Nat Commun· January 2025

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Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens.
Simon Lam, John C Thomas, Stephen P Jackson

Genome Med· November 2024

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Retraction notice to: hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage.
Abdeladim Moumen, Philip Masterson, Mark J O'Connor, Stephen P Jackson

Cell· October 2024

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USP37 prevents premature disassembly of stressed replisomes by TRAIP.
Olga V Kochenova, Giuseppina D'Alessandro, Domenic Pilger, Ernst Schmid, Sean L Richards, Stephen P Jackson

bioRxiv· September 2024

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Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS.
Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Stephen P Jackson

EMBO J· June 2024

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Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB.
Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Stephen P Jackson

Nat Cell Biol· May 2024

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RAD54L2 counters TOP2-DNA adducts to promote genome stability.
Giuseppina D'Alessandro, David A Morales-Juarez, Sean L Richards, Karin C Nitiss, Almudena Serrano-Benitez, Stephen P Jackson

Sci Adv· December 2023

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Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.
Tracy-Shi Zhang Fang, Yu Sun, Andrew C Pearce, Simona Eleuteri, Mark Kemp, Stephen P Jackson

Nat Commun· November 2023

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Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
Almudena Serrano-Benitez, Sophie E Wells, Lylah Drummond-Clarke, Lilian C Russo, John Christopher Thomas, Stephen P Jackson

EMBO J· September 2023

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Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.
Lena R Kaisinger, Katherine A Kentistou, Stasa Stankovic, Eugene J Gardner, Felix R Day, Stephen P Jackson

Cell Genom· August 2023

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Revolutionizing DNA repair research and cancer therapy with CRISPR-Cas screens.
Samah W Awwad, Almudena Serrano-Benitez, John C Thomas, Vipul Gupta, Stephen P Jackson

Nat Rev Mol Cell Biol· July 2023

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SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
Dawei Sun, Oriol Llora Batlle, Jelle van den Ameele, John C Thomas, Peng He, Stephen P Jackson

EMBO J· November 2022

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Clinical prospects of WRN inhibition as a treatment for MSI tumours.
David A Morales-Juarez, Stephen P Jackson

NPJ Precis Oncol· November 2022

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SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Stephen P Jackson

Nat Commun· June 2022

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