Publications by authors named "Steven M Chan"

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Real-world experience with CPX-351 for secondary acute myeloid leukaemia: Comparison with FLAG-IDA in a propensity score matching analysis.
Maria Agustina Perusini, Ana Flavia Patiño, Claire Andrews, Sarit E Assouline, Joseph M Brandwein, Steven M Chan

Br J Haematol· December 2025

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Enasidenib plus venetoclax in patients with IDH2-mutated relapsed or refractory acute myeloid leukaemia or myelodysplastic syndrome (ENAVEN-AML): a multicentre, single-arm, phase 1b/2 trial.
Guillaume Richard-Carpentier, Gopila Gupta, Charina Koraksic, Severine Cathelin, Lisa Wang, Steven M Chan

Lancet Haematol· November 2025

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Response to Immune Checkpoint Blockade is Enhanced in the Presence of Hematopoietic TET2 Inactivation.
Vincent Rondeau, Suraj Bansal, Marco M Buttigieg, Andy G X Zeng, Darryl Y Chan, Michelle Chan-Seng-Yue, Steven M Chan

Cancer Res· November 2025

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Novel and emerging therapeutic strategies for clonal haematopoiesis.
Mohsen Hosseini, Steven M Chan

Haematologica· November 2025

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Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia.
Tracy Murphy, Boyang Zhang, Tong Zhang, Ian King, Jose-Mario Capo-Chichi, Chantal Rockwell, Steven M Chan

Haematologica· July 2025

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Metformin reduces the competitive advantage of Dnmt3a HSPCs.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Steven M Chan

Nature· June 2025

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Mutant cooperates with or to drive distinct myeloid diseases and molecular outcomes.
Takashi Sakamoto, Julie Leca, Xin Zhang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Steven M Chan, Chantal Tobin

Proc Natl Acad Sci U S A· May 2025

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Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
Kira A Young, Mohsen Hosseini, Jayna J Mistry, Claudia Morganti, Taylor S Mills, Steven M Chan

Nat Commun· April 2025

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TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling.
Yitong Yang, Severine Cathelin, Alex C H Liu, Amit Subedi, Abdula Maher, Steven M Chan

Nat Commun· March 2025

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Outcomes and adverse events in older acute lymphoblastic Leukemia patients treated with a pediatric-inspired protocol with Pegylated or native Asparaginase.
Maria Agustina Perusini, Claire Andrews, Eshetu G Atenafu, Vikas Gupta, Dawn Maze, Steven M Chan

Hematology· December 2024

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ADTGP: correcting single-cell antibody sequencing data using Gaussian process regression.
Alex C H Liu, Steven M Chan

Bioinformatics· November 2024

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Genomic profiles and outcomes in de novo versus therapy-related core binding factor AML.
May Chiu, Aaron D Schimmer, Andre C Schuh, Aniket Bankar, Guillaume Richard-Carpentier, Steven M Chan

Blood Cancer J· October 2024

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Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol.
Maria Agustina Perusini, Claire Andrews, Atenafu G Eshetu, Vikas Gupta, Dawn Maze, Steven M Chan

Leukemia· April 2024

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Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms.
Tracy Murphy, Jacqueline M Mason, Brian Leber, Mark R Bray, Steven M Chan

Leukemia· March 2024

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Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia.
Tracy Murphy, Jinfeng Zou, Andrea Arruda, Ting Ting Wang, Zhen Zhao, Steven M Chan

Haematologica· February 2024

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Metformin reduces the clonal fitness of hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Steven M Chan

Res Sq· February 2024

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Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole.
Victoria G Hall, Kenny Tang, Deepali Kumar, Coleman Rotstein, Signy Chow, Steven M Chan

Open Forum Infect Dis· March 2023

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Safety of re-challenging adults with acute lymphoblastic leukemia with PEG-asparaginase-induced severe hypertriglyceridemia when treated with a pediatric-inspired regimen.
Ibrahim Al Nabhani, Claire Andrews, Jad Sibai, Eshetu Atenafu, Taylor Young, Steven M Chan

EJHaem· February 2023

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Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness.
Alex C H Liu, Severine Cathelin, Yitong Yang, David L Dai, Dhanoop Manikoth Ayyathan, Steven M Chan

Cancer Res· December 2022

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Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Severine Cathelin, David Sharon, Amit Subedi, Dan Cojocari, Darren C Phillips, Steven M Chan

Leukemia· March 2022

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Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target.
Robert J Vanner, Stephanie M Dobson, Olga I Gan, Jessica McLeod, Erwin M Schoof, Michelle Chan-Seng-Yue, Steven M Chan

Blood Cancer Discov· January 2022

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RUNX1 mutations correlate with response to venetoclax combination therapies in relapsed/refractory acute myeloid leukemia.
Signy Chow, Kenny Tang, Mahmood Al-Abri, Victoria Hall, Rosemarie Tremblay-Lemay, Steven M Chan

Leuk Res· December 2021

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Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis.
Amit Subedi, Qiang Liu, Dhanoop M Ayyathan, David Sharon, Severine Cathelin, Changjiang Xu, Steven M Chan

Cell Stem Cell· October 2021

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Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing.
Sagi Abelson, Andy G X Zeng, Ido Nofech-Mozes, Ting Ting Wang, Stanley W K Ng, Steven M Chan

Sci Adv· December 2020

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Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen.
Ruiqi Chen, Xing Liu, Arjun D Law, Solaf Kanfar, Dawn Maze, Steven M Chan

Curr Oncol· December 2020

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