Publications by authors named "Steven Do"

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COPD CARE Academy: Design of Purposeful Training Guided by Implementation Strategies.
Edward C Portillo, Steven Do, Tiffany M Parham, Jordyn Kettner, Nora Jacobson

Fed Pract· August 2025

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Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.
Christian Nilewski, Sharada Labadie, Binqing Wei, Sushant Malhotra, Steven Do

ACS Med Chem Lett· January 2024

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
James J Crawford, Jianwen Feng, Hans D Brightbill, Adam R Johnson, Matthew Wright, Georgette M Castanedo, Steven Do

Bioorg Med Chem Lett· June 2023

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Cytochalasin B Treatment and Osmotic Pressure Enhance the Production of Extracellular Vesicles (EVs) with Improved Drug Loading Capacity.
Ashita Nair, Jiyoon Bu, Piper A Rawding, Steven C Do, Hangpeng Li

Nanomaterials (Basel)· December 2021

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Recreational Nitrous Oxide-Induced Subacute Combined Degeneration of the Spinal Cord.
Priyal Agarwal, Si Yuan Khor, Steven Do, Lawrenshey Charles, Richa Tikaria

Cureus· November 2021

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Atrial Fibrillation as a Predictor of Mortality in High Risk COVID-19 Patients: A Multicentre Study of 171 Patients.
Randy J Ip, Abbas Ali, Zulfiqar Qutrio Baloch, Abdullah Al-Abcha, Chris Jacob, Steven Do

Heart Lung Circ· August 2021

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Regarding "The Clinical and Economic Burden of Norovirus Gastroenteritis in the United States".
Steven R Do, Daniel H Havlichek

J Infect Dis· August 2021

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spp. bacteremia from maggot infestation.
Steven R Do, Subhashis Mitra, Christopher Cantoria Garces, Farahnaz Anwar

IDCases· May 2021

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The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Cesar A Corzo, Eugene Varfolomeev, A Francesca Setiadi, Ross Francis, Sha Klabunde, Steven Do, Melanie Domeyer, Domagoj Vucic

Sci Signal· June 2020

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Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
Naomi S Rajapaksa, Alberto Gobbi, Joy Drobnick, Steven Do, Aleksandr Kolesnikov

ACS Med Chem Lett· March 2020

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Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, Grace Ka Yan Chan, Jae H Chang, Steven Do

J Med Chem· February 2019

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Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Huifen Chen, Matthew Volgraf, Steven Do, Aleksandr Kolesnikov, Daniel G Shore

J Med Chem· April 2018

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Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
Xiaojing Wang, Aleksandr Kolesnikov, Suzanne Tay, Grace Chan, Qi Chao, Steven Do

J Med Chem· May 2017

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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Timothy P Heffron, Robert A Heald, Chudi Ndubaku, BinQing Wei, Martin Augistin, Steven Do

J Med Chem· February 2016

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α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.
Vishal A Verma, Daniel G M Shore, Huifen Chen, Jun Chen, Steven Do

Bioorg Med Chem Lett· January 2016

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Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.
Huiyong Hu, Xiaojing Wang, Grace Ka Yan Chan, Jae H Chang, Steven Do

Bioorg Med Chem Lett· November 2015

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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.
Chudi O Ndubaku, Timothy P Heffron, Steven T Staben, Matthew Baumgardner, Nicole Blaquiere, Steven Do, Jennafer Dotson

J Med Chem· June 2013

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Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
Steven T Staben, Nicole Blaquiere, Vickie Tsui, Aleksandr Kolesnikov, Steven Do, Jenna Dotson

Bioorg Med Chem Lett· February 2013

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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.
James F Blake, Rui Xu, Josef R Bencsik, Dengming Xiao, Nicholas C Kallan, Steven Do

J Med Chem· September 2012

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Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform.
Timothy P Heffron, Binqing Wei, Alan Olivero, Steven T Staben, Vickie Tsui, Steven Do, Jennafer Dotson

J Med Chem· November 2011

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Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Steven T Staben, Michael Siu, Richard Goldsmith, Alan G Olivero, Steven Do, Jenna Dotson

Bioorg Med Chem Lett· July 2011

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Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides.
Richland Tester, Xuefei Tan, Gregory R Luedtke, Imad Nashashibi, Kurt Schinzel, Steven Do

Bioorg Med Chem Lett· April 2010

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The relationship between subclinical atherosclerosis and electrocardiographic abnormalities as biomarkers of cardiovascular risk.
Allen J Taylor, Antonio E Rodriguez, Joseph C Lee, Salim B Mathew, Dimitri Cassimatis, Steven Welka Do

Biomarkers· August 2008

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Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation.
Qing Lu, Zheng Chen, John Perumattam, Dan-Xiong Wang, Weiling Liang, Steven Do, Hanmin Dong

Bioorg Med Chem Lett· April 2008

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A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
James G Christensen, Randall Schreck, Jon Burrows, Poonam Kuruganti, Emily Chan, Steven Do

Cancer Res· November 2003

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