Publications by authors named "Kevin W Hunt"

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Effects of a ketamine metabolite on synaptic NMDAR function.
Kanzo Suzuki, Elena Nosyreva, Kevin W Hunt, Ege T Kavalali, Lisa M Monteggia

Nature· June 2017

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Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp.
Ryan Takahashi, Shuguang Ma, Qin Yue, Heasook Kim-Kang, Yijun Yi, Kevin W Hunt

Eur J Drug Metab Pharmacokinet· June 2015

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8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.
Allen A Thomas, Kevin W Hunt, Brad Newhouse, Ryan J Watts, Xingrong Liu

J Med Chem· December 2014

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Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Matthew Volgraf, Lina Chan, Malcolm P Huestis, Hans E Purkey, Michael Burkard, Kevin W Hunt

Bioorg Med Chem Lett· June 2014

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Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction.
Young G Shin, Lee Hamm, Stanley Murakami, Kenji Buirst, Michael H Buonarati, Kevin W Hunt

Arch Pharm Res· May 2014

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Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.
Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Kevin W Hunt

Drug Metab Dispos· May 2014

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Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, Ryan J Watts, Xingrong Liu

J Med Chem· February 2014

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Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J Watts, Melis Coraggio, Kevin W Hunt

Drug Metab Dispos· July 2013

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Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.
Kevin W Hunt, Adam W Cook, Ryan J Watts, Christopher T Clark, Guy Vigers

J Med Chem· April 2013

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Selective synthesis of 1-functionalized-alkyl-1H-indazoles.
Kevin W Hunt, David A Moreno, Nicole Suiter, Christopher T Clark, Ganghyeok Kim

Org Lett· November 2009

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Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry.
K C Nicolaou, Markus Follmann, A J Roecker, Kevin W Hunt

Angew Chem Int Ed Engl· June 2002

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Oxabicyclo[3.2.1]octenes in organic synthesis: direct ring opening of oxabicyclo[3.2.1] ring systems with diisobutylaluminum hydride and a silyl ketene acetal--synthesis of the chiral C(19)-C(26) and C(27)-C(32) fragments of Scytophycin C.
Kevin W Hunt, Paul A Grieco

Org Lett· January 2002

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