Publications by authors named "Steven M Offer"

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Lethal 5-Fluorouracil Toxicity in a Carrier of c.704G>A (p.R235Q).
Brianna M Bembenek, Aneena Joshy, Steven M Offer

JCO Precis Oncol· November 2024

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Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD.
Jonathan E Knikman, Qinglian Zhai, Carin A T C Lunenburg, Linda M Henricks, Stefan Böhringer, Steven M Offer

Genome Med· August 2024

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Approach for Phased Sequence-Based Genotyping of the Critical Pharmacogene Dihydropyrimidine Dehydrogenase ().
Alisa Ambrodji, Angélique Sadlon, Ursula Amstutz, Dennis Hoch, Martin D Berger, Steven M Offer

Int J Mol Sci· July 2024

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Response to "DPYD genotyping panels: Impact of population diversity".
Andrea Gaedigk, Amy J Turner, Cyrine E Haidar, Philip E Empey, Steven M Offer

Clin Transl Sci· April 2024

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Germline variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ().
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Steven M Offer

Elife· April 2024

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Germline variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ().
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Steven M Offer

bioRxiv· March 2024

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Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing.
Amy J Turner, Cyrine E Haidar, Wenjian Yang, Erin C Boone, Steven M Offer

Clin Transl Sci· January 2024

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Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation.
Qing Wen, Jiaqi Zhou, Congcong Tian, Xinran Li, Guibing Song, Steven M Offer

Nat Genet· September 2023

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BEDwARS: a robust Bayesian approach to bulk gene expression deconvolution with noisy reference signatures.
Saba Ghaffari, Kelly J Bouchonville, Ehsan Saleh, Remington E Schmidt, Steven M Offer

Genome Biol· August 2023

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Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy.
Robert B Diasio, Steven M Offer

Cancers (Basel)· June 2022

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Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling.
Xinran Li, Jiaqi Zhou, Wenjuan Zhao, Qing Wen, Weijie Wang, Steven M Offer

Genomics Proteomics Bioinformatics· February 2022

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Pharmacogenomic-Guided Therapy in Colorectal Cancer.
Robert B Diasio, Federico Innocenti, Steven M Offer

Clin Pharmacol Ther· September 2021

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Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity.
Seid Hamzic, Dominic Schärer, Steven M Offer, Didier Meulendijks, Christos Nakas

Br J Clin Pharmacol· August 2021

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Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance.
Zhiquan Wang, Rentian Wu, Qian Nie, Kelly J Bouchonville, Robert B Diasio, Steven M Offer

J Natl Cancer Cent· March 2021

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An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes.
Saba Ghaffari, Casey Hanson, Remington E Schmidt, Kelly J Bouchonville, Steven M Offer

Genome Biol· January 2021

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A Novel Nomenclature for Repeat Motifs in the Thymidylate Synthase Enhancer Region and Its Relevance for Pharmacogenetic Studies.
Dominic Schaerer, Tanja K Froehlich, Seid Hamzic, Steven M Offer, Robert B Diasio

J Pers Med· October 2020

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Severe Capecitabine Toxicity Associated With a Rare Variant Identified Through Whole-Genome Sequencing.
Reynold C Ly, Remington E Schmidt, Patrick J Kiel, Victoria M Pratt, Bryan P Schneider, Steven M Offer

JCO Precis Oncol· June 2020

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Dose modification for safe treatment of a compound complex heterozygous variant carrier with 5-fluorouracil.
Shikshya Shrestha, Erin E Tapper, Colbren Scout Trogstad-Isaacson, Timothy J Hobday, Steven M Offer

JCO Precis Oncol· October 2018

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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.
Shikshya Shrestha, Cheng Zhang, Calvin R Jerde, Qian Nie, Hu Li, Steven M Offer

Clin Pharmacol Ther· October 2018

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.
Ursula Amstutz, Linda M Henricks, Steven M Offer, Julia Barbarino, Jan H M Schellens

Clin Pharmacol Ther· February 2018

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Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter.
Rentian Wu, Qian Nie, Erin E Tapper, Calvin R Jerde, Garrett S Dunlap, Steven M Offer

Cancer Res· November 2016

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Biomarkers of Fluorouracil Toxicity: Insight From the PETACC-8 Trial.
Steven M Offer, Robert B Diasio

JAMA Oncol· May 2016

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A phosphotyrosine switch regulates organic cation transporters.
Jason A Sprowl, Su Sien Ong, Alice A Gibson, Shuiying Hu, Guoqing Du, Steven M Offer

Nat Commun· March 2016

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Is It Finally Time for a Personalized Medicine Approach for Fluorouracil-Based Therapies?
Steven M Offer, Robert B Diasio

J Clin Oncol· January 2016

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Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy.
Ursula Amstutz, Steven M Offer, Johanna Sistonen, Markus Joerger, Robert B Diasio

Clin Cancer Res· May 2015

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