Publications by authors named "David H Hackos"

Claim this Profile
D
Differential roles of Na1.2 and Na1.6 in neocortical pyramidal cell excitability.
Joshua D Garcia, Chenyu Wang, Ryan P D Alexander, Emmie Banks, Timothy Fenton, David H Hackos

Elife· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Differential roles of Na 1.2 and Na 1.6 in neocortical pyramidal cell excitability.
Joshua D Garcia, Chenyu Wang, Ryan P D Alexander, Emmie Banks, Timothy Fenton, David H Hackos

bioRxiv· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of Na1.7.
Shaoyi Sun, Sultan Chowdhury, Ivan Hemeon, Abid Hasan, Michael S Wilson, David H Hackos

Bioorg Med Chem Lett· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Toxigenic Clostridium perfringens Isolated from At-Risk Paediatric Inflammatory Bowel Disease Patients.
James Kuo, Jasmina Uzunovic, Amanda Jacobson, Michelle Dourado, Sarah Gierke, David H Hackos

J Crohns Colitis· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
Flora I Hinz, Carmela Louise M Villegas, Jasmine T Roberts, Heming Yao, Shreya Gaddam, David H Hackos

J Neurosci· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of TRPA1 Antagonist : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Jack A Terrett, Justin Q Ly, Paula Katavolos, Catrin Hasselgren, Steven Laing, David H Hackos

J Med Chem· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Challenges of profiling motor neuron transcriptomes from human spinal cord.
Olivia Gautier, Jacob A Blum, James Maksymetz, Derek Chen, Christoph Schweingruber, David H Hackos

Neuron· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids.
Lunbin Deng, Michelle Dourado, Rebecca M Reese, Kevin Huang, Shannon D Shields, David H Hackos

Neuron· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
W
Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, David H Hackos

Genome Med· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cryo-EM reveals an unprecedented binding site for Na1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, David H Hackos

Elife· March 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function.
Min Jung, Michelle Dourado, James Maksymetz, Amanda Jacobson, Benjamin I Laufer, David H Hackos

Nat Commun· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Alessia Balestrini, Victory Joseph, Michelle Dourado, Rebecca M Reese, Shannon D Shields, David H Hackos

J Exp Med· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Jack A Terrett, Huifen Chen, Daniel G Shore, Elisia Villemure, Robin Larouche-Gauthier, David H Hackos

J Med Chem· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Acyl-sulfonamide Na1.7 Inhibitors GDC-0276 and GDC-0310.
Brian S Safina, Steven J McKerrall, Shaoyi Sun, Chien-An Chen, Sultan Chowdhury, David H Hackos

J Med Chem· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Jesse E Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, David H Hackos

Cell Rep· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma.
Rebecca M Reese, Michelle Dourado, Keith Anderson, Søren Warming, Kimberly L Stark, David H Hackos

Sci Rep· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism.
Tania Chernov-Rogan, Eleonora Gianti, Chang Liu, Elisia Villemure, Andrew P Cridland, David H Hackos

Proc Natl Acad Sci U S A· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel Na1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers.
Michael E Rothenberg, Michael Tagen, Jae H Chang, Janel Boyce-Rustay, Michel Friesenhahn, David H Hackos

Clin Drug Investig· September 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel Na1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers.
Michael E Rothenberg, Michael Tagen, Jae H Chang, Janel Boyce-Rustay, Michel Friesenhahn, David H Hackos

Clin Drug Investig· September 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na1.7 Inhibitors for the Treatment of Chronic Pain.
Steven J McKerrall, Teresa Nguyen, Kwong Wah Lai, Philippe Bergeron, Lunbin Deng, David H Hackos

J Med Chem· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural basis of α-scorpion toxin action on Na channels.
Thomas Clairfeuille, Alexander Cloake, Daniel T Infield, José P Llongueras, Christopher P Arthur, David H Hackos

Science· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Hui Xu, Tianbo Li, Alexis Rohou, Christopher P Arthur, Foteini Tzakoniati, David H Hackos

Cell· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Hui Xu, Tianbo Li, Alexis Rohou, Christopher P Arthur, Foteini Tzakoniati, David H Hackos

Cell· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na) 1.7 with Potent Analgesic Activity.
Shaoyi Sun, Qi Jia, Alla Y Zenova, Michael S Wilson, Sultan Chowdhury, David H Hackos

J Med Chem· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.
Shannon D Shields, Lunbin Deng, Rebecca M Reese, Michelle Dourado, Janet Tao, David H Hackos

J Neurosci· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis