Publications by authors named "Shannon D Shields"

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Discovery of TRPA1 Antagonist : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Jack A Terrett, Justin Q Ly, Paula Katavolos, Catrin Hasselgren, Steven Laing, Shannon D Shields

J Med Chem· March 2024

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Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids.
Lunbin Deng, Michelle Dourado, Rebecca M Reese, Kevin Huang, Shannon D Shields

Neuron· September 2023

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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
Elisia Villemure, Jack A Terrett, Robin Larouche-Gauthier, Martin Déry, Huifen Chen, Shannon D Shields

ACS Med Chem Lett· August 2021

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A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Alessia Balestrini, Victory Joseph, Michelle Dourado, Rebecca M Reese, Shannon D Shields

J Exp Med· April 2021

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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Jack A Terrett, Huifen Chen, Daniel G Shore, Elisia Villemure, Robin Larouche-Gauthier, Shannon D Shields

J Med Chem· April 2021

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Discovery of Acyl-sulfonamide Na1.7 Inhibitors GDC-0276 and GDC-0310.
Brian S Safina, Steven J McKerrall, Shaoyi Sun, Chien-An Chen, Sultan Chowdhury, Shannon D Shields

J Med Chem· March 2021

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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Chang Liu, Rebecca Reese, Simon Vu, Lionel Rougé, Shannon D Shields

Neuron· January 2021

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Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma.
Rebecca M Reese, Michelle Dourado, Keith Anderson, Søren Warming, Kimberly L Stark, Shannon D Shields

Sci Rep· January 2020

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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na1.7 Inhibitors for the Treatment of Chronic Pain.
Steven J McKerrall, Teresa Nguyen, Kwong Wah Lai, Philippe Bergeron, Lunbin Deng, Shannon D Shields

J Med Chem· April 2019

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Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.
Shannon D Shields, Lunbin Deng, Rebecca M Reese, Michelle Dourado, Janet Tao

J Neurosci· November 2018

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Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Huifen Chen, Matthew Volgraf, Steven Do, Aleksandr Kolesnikov, Daniel G Shore, Shannon D Shields

J Med Chem· April 2018

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BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Martin Weber, Tiffany Wu, William J Meilandt, Sara L Dominguez, Hilda O Solanoy, Shannon D Shields

Sci Rep· March 2017

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Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis.
Shannon D Shields, Richard P Butt, Sulayman D Dib-Hajj, Stephen G Waxman

PLoS One· January 2016

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Conditional deletion of HCN2 from primary afferents uncovers the heterogeneity of inflammatory hypersensitivity.
Shannon D Shields

Pain· June 2014

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Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury.
Carlos González-Fernández, Carmen María Fernández-Martos, Shannon D Shields, Ernest Arenas, Francisco Javier Rodríguez

J Neurotrauma· March 2014

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Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system.
Shannon D Shields, Hye-Sook Ahn, Yang Yang, Chongyang Han, Rebecca P Seal

Pain· October 2012

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Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.
Shannon D Shields, Xiaoyang Cheng, Nurcan Uçeyler, Claudia Sommer, Sulayman D Dib-Hajj

J Neurosci· August 2012

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A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.
Shannon D Shields, Xiaoyang Cheng, Andreas Gasser, Carl Y Saab, Lynda Tyrrell

Ann Neurol· February 2012

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Cerebellar dysfunction in multiple sclerosis: in the blink of an eye.
Shannon D Shields, Stephen G Waxman

Mult Scler· October 2011

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Intracellular pH in primary somatosensory neurons.
Shannon D Shields

Neurosci Lett· August 2011

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Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors.
Shannon D Shields, Daniel J Cavanaugh, Hyosang Lee, David J Anderson, Allan I Basbaum

Pain· November 2010

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Olfactory ensheathing glia express aquaporin 1.
Shannon D Shields, Katherine D Moore, Patricia E Phelps, Allan I Basbaum

J Comp Neurol· November 2010

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Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.
Daniel J Cavanaugh, Hyosang Lee, Liching Lo, Shannon D Shields, Mark J Zylka

Proc Natl Acad Sci U S A· June 2009

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Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons.
Shannon D Shields, Javier Mazario, Kate Skinner, Allan I Basbaum

Pain· September 2007

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Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis.
Shannon D Shields, William A Eckert, Allan I Basbaum

J Pain· October 2003

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