Publications by authors named "Steven Middleton"

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Understanding sensory abnormalities in fibromyalgia through autoantibodies.
Andreas C Themistocleous, Steven J Middleton, John M Dawes

Brain· November 2025

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SLC45A4 is a pain gene encoding a neuronal polyamine transporter.
Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng

Nature· October 2025

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Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Chinnakkaruppan Adaikkan, Jun Wang, Karim Abdelaal, Steven J Middleton, P Lorenzo Bozzelli

Neuron· October 2025

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Specific overexpression of contactin-associated protein-like 2 and its effects on pain-related behaviour in mice.
Mandy Tseng, Steven J Middleton, Adham Farah, Sarosh R Irani, John M Dawes

Pain Rep· August 2025

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In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors.
Evangelia Semizoglou, Laure Lo Re, Steven J Middleton, Jimena Perez-Sanchez, Tommaso Tufarelli

J Physiol· February 2025

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Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.
Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng

bioRxiv· September 2024

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Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.
Chinnakkaruppan Adaikkan, Justin Joseph, Georgios Foustoukos, Jun Wang, Denis Polygalov, Steven J Middleton

Nat Commun· March 2024

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GluCl.Cre ON enables selective inhibition of molecularly defined pain circuits.
Steven J Middleton, Huimin Hu, Jimena Perez-Sanchez, Sana Zuberi, Joseph McGrath Williams

Pain· December 2023

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Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons.
Hyoung Woo Kim, Sang Wook Shim, Anna Mae Zhao, Dahee Roh, Hye Min Han, Steven J Middleton

Pain· October 2023

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A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.
Jimena Perez-Sanchez, Steven J Middleton, Luke A Pattison, Helen Hilton, Mosab Ali Awadelkareem

Sci Transl Med· October 2023

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The structure of sensory afferent compartments in health and disease.
Steven J Middleton, Jimena Perez-Sanchez, John M Dawes

J Anat· November 2022

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Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.
Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann

Brain· October 2022

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Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Chinnakkaruppan Adaikkan, Jun Wang, Karim Abdelaal, Steven J Middleton, P Lorenzo Bozzelli

Neuron· October 2022

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Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.
Teodora Trendafilova, Kaustubh Adhikari, Annina B Schmid, Ryan Patel, Erika Polgár, Steven J Middleton

Neuron· August 2022

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Lateralization of CA1 assemblies in the absence of CA3 input.
Hefei Guan, Steven J Middleton, Takafumi Inoue, Thomas J McHugh

Nat Commun· October 2021

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Studying human nociceptors: from fundamentals to clinic.
Steven J Middleton, Allison M Barry, Maddalena Comini, Yan Li, Pradipta R Ray

Brain· June 2021

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A hypothalamic novelty signal modulates hippocampal memory.
Shuo Chen, Linmeng He, Arthur J Y Huang, Roman Boehringer, Vincent Robert, Steven J Middleton

Nature· October 2020

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CA2: A Highly Connected Intrahippocampal Relay.
Steven J Middleton, Thomas J McHugh

Annu Rev Neurosci· July 2020

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Memory: Sequences Take Time.
Steven J Middleton, Thomas J McHugh

Curr Biol· March 2019

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Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene.
Steven J Middleton, Emily M Kneller, Shuo Chen, Ikuo Ogiwara, Mauricio Montal

Nat Neurosci· July 2018

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Chemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma.
Frank Herting, Thomas Friess, Pablo Umaña, Steven Middleton, Christian Klein

Leuk Lymphoma· June 2018

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Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
John M Dawes, Greg A Weir, Steven J Middleton, Ryan Patel, Kim I Chisholm

Neuron· February 2018

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Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov

Brain· October 2017

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Congenital deafness is associated with specific somatosensory deficits in adolescents.
Rabih Moshourab, Valérie Bégay, Christiane Wetzel, Jan Walcher, Steven Middleton

Sci Rep· June 2017

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