Publications by authors named "Steven Kumpf"

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Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury.
Changhua Ji, Steven Kumpf, Jessie Qian, Joel D Federspiel, Mark Sheehan

Cancer Immunol Immunother· May 2025

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In vitro NIH3T3 mouse embryonic fibroblast cell model does not predict AAV2 or AAVdj-mediated cell transformation.
Luping Qiu, Steven W Kumpf, Elias M Oziolor, Mark Sheehan, James E Finley

Toxicol Appl Pharmacol· February 2025

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Comparison and cross-validation of long-read and short-read target-enrichment sequencing methods to assess AAV vector integration into host genome.
Mark Sheehan, Steven W Kumpf, Jessie Qian, David M Rubitski, Elias Oziolor

Mol Ther Methods Clin Dev· December 2024

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A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6 T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation.
Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Steven W Kumpf

J Pharmacol Exp Ther· July 2023

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Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.
Paul Yenerall, Tae Sung, Kiran Palyada, Jessie Qian, Seda Arat, Steven W Kumpf

Toxicol Sci· June 2023

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Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs.
Elias M Oziolor, Steven W Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan

Mol Ther Methods Clin Dev· June 2023

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Effects of donor source on transcriptomic profiles of human kidney tissue.
Seda Arat, Renee Huynh, Steven Kumpf, Jessie Qian, Ahmed Shoieb

FASEB J· March 2023

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Biodistribution and Tolerability of AAV-PHP.B-CBh- in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles.
Xavier Palazzi, Ingrid D Pardo, Madhu P Sirivelu, Leah Newman, Steven W Kumpf

Hum Gene Ther· February 2022

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Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays.
Natasha R Catlin, Christopher J Bowman, Sarah N Campion, Scott D Davenport, William P Esler, Steven W Kumpf

Toxicol Sci· January 2021

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Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors.
Changhua Ji, Marc D Roy, Jonathan Golas, Allison Vitsky, Sripad Ram, Steven W Kumpf

Clin Cancer Res· August 2019

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Use of Rat Primary Mesenteric Cells for the Prediction of PDE4 Inhibitor Drug-Induced Vascular Injury.
Mark M Gosink, Robert E Chapin, Dean Wilkie, Scott Davenport, Steven W Kumpf

Toxicol Sci· September 2017

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Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells.
Robert E Chapin, Douglas J Ball, Zaher A Radi, Steven W Kumpf, Petra H Koza-Taylor

Toxicol Sci· January 2017

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Lost in translation: The search for an in vitro screen for spermatogenic toxicity.
Robert E Chapin, Timothy Winton, William Nowland, Nichole Danis, Steven Kumpf

Birth Defects Res B Dev Reprod Toxicol· December 2016

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The genomic sequence of lymphocryptovirus from cynomolgus macaque.
Cris Kamperschroer, Mark M Gosink, Steven W Kumpf, Lynn M O'Donnell, Karrie R Tartaro

Virology· January 2016

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Age-related testicular toxicity of mGluR5 negative allosteric modulators appears to be unrelated to testis drug transporter maturity.
Sarah N Campion, John M Marcek, Steven W Kumpf, Robert E Chapin, Christopher Houle

Reprod Toxicol· April 2015

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Quantitative PCR assays reveal high prevalence of lymphocryptovirus as well as lytic phase gene expression in peripheral blood cells of cynomolgus macaques.
Cris Kamperschroer, Karrie Tartaro, Steven W Kumpf

J Virol Methods· October 2014

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Primary cell cultures for understanding rat epididymal inflammation.
Robert E Chapin, Timothy R Winton, William S Nowland, Steven W Kumpf, Scott Davenport

Birth Defects Res B Dev Reprod Toxicol· August 2014

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Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design.
Jason Thomson, Kjell Johnson, Robert Chapin, Donald Stedman, Steven Kumpf

Birth Defects Res B Dev Reprod Toxicol· April 2011

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Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry.
Jennifer A Paquette, Steven W Kumpf, Randal D Streck, Jason J Thomson, Robert E Chapin

Birth Defects Res B Dev Reprod Toxicol· April 2008

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Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006.
Robert Chapin, Donald Stedman, Jennifer Paquette, Randal Streck, Steven Kumpf

Toxicol In Vitro· December 2007

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Validation of rat reference genes for improved quantitative gene expression analysis using low density arrays.
Jenny Hong Cai, Shibing Deng, Steven W Kumpf, Patricia A Lee, Panayiotis Zagouras

Biotechniques· April 2007

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Rat embryos express transcripts for cyclooxygenase-1 and carbonic anhydrase-4, but not for cyclooxygenase-2, during organogenesis.
Randal D Streck, Steven W Kumpf, Terence R S Ozolins, Donald B Stedman

Birth Defects Res B Dev Reprod Toxicol· February 2003

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