Publications by authors named "Steve Titus"

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Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
Kevin J Frankowski, Samarjit Patnaik, Chen Wang, Noel Southall, Dipannita Dutta, Steve Titus

J Med Chem· June 2022

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Identification of Positive Allosteric Modulators of the D Dopamine Receptor That Act at Diverse Binding Sites.
Kathryn D Luderman, Jennie L Conroy, R Benjamin Free, Noel Southall, Marc Ferrer, Steve Titus

Mol Pharmacol· October 2018

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Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.
Kevin J Frankowski, Chen Wang, Samarjit Patnaik, Frank J Schoenen, Noel Southall, Steve Titus

Sci Transl Med· May 2018

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One-Step Seeding of Neural Stem Cells with Vitronectin-Supplemented Medium for High-Throughput Screening Assays.
Sheng Dai, Rong Li, Yan Long, Steve Titus, Jinghua Zhao

J Biomol Screen· December 2016

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Large-scale pharmacological profiling of 3D tumor models of cancer cells.
Lesley A Mathews Griner, Xiaohu Zhang, Rajarshi Guha, Crystal McKnight, Ian S Goldlust, Steve Titus

Cell Death Dis· December 2016

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ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.
Mahlet B Abera, Jingbo Xiao, Jonathan Nofziger, Steve Titus, Noel Southall

JCI Insight· November 2016

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A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease.
Matthew G Rees, Mindy I Davis, Min Shen, Steve Titus, Anne Raimondo

PLoS One· October 2014

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Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.
R Benjamin Free, Lani S Chun, Amy E Moritz, Brittney N Miller, Trevor B Doyle, Steve Titus

Mol Pharmacol· July 2014

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Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.
Jingbo Xiao, R Benjamin Free, Elena Barnaeva, Jennie L Conroy, Trevor Doyle, Steve Titus

J Med Chem· April 2014

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A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.
Mohammad Samie, Xiang Wang, Xiaoli Zhang, Andrew Goschka, Xinran Li, Steve Titus

Dev Cell· September 2013

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Discovery, synthesis, and biological evaluation of novel SMN protein modulators.
Jingbo Xiao, Juan J Marugan, Wei Zheng, Steve Titus, Noel Southall

J Med Chem· September 2011

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A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
Susanne Neumann, Wenwei Huang, Elena Eliseeva, Steve Titus, Craig J Thomas

Endocrinology· July 2010

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A multiplex calcium assay for identification of GPCR agonists and antagonists.
Ke Liu, Noel Southall, Steve A Titus, James Inglese, Robert L Eskay

Assay Drug Dev Technol· June 2010

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Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Susanne Neumann, Wenwei Huang, Steve Titus, Gerd Krause, Gunnar Kleinau

Proc Natl Acad Sci U S A· July 2009

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Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes.
Hiroshi Kajiyama, Steve Titus, Christopher P Austin, Kathleen Chiotos, Takayuki Matsumoto

Am J Nephrol· June 2009

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Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format.
Ke Liu, Steve Titus, Noel Southall, Pingjun Zhu, James Inglese

Curr Chem Genomics· July 2008

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Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.
Steve Titus, Susanne Neumann, Wei Zheng, Noel Southall, Sam Michael

J Biomol Screen· February 2008

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