Publications by authors named "Stephen P Watson"

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Expansion microscopy allows quantitative characterization of structural organization of platelet aggregates.
Emma L Faulkner, Jeremy A Pike, Evelyn Garlick, Robert K Neely, Iain B Styles, Stephen P Watson

J Thromb Haemost· August 2025

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Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric disorders.
Simon Poulter, Nigel Austin, Stephen P Watson, Sarah J Bucknell, M Alistair O'Brien

Xenobiotica· March 2025

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The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.
Simon Poulter, Nigel Austin, Rachel Armstrong, Matt Barnes, Sarah Joanne Bucknell, Stephen P Watson

ACS Med Chem Lett· April 2023

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Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Stacey M Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D Cansfield, Stephen P Watson

ACS Med Chem Lett· November 2022

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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
Andrew D Cansfield, Mark A Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Stephen P Watson

ACS Chem Neurosci· March 2022

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Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function.
Malou Zuidscherwoude, Elizabeth J Haining, Victoria A Simms, Stephanie Watson, Beata Grygielska, Stephen P Watson

Platelets· November 2021

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Is the endogenous ligand for PEAR1 a proteoglycan: clues from the sea.
Caroline Kardeby, Foteini-Nafsika Damaskinaki, Yi Sun, Stephen P Watson

Platelets· August 2021

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Antiprothrombin antibodies induce platelet activation: A possible explanation for anti-FXa therapy failure in patients with antiphospholipid syndrome?
Walid Chayoua, Phillip L R Nicolson, Joost C M Meijers, Caroline Kardeby, Lourdes Garcia-Quintanilla, Stephen P Watson

J Thromb Haemost· July 2021

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Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice.
Timo Vögtle, Ayesha A Baig, Julia Volz, Timothy B Duchow, Irina Pleines, Stephen P Watson

Platelets· August 2020

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Fluorescence Approaches Unravel Spatial and Temporal Aspects of GPCR Organisation, Location, and Intracellular Signalling.
Stephen J Hill, Stephen P Watson

Trends Pharmacol Sci· February 2018

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Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.
Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Stephen P Watson

Nat Commun· November 2017

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The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.
Garrick P Smith, Lassina Badolo, Victoria Chell, I-Jen Chen, Kenneth Vielsted Christensen, Stephen P Watson

Bioorg Med Chem Lett· September 2017

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The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.
Steven G Thomas, Natalie S Poulter, Danai Bem, Brenda Finney, Laura M Machesky, Stephen P Watson

Platelets· June 2017

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The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.
Jacob Lauwring Andersen, Samsa Lindberg, Morten Langgård, Philip J Maltas, Lars Christian Biilmann Rønn, Stephen P Watson

Bioorg Med Chem Lett· June 2017

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The role of platelets in the recruitment of leukocytes during vascular disease.
G Ed Rainger, Myriam Chimen, Matthew J Harrison, Clara M Yates, Paul Harrison, Stephen P Watson

Platelets· May 2016

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Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide.
Lucia Cardo, Steve G Thomas, Alexandra Mazharian, Zoe Pikramenou, Joshua Z Rappoport, Stephen P Watson

Chembiochem· July 2015

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Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
Natalie S Poulter, Alice Y Pollitt, Amy Davies, Dessislava Malinova, Gerard B Nash, Stephen P Watson

Nat Commun· June 2015

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The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function.
Thomas Jensen, Lisbeth Elster, Søren Møller Nielsen, Suresh Babu Poda, Frosty Loechel, Stephen P Watson

Bioorg Med Chem Lett· November 2014

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Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets.
Alessandra Borgognone, Kate L Lowe, Stephen P Watson, Melanie Madhani

Platelets· October 2014

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What can proteomics tell us about platelets?
Julia M Burkhart, Stepan Gambaryan, Stephen P Watson, Kerstin Jurk, Ulrich Walter

Circ Res· March 2014

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The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Tenna Juul Schrøder, Søren Christensen, Samsa Lindberg, Morten Langgård, Laurent David, Stephen P Watson

Bioorg Med Chem Lett· January 2014

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G6f-like is an ITAM-containing collagen receptor in thrombocytes.
Craig E Hughes, Uvaraj P Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M Dijkstra, Stephen P Watson

PLoS One· June 2013

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Novel diagnostic assays for heparin-induced thrombocytopenia.
Adam Cuker, Ann H Rux, Jillian L Hinds, May Dela Cruz, Serge V Yarovoi, Stephen P Watson

Blood· May 2013

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Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.
Bruce S Sachais, Ann H Rux, Douglas B Cines, Serge V Yarovoi, Lee I Garner, Stephen P Watson

Blood· June 2012

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Platelet CLEC-2 and podoplanin in cancer metastasis.
Kate L Lowe, Leyre Navarro-Nunez, Stephen P Watson

Thromb Res· April 2012

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