Publications by authors named "Stephen Sykes"

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Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.
Bryan Harris, Dinesh K Singh, Billy Truong, Michele Rhodes, Rachael Price, Stephen Sykes

Cell Rep· December 2025

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A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies.
Fan He, Shuyang Lin, Bei Gao, Varun Ramesh, Alexander B Kim, Stephen M Sykes

Cell Commun Signal· December 2025

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Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders.
Sara M Fielder, Marisa W Friederich, Daniella H Hock, Jessie R Zhang, Liana M Valin, Stephen M Sykes

EMBO Mol Med· October 2025

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Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders.
Sara M Fielder, Marisa W Friederich, Daniella H Hock, Jessie R Zhang, Liana M Valin, Stephen M Sykes

medRxiv· July 2025

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Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells.
Luana Chiquetto, Meg Schuetz, Qian Dong, Mia Warmka, Liana Valin, Stephen Sykes

bioRxiv· March 2025

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Reprogramming of Fatty Acid Metabolism in Acute Leukemia.
Judith Sokei, Joice Kanefsky, Stephen M Sykes

J Cell Physiol· January 2025

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Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.
Nancy B J Arthur, Keegan A Christensen, Kathleen Mannino, Marianna B Ruzinova, Ashutosh Kumar, Stephen M Sykes

Clin Cancer Res· August 2024

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Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death.
Joice Kanefsky, Mary Basse, Judith Sokei, Orsola di Martino, Liana Valin, Stephen M Sykes

J Biol Chem· May 2024

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Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
Fan He, Angelo Ba Laranjeira, Tim Kong, Shuyang Lin, Katrina J Ashworth, Stephen M Sykes

J Clin Invest· February 2024

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Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis.
Nancy Bj Arthur, Keegan A Christensen, Kathleen Mannino, Marianna B Ruzinova, Ashutosh Kumar, Stephen M Sykes

bioRxiv· October 2023

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Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism.
Bryan Harris, Dinesh K Singh, Monika Verma, Shawn P Fahl, Michele Rhodes, Stephen Sykes

bioRxiv· June 2023

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DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Stephen M Sykes

Blood· May 2023

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The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm.
Yong Zhang, Billy Truong, Shawn P Fahl, Esteban Martinez, Kathy Q Cai, Stephen M Sykes

Blood· July 2022

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and Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Stephen M Sykes

Cancer Res· October 2021

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The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22.
Timothy J Stanek, Victoria J Gennaro, Mason A Tracewell, Daniela Di Marcantonio, Kristen L Pauley, Stephen M Sykes

EMBO J· August 2021

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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Daniela Di Marcantonio, Esteban Martinez, Joice S Kanefsky, Jacklyn M Huhn, Rashid Gabbasov, Stephen M Sykes

Mol Cell· July 2021

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BRCA1 Mutational Complementation Induces Synthetic Viability.
Joseph Nacson, Daniela Di Marcantonio, Yifan Wang, Andrea J Bernhardy, Emma Clausen, Stephen M Sykes

Mol Cell· June 2020

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IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development.
Iuliia O Peshkova, Turan Aghayev, Aliia R Fatkhullina, Petr Makhov, Elizaveta K Titerina, Stephen M Sykes

Nat Commun· November 2019

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Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia.
Daniela Di Marcantonio, Stephen M Sykes

J Vis Exp· September 2019

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NCAM1 supports therapy resistance and LSC function in AML.
Stephen M Sykes

Blood· May 2019

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The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity.
Elena Masselli, Cecilia Carubbi, Benedetta Cambò, Giulia Pozzi, Giuliana Gobbi, Stephen M Sykes

Leukemia· October 2018

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Joseph Nacson, John J Krais, Andrea J Bernhardy, Emma Clausen, Wanjuan Feng, Stephen M Sykes

Cell Rep· October 2018

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Joseph Nacson, John J Krais, Andrea J Bernhardy, Emma Clausen, Wanjuan Feng, Stephen M Sykes

Cell Rep· September 2018

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Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Stephen M Sykes

Blood· July 2018

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MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
Silvia Maifrede, Esteban Martinez, Margaret Nieborowska-Skorska, Daniela Di Marcantonio, Michael Hulse, Stephen M Sykes

Blood Adv· August 2017

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