Publications by authors named "Matthew Volgraf"

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Discovery of TRPA1 Antagonist : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Jack A Terrett, Justin Q Ly, Paula Katavolos, Catrin Hasselgren, Steven Laing, Matthew Volgraf

J Med Chem· March 2024

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Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Ruth Dorel, Dawei Sun, Nicholas Carruthers, Georgette M Castanedo, Peter M-U Ung, Matthew Volgraf

J Med Chem· March 2024

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Cryo-EM reveals an unprecedented binding site for Na1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Matthew Volgraf

Elife· March 2023

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Ligand binding at the protein-lipid interface: strategic considerations for drug design.
Jian Payandeh, Matthew Volgraf

Nat Rev Drug Discov· September 2021

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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
Elisia Villemure, Jack A Terrett, Robin Larouche-Gauthier, Martin Déry, Huifen Chen, Matthew Volgraf

ACS Med Chem Lett· August 2021

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A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Alessia Balestrini, Victory Joseph, Michelle Dourado, Rebecca M Reese, Shannon D Shields, Matthew Volgraf

J Exp Med· April 2021

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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Jack A Terrett, Huifen Chen, Daniel G Shore, Elisia Villemure, Robin Larouche-Gauthier, Matthew Volgraf

J Med Chem· April 2021

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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Chang Liu, Rebecca Reese, Simon Vu, Lionel Rougé, Shannon D Shields, Matthew Volgraf

Neuron· January 2021

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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Jesse E Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Matthew Volgraf

Cell Rep· January 2020

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TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism.
Tania Chernov-Rogan, Eleonora Gianti, Chang Liu, Elisia Villemure, Andrew P Cridland, Matthew Volgraf

Proc Natl Acad Sci U S A· December 2019

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Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Huifen Chen, Matthew Volgraf, Steven Do, Aleksandr Kolesnikov, Daniel G Shore

J Med Chem· April 2018

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A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain.
Tzu-Ming Wang, Brandon M Brown, Lunbin Deng, Benjamin D Sellers, Patrick J Lupardus, Matthew Volgraf

Neuropharmacology· July 2017

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Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
Xiaojing Wang, Aleksandr Kolesnikov, Suzanne Tay, Grace Chan, Qi Chao, Matthew Volgraf

J Med Chem· May 2017

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GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved Profile.
Elisia Villemure, Matthew Volgraf, Yu Jiang, Guosheng Wu, Cuong Q Ly

ACS Med Chem Lett· January 2017

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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
David H Hackos, Patrick J Lupardus, Teddy Grand, Yelin Chen, Tzu-Ming Wang, Matthew Volgraf

Neuron· March 2016

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Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
Matthew Volgraf, Benjamin D Sellers, Yu Jiang, Guosheng Wu, Cuong Q Ly

J Med Chem· March 2016

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Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Matthew Volgraf, Lina Chan, Malcolm P Huestis, Hans E Purkey, Michael Burkard

Bioorg Med Chem Lett· June 2014

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Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, Ryan J Watts, Xingrong Liu

J Med Chem· February 2014

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Total synthesis of exiguamines A and B inspired by catecholamine chemistry.
Vladimir Sofiyev, Jean-Philip Lumb, Matthew Volgraf, Dirk Trauner

Chemistry· April 2012

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Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.
Rika Numano, Stephanie Szobota, Albert Y Lau, Pau Gorostiza, Matthew Volgraf

Proc Natl Acad Sci U S A· April 2009

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Biomimetic synthesis of the IDO inhibitors exiguamine A and B.
Matthew Volgraf, Jean-Philip Lumb, Harry C Brastianos, Gavin Carr, Marco K W Chung

Nat Chem Biol· September 2008

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All optical interface for parallel, remote, and spatiotemporal control of neuronal activity.
Sheng Wang, Stephanie Szobota, Yuan Wang, Matthew Volgraf, Zhaowei Liu

Nano Lett· December 2007

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Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor.
Pau Gorostiza, Matthew Volgraf, Rika Numano, Stephanie Szobota, Dirk Trauner

Proc Natl Acad Sci U S A· June 2007

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Remote control of neuronal activity with a light-gated glutamate receptor.
Stephanie Szobota, Pau Gorostiza, Filippo Del Bene, Claire Wyart, Doris L Fortin, Matthew Volgraf

Neuron· May 2007

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Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors.
Matthew Volgraf, Pau Gorostiza, Stephanie Szobota, Max R Helix, Ehud Y Isacoff

J Am Chem Soc· January 2007

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